Spegra Bottle Of 90 Tablets

• If you have had a previous hypersensitivity (allergic) reaction to dolutegravir, emtricitabine, or tenofovir alafenamide.
• If you are currently taking a medicine called dofetilide (used to treat abnormal heart rhythms).
• If you have severe renal (kidney) impairment with an estimated creatinine clearance below 30 mL per minute.

• Nausea
• Trouble sleeping (insomnia)
• Tiredness (fatigue)
• Headache

Other General Warnings

• You have both HIV-1 and Hepatitis B infection, as stopping this medicine may worsen your Hepatitis B.
• You have liver problems or notice symptoms such as yellowing of your skin or eyes, dark urine, or pain in the upper right side of your stomach.
• You develop signs of a severe allergic reaction, such as rash, fever, blisters, swelling of the face, or difficulty breathing.
• You have kidney disease, a history of kidney transplant, or are experiencing changes in urination or kidney function.
• You experience unusual muscle pain, severe weakness, shortness of breath, or feel unusually cold in your hands and feet (possible lactic acidosis).
• Your immune system begins to change, and you develop symptoms of infection, such as fever, cough, or inflammation (immune reconstitution syndrome).

• Spegra tablet is to be taken exactly as advised by your doctor.
• Take the medicine with a glass of water. It can be taken with or without food.
• Take it at a fixed time every day for optimal results and to maintain steady medicine levels in your body.

• Store below 30°C (86°F).
• Protect from moisture by keeping it in its original container and tightly closing the bottle.
• Do not remove the desiccant packet from the bottle.
• Keep it out of the reach of children and pets.
• Do not throw away any medicines down the drain or into household waste.

• Take the tablet at the same time every day to maintain steady medicine levels in your body.
• You can take this medicine with or without food.
• Do not stop taking the medicine suddenly without consulting your doctor, even if you feel well.
• Always swallow the tablet whole with water.
• If you miss a dose, take it as soon as you remember, but do not double up on doses.
• Refill your prescription before you run out to prevent your viral load from increasing.
• Continue regular follow-up visits and blood/urine tests as advised by your doctor to monitor your kidneys and liver.
• Do not share your medicine with others.

Overdose

Missed a Dose

How Does It Work?

• Dolutegravir blocks the virus from integrating its genetic material into your immune cells.
• Emtricitabine and tenofovir alafenamide prevent the virus from replicating and growing.
• When used together in this single tablet, they effectively reduce the virus load in your bloodstream, boost your immune system, and help manage HIV-1 infection.

Interactions with other medicines

• It is crucial to tell your doctor if you are taking, have recently taken, or might take any other medicines, including herbal preparations. This medicine can interact with other medicines, altering their blood concentrations or affecting how well Spegra tablet works.
• Especially tell your doctor if you are taking:
• Dofetilide (taking these together is strictly contraindicated).
• Antacids, laxatives, buffered medications, or sucralfate containing aluminum or magnesium (must be taken 2 hours before or 6 hours after Spegra tablet).
• Oral calcium or iron supplements, including multivitamins (must be taken 2 hours before or 6 hours after Spegra tablet, unless taken together with food).
• Metformin (your doctor may need to limit your dose and monitor your blood sugar).
• Anti-seizure medications (such as carbamazepine, oxcarbazepine, phenytoin, phenobarbital).
• Herbal remedies for depression and anxiety, specifically St. John's wort (Hypericum perforatum).
• Antimycobacterials like rifampin, rifabutin, or rifapentine.
• Other HIV medicines (such as efavirenz, etravirine, nevirapine, or fosamprenavir/ritonavir).

Interactions with food items

• Spegra tablet can be taken with or without food. Taking it with food may help reduce common side effects, such as nausea.
• If you need to take calcium or iron supplements, you can take them at the exact same time as Spegra tablet only if you take them with food. If you are taking them on an empty stomach, you must space them out (2 hours before or 6 hours after Spegra tablet).
• Avoid taking herbal supplements containing St. John's wort, as this can severely lower the effectiveness of the medicine.