Zerodol MR Tablet
Description
Zerodol MR tablets are used to relieve pain and inflammation caused by conditions such as arthritis, back pain, joint pain, and muscle spasms. This medicine combines two active ingredients: aceclofenac, which helps reduce pain and inflammation, and tizanidine, which relaxes tight or stiff muscles to ease discomfort. Together, they work to improve movement and help you feel more comfortable during daily activities.
Many people find this medication helpful for conditions characterised by both pain and muscle tightness. It is essential to take the tablet exactly as your doctor prescribes, typically with food to minimise stomach upset. Taking it after a meal can also help reduce the risk of side effects, such as nausea or acidity. Do not take more than the recommended dose, even if you feel the pain is severe.
Some people may experience side effects such as dizziness, dry mouth, or stomach discomfort. If you feel nauseous, try eating small, light meals throughout the day. Sucking on sugar-free lozenges or drinking water can help relieve dry mouth. Make sure to stay hydrated and avoid alcohol while taking this medicine, as it may worsen side effects like drowsiness or stomach irritation.
Before starting Zerodol MR, let your doctor know if you are pregnant, trying to conceive, or breastfeeding. You should also inform them if you have any medical conditions, especially related to your liver, kidneys, or heart. Other medicines with the same ingredients include Accetiz, Acewok Tz, Acent Tz, Regdol Tz, and Omniflam. Your doctor will choose the most suitable one based on your condition and medical history.
Product Summary
Offer Price | ₹95.56 |
You Save | ₹35.34 (27% on MRP) |
Contains | Aceclofenac(100.0 Mg)+Tizanidine(2.0 Mg) |
Uses | Muscle and joint pain |
Side effects | Dizziness, nausea, vomiting, stomach pain, indigestion |
Therapy | ANALGESIC |
Uses
Contraindications
- If you are allergic to aceclofenac tizanidine, or any other ingredients of this medicine.
- If you are allergic to other painkillers (or NSAIDs) like Ibuprofen, Aspirin, and Diclofenac.
- If you have a history of stomach ulcers or bleeding, bleeding or perforation (tear) from the gastrointestinal tract.
- If you have any bleeding or blood clotting disorders or blood circulation problems.
- If you have heart problems like stroke, heart attack or heart failure.
- If you have a history of severe allergic reactions upon painkiller consumption, like asthmatic attack, runny nose and skin reactions.
- If you're suffering from any liver or kidney disease.
- If you are taking medications like Fluvoxamine (used to treat psychiatric illness) or ciprofloxacin (antibiotic).
- If you are pregnant or are planning to have a baby.
Side effects
- Dizziness
- Nausea
- Vomiting
- Stomach pain
- Indigestion
- Dry mouth
- Constipation
- Flu
- Weakness
- Tiredness
- Sleepiness
- Urinary tract infection
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You have problems with your heart, kidney, liver function, or any other pre-existing health condition.
- You have stomach or intestine issues like bleeding, inflammatory bowel disease or stomach tumour.
- You have blood circulation problems or bleeding disorders or are taking blood thinners.
- You have a condition known as porphyria lupus or chickenpox.
- You have asthma or breathing issues or are a smoker.
- You have diabetes, high blood pressure, high cholesterol, or fats.
- You recently had major surgery and are recovering from it.
Directions for Use
- Take the Zerodol MR tablet as a whole with a sufficient amount of water, after your meal to avoid stomach discomfort.
- Take it regularly and without fail as directed by your doctor and do not consume it more than that prescribed by your doctor.
Storage and disposal
- Store the Zerodol MR tablet below 25°C in a clean and dry place, protected from moisture, sunlight and heat.
- Keep the medicine away from children and pets.
- Discard any unused or expired medicine properly, do not flush in the toilet or throw it into the drain.
Quick Tips
- Before taking this medicine, inform your doctor about all your medications and medical history.
- Zerodol-MR has Side Effects, including nausea, diarrhoea, indigestion, stomach pain, and dizziness. If these side effects bother you, please inform your doctor.
- Take Zerodol MR tablet with food to avoid stomach upset or nausea.
- Zerodol MR tablet is not a steroid; it contains Aceclofenac and Tizanidine, which belong to the group of medicines called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) and Skeletal Muscle Relaxants, respectively....
- This medicine may potentially impact liver function and cause variations in liver enzyme levels. It is contraindicated for use in children and individuals over 65 years of age.
Dosage
Overdose
Missed a Dose
Mode of Action
How Does It Work?
Interactions
Interactions with other medicines
- Tell your doctor about all the medicines, supplements, or herbals you are taking to avoid any possible interaction.
- Especially if you are taking anti-HIV medicine, heart-related medicines, water pills, antidiabetic medicines, immunosuppressants, blood thinners like warfarin, etc.
- Zerodol MR tablet should not be used concomitantly along with antipsychotic medications like fluvoxamine and antibiotics, as it decreases blood pressure significantly, increases sleepiness and reduces many other functions....
- Concomitant use of painkillers, steroids and antiplatelets like Clopidogrel should be avoided as it can cause stomach and intestine bleeding.
- Using antidiabetics along with this medicine can affect your blood sugar level. Your doctor may ask you to monitor your blood sugar level regularly.
- Antibiotics like Levofloxacin can cause fits if you have a history of fits or seizures if taken along with this medicine.
- Other medicines like Lithium, Ticlopidine, Cimetidine, Morphine or Tizanidine should be used cautiously.
Interactions with food items
Content Details

Dr. Arpit Verma
MBBS, MD, CCEBDM Diabetology

Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: Zerodol MR vs Hifenac MR, are they the same?
Q: Is Zerodol MR tablet a painkiller?
Q: Can I take Zerodol MR tablet along with other painkillers?
Q: Can I take two tablets of Zerodol MR at once?
Q: What is the difference between Zerodol MR and Zerodol SP tablet?
Q: Can a diabetic patient use Zerodol MR?
Q: Can Zerodol MR be combined with paracetamol?
Q: Does Zerodol MR tablet cause drowsiness?
Q: Can the use of Zerodol-MR tablets cause nausea and vomiting?
Q: Can Zerodol-MR be taken on an empty stomach?
Q: How long does it take for Zerodol to work?
Q: What is the composition of Zerodol MR?
Q: Does Zerodol MR cause dry mouth?
Q: Can Zerodol MR be taken for arthritic pain?
References
- Aceclofenac 100 mg film-coated tablet - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [cited 5 August 2022]
- ZANAFLEX Capsules [Internet]. Accessdata.fda.gov. 2022 [cited 5 August 2022]
- CDSCO [Internet]. Cdscoonline.gov.in. 2022 [cited 5 August 2022]
- Tizanidine hydrochloride [Internet]. Silver Spring (MD): U.S. Food and Drug Administration; 2013 May. [cited 2024 Dec 23]
- Aceclofenac [Internet]. Bethesda (MD): U.S. National Library of Medicine; [cited 2024 Dec 23].
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