Marks Rub Ultra Cream
Description
Marks Rub Ultra Cream is a prescription medicine used to treat moderate to severe melasma, which appears as dark or discoloured patches on the skin, most commonly on the face. It helps lighten pigmentation and improve overall skin tone, especially when dark spots are caused by excess melanin production. It may also be used for age-related dark spots due to long-term sun exposure.
This cream contains three active ingredients: hydroquinone, tretinoin, and mometasone. Hydroquinone works by reducing the formation of melanin, the pigment responsible for dark patches. Tretinoin, a form of vitamin A, helps remove existing pigmentation by increasing skin cell turnover, while mometasone reduces redness, swelling, and irritation by controlling inflammation in the skin.
Marks Rub Ultra Cream should be applied exactly as prescribed by your doctor, usually as a thin layer on the affected area. It is important to avoid sun exposure after applying the cream, as the skin becomes more sensitive to sunlight. Using a broad-spectrum sunscreen and covering the treated area when outdoors helps protect the skin and improves treatment results.
This cream is meant for short-term use only. Prolonged or excessive application can cause side effects such as skin thinning, irritation, or hormonal effects. Avoid applying it on broken, infected, or irritated skin, and keep it away from the eyes, nose, and mouth. Always consult your doctor if you notice worsening pigmentation, irritation, or any unusual skin changes during treatment.
Product Summary
| Offer Price | ₹112.42 |
| You Save | ₹41.58 (27% on MRP) |
| Contains | Tretinoin(0.025 %W/W)+Mometasone(0.1 %W/W)+Hydroquinone(2.0 %W/W) |
| Uses | Melasma |
| Side effects | Itching, redness, burning, irritation, thinning of the skin |
| Therapy | DRUGS FOR MELASMA |

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Uses
Contraindications
- If you are allergic to mometasone, tretinoin and hydroquinone or any other ingredients of Marks Rub Ultra Cream.
- If you have skin conditions such as eczema (infected skin due to allergy), rosacea (small red pustules on face), rashes around the mouth (perioral dermatitis) or damaged skin anywhere in the body.
- If you have a viral or fungal infection of the skin, any ulcers on the skin or tuberculosis.
- If you need exposure to the sun for prolonged periods (using sunscreen lotion is advisable).
- If you have a skin tumour or a family history of skin tumour.
Side effects
- Itching, redness, burning, irritation and thinning of the skin.
- Skin sensitivity at the site of application.
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You have a history of allergic reactions after the application of topical Creams.
- You are pregnant or breastfeeding.
- You think rashes or infections have developed on the skin after using this medicine.
- A prolonged application may lead to side effects such as Cushing's syndrome (weight gain, fatty deposits under the skin, moon face, purple patches on the skin), increased sugar levels in the blood and urine....
- Avoid exposure to sun rays as it may be harmful after applying this Cream.
Directions for Use
- Use Marks Rub Ultra Cream as directed by your doctor.
- Apply it on a healthy skin surface. Avoid applying on cuts and wounds.
- Wash your hands before and after using this medicine unless your hands are the area to be treated.
- If your eyes come in contact with this Cream, then rinse your eyes with clean water immediately.
Storage and disposal
- Store Marks Rub Ultra Cream in the original container in a clean and dry place, protected from moisture, sunlight and heat.
- Keep the medicine away from children and pets.
- Do not freeze.
Quick Tips
- Apply a thin layer and rub gently until fully absorbed.
- Avoid contact with eyes, mouth, and open wounds.
- Limit sun exposure and use broad-spectrum sunscreen.
- Do not cover treated areas with bandages or plastic wrap.
- Follow your doctor’s instructions; avoid prolonged use.
- Wash hands before and after application.
- Conduct a patch test on a small skin area before full use.
Dosage
Overdose
Missed a Dose
Mode of Action
How Does It Work?
- Marks Rub Ultra Cream contains a combination of Mometasone, Tretinoin and Hydroquinone as active ingredients and works by the combined action of these three components.
- Hydroquinone inhibits an enzyme known as tyrosinase, which is responsible for the production of a pigment called melanin. Melanin is responsible for skin pigmentation and melasma.
- Tretinoin is a metabolite of vitamin A. It is responsible for the elimination of melanin that has been formed. It also has anti-inflammatory properties.
- Mometasone is a corticosteroid and it works by blocking the production of inflammatory chemicals like prostaglandins and leukotrienes. Mometasone narrows and constricts blood vessels, which are dilated (widened) and leaky and allowing other inflammatory cells into the skin to promote the inflammatory response....
Interactions
Interactions with other medicines
- Since Marks Rub Ultra Cream is to be used externally on the skin, it is less likely to interact with other medicines. However, always consult your doctor if you are taking other medicines for treating other health conditions....
- You should always tell the doctor if you are taking any other medicines, herbal preparation and supplements to avoid interaction with Marks Rub Ultra Cream.
Interactions with food items
- Marks Rub Ultra Cream is for external use only, so it does not interact with food.
- You can eat your normal diet while using this cream.
- Limiting excessive spicy or oily foods may help reduce skin irritation.
- Staying hydrated supports better skin health and treatment results.
- Follow your doctor’s advice on sun protection for optimal effectiveness.
Content Details
Dr. Mansi Savla
B. Pharm, PharmD
Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: How should I use Marks Rub Ultra Cream?
- Apply it gently as a thin film and rub or massage it thoroughly after applying until the Cream absorbs into the skin.
- Exposure to the sun should be avoided and use a broad-spectrum sunscreen to prevent the sun's radiation from reaching your skin.
- Do not use this Cream more than as advised by the doctor. This Cream should not be used for a prolonged duration to avoid side effects such as skin thinning, irritation, etc.
Q: What are the precautions to be taken while applying Marks Rub Ultra Cream?
- Do not apply anywhere near the eyes, nose, mouth or any infected or exposed surfaces.
- Do not occlude (applying a polythene film) after applying this Cream or use it under bandages.
- Limit sun exposure and use a broad-spectrum sunscreen while going out in the sun to avoid damage to the skin by radiations.
- You should cover the areas of skin where this medicine is applied when outdoors.
Q: What is melasma?
Q: What are the causes of melasma?
References
- CDSCO [Internet]. Cdscoonline.gov.in.[cited 17 April 2025].
- Drugs H. Tretinoin Topical: MedlinePlus Drug Information [Internet]. Medlineplus.gov. [cited 17 April 2025].
- Mometasone-based triple combination therapy in melasma: is it really safe. [Internet]. [cited 17 April 2025].
- Drugs H. Mometasone Topical: MedlinePlus Drug Information [Internet]. Medlineplus.gov. [cited 17 April 2025].
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