Rimcure 3fdc Tablets
6 Tablet(s) in StripWe do not sell this product
Made by
NOVARTIS INDIA LTD
Dosage
TABLET
Expiry
Product Summary
| Uses | Treatment of Tuberculosis |
| Side effects | Nausea, vomiting, abdominal pain, itching, headache, drowsiness, giddiness, fatigue, discolouration of urine/ secretions, liver dysfunction, kidney dysfunction, visual changes, peripheral nerve disorders |
Assurance
available
Regulated
Medical Description
Rimcure 3 FDC is a prescription medication. It is a tablet that is used in the treatment of tuberculosis. It is a fixed-dose combination of three medications, namely Rifampicin, Isoniazid, and Pyrazinamide.
Tuberculosis is a common, prevalent infectious disease in India. It is a bacterial infection. It mainly impacts the lungs but can also affect other organs. In lung TB, patients present with cough with sputum production lasting for more than two weeks, evening fevers, night sweats, and weight loss. TB is a chronic, severely debilitating infection that requires sustained treatment.
The first-line therapy of TB involves the medications Rifampicin, Isoniazid, Pyrazinamide and Ethambutol in appropriate doses. Rimcure 3 FDC combines 3 of these medicines in a fixed-dose in one tablet.
Rimcure 3 FDC should be taken as recommended by your treating physician. It is very important to complete the entire course of the medication to ensure complete treatment and prevent resistance to the medications. It is important to review routinely with your doctor while on this medication to monitor disease progression, tolerance of the medications, complications, etc.
Uses
- Treatment of Tuberculosis
Contraindications
This tablet is contraindicated in:
Hypersensitivity reactions to any of the medications, or components of this tablet
Acute liver disease (regardless of origin), History of drug-induced liver dysfunction
Severe kidney failure
Hereditary disorder called porphyria
Use in children < 8 years
In patients who weigh < 30kg
History of rare disorders which affect galactose metabolism (galactose intolerance, total lactase deficiency or glucose-galactose malabsorption)
Side effects
- Tiredness
- Drowsiness
- Headache
- Itching, Skin rashes
- Loss of appetite
- Nausea, Vomiting
- Abdominal pain
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You are on any other medications.
- Your symptoms worsen.
Directions for Use
- Rimcure 3 FDC should be taken as prescribed by the treating medical professional.
- It is recommended to take this medication at the same time each day.
- Swallow this medication as a whole. Don’t crush, chew or break this tablet.
- This medication should be taken along with other anti-tubercular medications, as recommended by your doctor.
- The entire course of this medication as prescribed by your treating doctor should be finished. Abrupt stoppage of the drug can cause the recurrence of symptoms of the disease. Consult your doctor before stopping this medication.
Storage and disposal
Store Rimcure 3 FDC in a cool and dry place, away from direct light and moisture. Don’t use the medicine after the date of expiration. Keep the tablets out of reach of children and pets. Don’t flush the medication down the toilet. Dispose of it with biomedical waste only.
Dosage
Overdose
As this is a combination of multiple medications, an overdose can present in multiple ways. Possible presenting symptoms can include nausea, vomiting, abdominal pain, pruritus, headache, increasing lethargy, and unconsciousness when severe hepatic disease, hypotension, sinus tachycardia, ventricular arrhythmias, seizures, hallucinations, respiratory depression, apnoea and cardiac arrest.
Shift the patient to an emergency care centre for further evaluation and treatment.
Missed a Dose
If you miss a dose of this tablet, it is advised to take it as soon as possible. If it is almost time for the next dose, it is recommended to skip the missed dose and go back to the regular schedule. Do not double the dose of the tablet.
Mode of Action
How Does It Work?
The first-line therapy of TB involves the medications Rifampicin, isoniazid, pyrazinamide and ethambutol in appropriate doses. Rimcure 3 FDC combines 3 of these medicines in a fixed-dose in one tablet. Rifampicin works by blocking a bacterial enzyme called RNA Polymerase that is essential for the synthesis of proteins and reproduction of the bacteria, thereby destroying it.
Isoniazid works by acting on a chemical called Mycolic acid present in the outer protective layer of the bacteria called the cell wall, thereby making the bacteria more vulnerable to immune responses. Pyrazinamide works by triggering processes that destroy the bacteria, such as blocking the synthesis of an enzyme called Co-enzyme A, resulting in the prevention of bacterial growth.
Interactions
Interactions with other medicines
- Rifampicin is a potent inducer of a particular enzyme system involved in metabolising many medications. Concurrent use will hence decrease the efficacy of the other medicines.
- Antacids reduce the amount of rifampicin and isoniazid absorbed from the gut to the bloodstream. To avoid this, Rimcure 3 FDC should be taken at least 1 hour before medications that lower stomach acid levels.
- Corticosteroids can reduce the blood levels of isoniazid as the medication gets metabolised faster.
- Rifampicin may result in altered levels of morphine in patients who need chronic pain medication. The dose must be adjusted accordingly.
- Rifampicin and pyrazinamide may reduce the effectiveness of oral contraceptives. Patients treated with Rimcure 3 FDC should use an alternate method of contraception.
- This medication decreases the effect of medicines used to treat gout, such as probenecid and sulfinpyrazone, which are uricosuric agents (increase the excretion of uric acid from the body).
Interactions with food items
- This medication is recommended to be taken 30 mins before food or 2 hours after food.
- Food items rich in tyramine, and histamines, such as certain types of meats and cheese, wine, beer and fish (e.g. salmon), should be avoided.
- This is because Isoniazid can decrease the metabolism of tyramine and histamine, resulting in side effects like headache, sweating, flushing, heart palpitations, and fall in blood pressure.
Frequently Asked Questions (FAQs)
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Vendor Details
Fulfillment Information: Rimcure 3fdc Tablets will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.
References:
- Padda IS, Muralidhara Reddy K. Antitubercular Medications. [Updated 2021 Nov 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from:
- Zhang, Y., Shi, W., Zhang, W., & Mitchison, D. (2013). Mechanisms of Pyrazinamide Action and Resistance. Microbiology spectrum, 2(4), 1–12.
- O'Connor C, Brady MF. Isoniazid. [Updated 2022 Jan 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from
- Beloor Suresh A, Rosani A, Wadhwa R. Rifampin. [Updated 2022 Jan 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from:
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Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
