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Azelaic Acid

Description

Azelaic acid has antimicrobial, anti-inflammatory, and anti-keratinizing effect

s. It works by inhibiting protein synthesis in skin bacteria (C. acnes), reducing the body's inflammatory response by scavenging free radicals, and normalizing the skin's cell turnover process to prevent pore blockage. It is primarily used as a topical treatment. Its main therapeutic uses are treating mild-to-moderate Acne Vulgaris and the redness, bumps, and pustules associated with Rosacea. It is also used as against hyperpigmentation (like melasma) because it inhibits the enzyme tyrosinase, which is key to melanin production. Azelaic acid is commonly available in topical creams, gels, and foam formulations, typically in concentrations of 15% or 20%.

uses

Uses

Azelaic acid is used in the treatment of mild to moderate acne.
contraindications

Contraindications

When should one not use Azelaic Acid

If you are allergic to Azelaic acid.
sideEffects

Side effects

Common side effects of this drug are:

  • Burning or pricking sensation.
  • Pain at the applied area.
  • Urge to scratch or dryness.
  • Swelling at the site of application.
precautionsAndWarnings

Precautions and Warnings

pregnancy

Pregnancy

Q:
Can I use Azelaic acid during pregnancy?
A:
This medicine is to be applied on topical surfaces and the quantities which might get absorbed from the skin is too little and there are rare chances of absorption. Still, this medicine should be used with caution and only under medical supervision.
breastfeeding

Breast Feeding

Q:
Can I use Azelaic acid while breastfeeding?
A:
There is limited information on the use of this medicine during breastfeeding. Hence, it is recommended to be cautious while breastfeeding. It should not be applied to the breast of breastfeeding mothers or on large areas of skin or for a prolonged period of time.
driving

Driving

Q:
Can I drive if I have applied Azelaic acid?
A:
It is a topical preparation and may not affect the driving ability or ability to handle machinery.
alcohol

Alcohol

Q:
Can I consume alcohol with Azelaic acid?
A:
Interaction of this medicine with alcohol is very unlikely, as it is applied on the skin, but it is better to consult a doctor if you consume alcohol in excess.
otherGeneralWarnings

Other General Warnings

Talk to your doctor if
  • You experience excessive irritation and burning of the skin after the application of Azelaic acid.
  • In case your eyes come in contact with this medicine, rinse your eyes with clean water immediately.
  • Avoid contact with the eyes, mouth and other mucous membranes.
  • Hands should be washed after each application of Azelaic acid.
modeOfAction

Mode of Action

How Does It Work?

Azelaic acid reduces the redness and swelling of the skin and also kills the bacteria responsible for causing acne.
interactions

Interactions

Interactions with other medicines

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines. Azelaic acid may affect the way other medicines work.
dosage

Dosage

Overdose

As Azelaic acid is mainly meant for external application, cases of an overdose are unlikely. However, if you accidentally ingest it, contact your doctor immediately or visit the nearest hospital. If y...
Read more

Missed a Dose

If you have missed applying Azelaic acid, apply it as soon as possible. Do not over apply this medicine to compensate for the missed dose.

Content Details

WRITTEN BY
doctor

Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery), WHO FIDES member

REVIEWED BY
doctor

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

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Q: For how long do I need to apply Azelaic acid?

A: The duration of this medicine will depend on the response to treatment. You need to follow the doctor's instructions and do not stop using this medicine on your own. If you stop using it too soon, your acne may return or get worse.

Q: What precautions do I need to take before applying Azelaic acid?

  • Avoid using this medicine for a longer duration than your doctor suggested.
  • Do not apply it to windburned, sunburned skin or on open wounds.
  • Do not use it in or around the eyes, lips or inside of the nose.
  • Rub it gently around the area applied.
  • Wash your hands after applying to remove any medicine that may remain on them.

Q: How does Azelaic Acid work on my skin?

  • It works in three ways: 1. It kills bacteria (C. acnes) that cause acne. 2. It reduces inflammation and redness (anti-inflammatory effect). 3. It helps your skin cells turn over normally, which keeps ...
    Read more

Q: What are the most common side effects of Azelaic Acid?

  • The most common side effects happen when you first start using it, and include mild burning, stinging, tingling, itching, or redness at the site of application. These usually lessen as your skin gets ...
    Read more
Last Updated on: 25 Nov 2025 | 06:04 PM (IST)
Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here  for detailed T&C.
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