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Aceclofenac+Paracetamol / Acetaminophen

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Molecule Description

Aceclofenac plus paracetamol is a combined medication used to relieve pain, swelling, and inflammation in adults. Both Aceclofenac and paracetamol work by blocking certain chemicals that cause these symptoms. They are available in tablet, capsule, syrup, and suspension forms. Most patients can safely use Aceclofenac plus paracetamol, but some may experience common side effects like nausea, vomiting, stomach pain, heartburn, and diarrhea, along with less common and rare side effects. If you are taking this medication for long-term pain, continue as directed by your doctor. It can be stopped if used for short-term relief. Long-term use of Aceclofenac plus paracetamol can damage the kidneys, as they normally produce prostaglandin chemicals that protect them from harm. Painkillers lower prostaglandin levels, which can lead to kidney damage over time. Use of painkillers is not recommended for patients with pre-existing kidney disease.

Uses

For relieving pain, inflammation and swelling in various forms of arthritis. It is also useful in gynaecological pain, dental pain, low backache, pain and swelling in the ear, nose and throat.

Contraindications

When should one not use Aceclofenac+Paracetamol / Acetaminophen

If you are allergic to paracetamol and aceclofenac. If you have a history of ulcer or bleeding in the stomach or any part of your digestive tract. If you have experienced an allergic reaction due to the use of other pain-relieving medicines such as aspirin, ibuprofen. If you have any heart-related problems, high blood pressure, kidney or liver-related problem. If you are pregnant, especially in the last trimester of pregnancy.

Side effects

Common side effects of this drug are:

  • Dizziness
  • Drowsiness
  • Dyspepsia
  • Abdominal pain
  • Nausea
  • Diarrhoea

Precautions and Warnings

Pregnancy

Pregnancy

Aceclofenac+paracetamol should not be used during pregnancy especially in third trimester.

Breast Feeding

Breast Feeding

Aceclofenac+paracetamol should not be used by a lactating woman unless considered essential by the treating doctor.

Driving

Driving

Long term treatment with this combination may cause dizziness. Driving or operating machinery is to be avoided.

Alcohol

Alcohol

Although there is no known interaction with alcohol and aceclofenac+paracetamol, it is essential to consult your physician if you have a habit of regular drinking. Consuming alcohol while taking pain killers is known to increase the risk of bleeding, ulcer and perforation in stomach and intestine (upper gastrointestinal tract).

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have a kidney or liver problem or blood clotting disorder.
  • You have a bleeding problem in the stomach, ulcers in the intestine (perforation) or Crohn's disease.
  • You have asthma, as this medicine can worsen the symptoms of asthma.
  • You have an autoimmune disease called systemic lupus erythematosus.
  • You are an alcoholic, as concomitant use of this medicine can affect the liver.
  • You experience skin rashes & lesions after taking this combination.
  • You are an elderly patient or taking water pills or have kidney disorders; this medicine can affect the risk of kidney failure. Your doctor may ask you to do renal function tests for the same.

Mode of Action

How Does It Work?

Paracetamol works by interfering with the formation of an inflammatory mediator, prostaglandin. Prostaglandin is responsible for pain and swelling. Aceclofenac acts by inhibiting certain enzymes responsible for the formation of prostaglandin, thus helping in relieving pain and reducing swelling.

Interactions

Interactions with other medicines

  • Some medicines affect the way aceclofenac+paracetamol works or this combination itself reduces the effectiveness of other medicines taken at the same time.
  • Inform the doctor about the medicines, supplements, or herbals you are taking or might take to avoid possible interaction.
  • Especially if you are taking medicines for a heart condition, steroids, blood pressure-lowering medicines, certain antibiotics, immunomodulators, blood thinners, antidiabetics, mifepristone and medicines that contain lithium.
  • Avoid concomitant use of other pain-relieving medicines while taking this combination.

Frequently Asked Questions (FAQs)

Use of pain killers may be associated with risk of conditions related to heart, bledding and ulcer in digestive tract. The risk may be more when this medicine is used for prolonged duration and in people with existing heart condition and with risk factor of getting such condition.

If this combination is taken in more than recommended dose it can affect your liver. The chances of getting liver related problem is more common in people who drink everyday more than 3 alcoholic drinks and are taking other medicines containing paracetamol.

Aceclofenac+Paracetamol is a combination of two medications used to relieve pain and inflammation by reducing the levels of chemical substances in the body that cause these symptoms.

Aceclofenac+Paracetamol is generally safe for most patients. However, it may cause some common side effects like nausea, vomiting, stomach pain, heartburn, diarrhea, as well as uncommon and rare side effects in some individuals.

If you are using Aceclofenac+Paracetamol for a long-term pain condition, it should be continued as advised by your physician. It can be discontinued for short-term pain relief.

No, Aceclofenac+Paracetamol should not be taken for stomach pain without consulting a physician as it can increase stomach acid secretion, potentially worsening an underlying condition.

Yes, nausea and vomiting are common side effects of Aceclofenac+Paracetamol. These effects can be mitigated by taking the medication with milk, food, or antacids. If vomiting persists, seek medical advice.

Yes, some patients may experience dizziness while taking Aceclofenac+Paracetamol. It is advisable to rest until the symptoms subside before resuming activity.

Long-term use of Aceclofenac+Paracetamol may lead to kidney damage by reducing the levels of protective chemicals in the body. Patients with kidney disease should avoid prolonged use of painkillers.

Aceclofenac+Paracetamol should be avoided in patients with known allergies to its components, history of stomach ulcers or bleeding, heart failure, high blood pressure, and liver or kidney disease.

Yes, Aceclofenac+Paracetamol can be taken with vitamin B-complex preparations. While Aceclofenac+Paracetamol relieves pain, vitamin B-complex can address underlying vitamin deficiencies.

No, exceeding the recommended dose of Aceclofenac+Paracetamol can increase the risk of side effects and potential kidney damage. Consult a doctor if pain persists.

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