Zoryl Mp 1mg Strip Of 15 Tablets
By INTAS PHARMACEUTICALS LTD
15 Tablet(s) in Strip
₹234.24*
MRP ₹244.00
4% OFF
Inclusive of all taxes
7 days return policyRead More
All the Products are packed and stored Safely
Zoryl Mp 1mg Strip Of 15 Tablets Description
Zoryl Mp 1 mg is a prescription medicine used in the treatment of Type-2 Diabetes, notably in those whose blood sugar levels cannot be managed even after proper diet and exercise. Type 2 diabetes is
a condition in which the body's ability to control and utilise sugar (glucose) as fuel is impaired. It can be due to reduced Insulin production or when body cells do not respond to insulin in the way they should. As a result, your body requires extra insulin to aid glucose absorption into your cells ((insulin resistance). Zoryl Mp 1mg tablet is a combination of three antidiabetic medicines, namely Glimepiride, Metformin, and Pioglitazone. In combination with diet and exercise, this medicine helps to improve blood sugar levels in adults with Type-2 Diabetes. It aids in the proper utilisation of insulin, resulting in decreased blood sugar levels. Side effects are Metallic taste, Hypoglycemia (low blood glucose level), Nausea, Diarrhoea, Vomiting, Taste change, Diarrhoea, Stomach pain, Headache, Edema (swelling), Weight gain, Blurred vision, Bone fracture, Respiratory tract infection. Directions for the use of Zoryl Mp 1 mg tablets should be strictly followed. This medication should be taken at the same time every day. The prescribed dose should be maintained to avoid an incidence of overdose. Sudden stopping of this medication is not advised.
Product Summary
| Offer Price | ₹234.24 |
| You Save | ₹9.76 (4% on MRP) |
| Contains | Pioglitazone(15.0 Mg) + Metformin Hydrochloride(500.0 Mg) + Glimepiride(1.0 Mg) |
| Uses | Treatment of Type 2 diabetes mellitus |
| Side effects | Taste disturbance, Nausea, Vomiting, Diarrhoea, Abdominal pain, Loss of appetite, upper respiratory tract infection, Anaemia, Visual disturbance, Weight gain, Erectile dysfunction, Bone fracture, Headache, Arthralgia |
| Therapy | ANTI-DIABETIC |
Check more medicines with composition as Pioglitazone(15.0 Mg) + Metformin Hydrochloride(500.0 Mg) + Glimepiride(1.0 Mg)
Uses of Zoryl Mp 1mg Strip Of 15 Tablets
- As per CDSCO, Zoryl Mp 1 mg is used in the treatment of Type 2 diabetes mellitus.
Contraindications of Zoryl Mp 1mg Strip Of 15 Tablets
- Hypersensitivity to Glimepiride, Metformin or Pioglitazone, other sulfonylureas or sulfonamides or to any of the excipients
- Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis)
- Insulin-dependent diabetes
- Cardiac failure or history of cardiac failure
- Diabetic ketoacidosis
- Diabetic coma
- Severe renal or hepatic function disorders
- Decompensated heart failure, respiratory failure, recent myocardial infarction, shock, and other diseases that can cause tissue hypoxia (particularly acute disease or exacerbation of chronic disease)
- Bladder cancer in progress or a history of bladder cancer
- Alcoholism, hepatic insufficiency, acute alcohol intoxication
- Conditions that can lead to renal dysfunction like dehydration, severe infection, shock
- Any evidence of fluid overload
- History of fracture or at high risk for fracture
Side effects of Zoryl Mp 1mg Strip Of 15 Tablets
- Taste disturbance
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Loss of appetite
- upper respiratory tract infection
- Anaemia
- Visual disturbance
- Weight gain
- Erectile dysfunction
- Bone fracture
- Headache
- Arthralgia
Precautions and Warnings of Zoryl Mp 1mg Strip Of 15 Tablets
Pregnancy
Q:
Can I take a Zoryl Mp 1mg tablet during pregnancy?
A:
Zoryl Mp 1mg tablets are unsafe during pregnancy. Studies have shown that it causes a definite risk to the foetus. Foetal growth restriction was reported in animal studies. If you are planning a pregnancy, you should inform your doctor.
Breast Feeding
Q:
Can I take Zoryl Mp 1mg tablets while breastfeeding?
A:
No, individual medicines of Zoryl Mp 1mg tablets are secreted into breast milk. Because there is a risk of hypoglycaemia in nursing infants, breastfeeding is advised against during treatment with Zoryl Mp 1mg tablets.
Driving
Q:
Can I drive if I have taken the Zoryl Mp 1mg tablet?
A:
No. You can experience visual disturbances, and you should be cautious when driving or using heavy machines.
Alcohol
Q:
Can I consume alcohol with the Zoryl Mp 1mg tablet?
A:
No. You should not consume alcohol while on treatment with the Zoryl Mp 1mg tablet. There is an increased risk of lactic acidosis, particularly in case you are fasting or are having malnutrition or hepatic impairment.
Other General Warnings
Talk to your doctor if
- You are allergic to Glimepiride, Metformin, or Pioglitazone, other sulfonylureas or sulfonamides or to any of the excipients of this medicine.
- You have renal failure.
- You have severe liver impairment.
- You have a previous history of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis) with any of the component medicines of Zoryl Mp 1mg tablet.
- You are having heart failure or have a history of cardiac failure.
- You are a patient with bladder cancer.
- You are an alcoholic.
- You have an infection or are under treatment for any ongoing infection.
- You have to undergo any imaging procedure involving the administration of an iodinated contrast agent.
- You have to undergo surgery.
- You are an elderly individual.
- You develop visual impairment after starting this medicine.
- You develop liver or renal failure/impairment after starting this medicine.
- You have made changes in your diet or have increased physical activity. The dose needs to be adjusted based on the blood sugar levels.
Mode of Action of Zoryl Mp 1mg Strip Of 15 Tablets
How Does It Work?
Zoryl Mp 1mg tablet is a combination of three antidiabetic medicines, namely Glimepiride, Metformin, and Pioglitazone.
Glimepiride belongs to the sulfonylurea class of medicine. It acts on the functioning pancreatic beta cells to release insulin and thereby regulate blood sugar levels. In addition to this, it also has extrapancreatic effects like increased sensitivity of peripheral tissues to insulin.
Metformin belongs to a class of medicine called biguanides. It acts by blocking lipids and amino acids from being converted to glucose in the liver. It also activates an enzyme called adenosine monophosphate-activated protein kinase (AMPK), which aids cells in responding to insulin and absorbing glucose from the bloodstream.
Pioglitazone belongs to a class of medicine called thiazolidinediones. It works by increasing insulin sensitivity of liver, muscle, and fat cells and enables cells to remove glucose from blood more effectively and also reduces insulin resistance. Thus, it helps in the proper functioning of insulin produced by the body.
The combination of the three medicines works by three different mechanisms and offers precise control of blood sugar when single or dual therapy is not effective....
Directions for Use of Zoryl Mp 1mg Strip Of 15 Tablets
- Take the Zoryl Mp 1mg tablet in the dose and duration as advised by your doctor.
- Swallow it as a whole with a glass of water.
- Do not chew, crush, or break it.
- It is better to take it at a fixed time to maintain a constant level of medicine in the body and achieve the desired clinical effect.
- Continue taking this medicine as long as your doctor recommends.
- The prescribed dose should be maintained to avoid an incidence of overdose. Sudden stopping of this medication is not advised.
Interactions of Zoryl Mp 1mg Strip Of 15 Tablets
Interactions with other medicines
- Medicines that induce the action of CYP2C9 enzyme (e.g. rifampicin) decrease concentration of individual medicines in Zoryl Mp 1mg tablets reach blood supply, thereby decreasing the efficacy of Zoryl Mp 1mg tablets....
- Medicines that inhibit the action of CYP2C9 enzyme (e.g. fluconazole) increase the blood levels of individual medicines in Zoryl Mp 1mg tablets, thereby increasing the chances of side effects of Zoryl Mp 1mg tablets....
- Lipid reducing medicines like gemfibrozil and fenofibrate increase the blood levels of individual medicines in Zoryl Mp 1mg tablet, thereby increasing the chances of side effects of Zoryl Mp 1mg tablet....
- Calcium channel blocker class of antihypertensive medicine like verapamil reduce the efficacy of Zoryl Mp 1mg tablet.
- Anabolic steroids like nandrolone, oxandrolone, oxymetholone - Potentiation of the blood-glucose-lowering effect.
- ACE inhibitor classes of medicines like Captopril increase chances of hypoglycemia (low blood sugar).
- Antibiotic chloramphenicol - Potentiation of the blood-glucose-lowering effect.
- Anticoagulants like Warfarin - Potentiation of the blood-glucose-lowering effect.
- Medicines used to treat Gout like Allopurinol - Potentiation of the blood-glucose-lowering effect
Interactions with food items
- Food has little effect on the absorption of Zoryl Mp 1mg tablets into the blood.
Storage and disposal of Zoryl Mp 1mg Strip Of 15 Tablets
Do not store Zoryl Mp 1mg tablets above 25°C.
Store in the original package.
Keep it away from the reach and sight of children.
Keep it away from direct sunlight, heat, and moisture.
Discard the expired medicine immediately. Do not use it.
Dispose of the packaging carefully after use.
Do not flush extra or expired pills down the toilet....
Dosage of Zoryl Mp 1mg Strip Of 15 Tablets
Overdose
Symptoms of overdose of Zoryl Mp 1mg tablet are hypoglycemia (low blood sugar levels) and lactic acidosis, which can present with nonspecific symptoms and includes severe nausea, vomiting, diarrhoea, epigastric pain, increased thirst, lost appetite, lethargy, and rapid breathing.
Lactic acidosis is a medical emergency and must be treated in a hospital. The most effective method to remove lactate is haemodialysis....
Missed a Dose
If you have missed a dose of Zoryl Mp 1mg tablet, try to take it as soon as you remember. If you recall the missed dose when it is almost time for the next one, skip the missed one and continue with your regular dosing schedule. Do not take both of them together; this can lead to adverse reactions....
Content Details
WRITTEN BY
Dr. Vijay Y
MBBS, MD in Clinical Pharmacology
REVIEWED BY
Dr. Varsha Parihar
MBBS, MD (Community Medicine)
Frequently Asked Questions (FAQs)
Q: What lab tests need to be performed before or after starting Zoryl Mp 1mg tablet?
A: Liver and renal or kidney functions tests need to be performed before starting Zoryl Mp 1mg tablet. These tests might also be needed to be performed periodically thereafter. The frequency of the test monitoring would be based on clinical judgement by your doctor.
Q: Can Zoryl Mp 1mg tablet cause bone fracture?
A: There are some reports of bone fracture after starting the treatment with Pioglitazone, which is one of the component medicines of Zoryl Mp 1mg tablet. Hence it is advised to maintain proper bone health, especially in females.
Q: Can the use of Zoryl Mp 1mg tablet cause Vitamin B12 deficiency?
A: Zoryl Mp 1mg tablet contains Metformin which can cause vitamin B12 deficiency. It interferes with the absorption of vitamin B12 from the gut during long term usage.
Q: Can Zoryl Mp 1mg tablet cause hypoglycemia?
A: Yes, the use of Zoryl Mp 1mg tablet can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include excessive sweating, hunger, fainting, fatigue, light-headedness, shakiness, nausea or vomiting, mental confusion, anxiety, blurred vision, headache, irritability, pallor, palpitations, pins and needles sensation, sleepiness, slurred speech, and tremor.
Q: Can I stop the Zoryl Mp 1mg tablet on my own?
A: It is suggested that you adhere to the dose and duration of the prescription and not discontinue taking Zoryl Mp 1mg tablet on your own, as doing so may result in recurrent symptoms or worsen the disease. If you have any problems while using Zoryl Mp 1mg tablet, please see your doctor so that you can be offered an alternative medication.
References
View All
- Nasri H, Rafieian-Kopaei M. Metformin: Current knowledge. J Res Med Sci. 2014;19(7):658-664 - [cited 26 Mar 2022]
- 2022. [online] Available at: <https://cdscoonline.gov.in/CDSCO/Drugs> [cited 26 Mar 2022].
- Trerattanavong K, Tadi P. Glimepiride. [Updated 2021 Dec 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-.cited 26 Mar 2022] Available from:
- Alam, F., Islam, M.A., Mohamed, M. et al. Efficacy and Safety of Pioglitazone Monotherapy in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Sci Rep 9, 5389 (2019). cited 26 Mar 2022] Available from
- Imre Pavo, et.al. Effect of Pioglitazone Compared with Metformin on Glycemic Control and Indicators of Insulin Sensitivity in Recently Diagnosed Patients with Type 2 Diabetes, The Journal of Clinical Endocrinology & Metabolism, Volume 88, Issue 4, 1 April 2003, Pages 1637–1645, cited 26 Mar 2022] Available from
Product Details
Brand
ZORYL MP
Country of Origin
India
Expires on or After
27/02/2026
Manufacturer Details
Health Articles
Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
Please add item(s) to proceed
Top-Tests we cover:
Top-Selling Healthcare Products:
Top-Selling Medicines:
Top-Searched Medicines:
