Macrozide 500mg Tablet
Macrozide 500 MG Description
Macrozide 500 mg tablet is a prescription medicine used to treat tuberculosis or TB infection, a serious bacterial infection that mainly affects the lungs. The active ingredient in Macrozide 500 mg t
ablets is pyrazinamide. Macrozide tablet is an anti-TB medication. The mode of action of Macrozide 500 mg tablets is by preventing the effect of specific proteins in the bacteria. Pyrazinamide in this medicine has an unusual mechanism of action in that it does not directly block the action of these proteins but indirectly triggers their destruction. This medicine is generally prescribed for a few months at least because TB bacteria are hard to kill and die very slowly. The duration depends on numerous aspects, one of which is the severity of the infection. Macrozide tablets are often used with other anti-TB medications since TB bacteria form resistance to antibiotics easily. Directions for use of Macrozide 500 mg tablets should be strictly followed. It is essential that the complete course of treatment is completed. Midway stoppage can result in reinfection, and the bacteria may even develop resistance to the current regimen.
|Side effects||Stomach upset, Nausea, Vomiting, Itching, Fever, Loss of appetite, Salivation, Excess sputum, Blurred vision, Joint swelling, Joint pain, Gout|
Uses of Macrozide 500 MG
- As per CDSCO, Macrozide tablets are used to treat tuberculosis (TB) infection, mainly in the lungs and in some rare cases in other parts of the body.
Contraindications of Macrozide 500 MG
Side effects of Macrozide 500 MG
- Side effects of Macrozide tablets include:
- Joint pains
- Burred or loss of vision
- Skin rash
- Nausea or vomiting
- Weight loss
- Bleeding or bruising
Precautions and Warnings of Macrozide 500 MG
Other General Warnings
- You had tuberculosis (TB) previously and used Macrozide tablets for treatment.
- You want to stop using Macrozide tablets because you feel better. Do not stop the treatment midway. This can cause a TB -reinfection and make it harder to fight the bacteria.
- You are on oral birth control pills. Macrozide medicine reduces its effectiveness, especially when used with other TB medicines. Use other contraceptive methods like condoms, diaphragms, etc.
- You take antacids regularly. Avoid taking antacids immediately after taking a Macrozide tablet.
- You have diabetes. Macrozide tablets can cause fluctuations in blood sugar levels.
Mode of Action of Macrozide 500 MG
How Does It Work?
Directions for Use of Macrozide 500 MG
- Take Macrozide tablets exactly as advised by the doctor for the entire prescribed duration.
- Take this medicine 1 to 2 hours before meals.
- Do not exceed the prescribed dose.
- Try to take this tablet as a whole with a glass of water. Do not try to break or chew it.
- Do not take Macrozide tablets if their packaging is broken.
- Do not suddenly stop taking this tablet. This can cause reinfection or medicine resistance.
- Notify your doctor if you want to take other medications with Macrozide tablets.
Interactions of Macrozide 500 MG
Interactions with other medicines
- Gout medicine like allopurinol, colchicine, and probenecid interfere with Macrozide tablets.
- Macrozide tablets increase the blood levels of phenytoin (anti-seizure medicine) and disulfiram (for alcohol addiction), which can cause adverse effects.
- Macrozide tablets lower the medicine levels of blood thinners (warfarin), birth control pills, certain diabetic medicines (sulfonylureas), etc.
- Using Macrozide tablets with a second-line of TB medicines like ethionamide can increase the side effects.
Interactions with food items
- Food can interfere with the effectiveness of Macrozide tablets. Take it on an empty stomach. If you experience severe stomach upset, have them after a meal.
- Avoid caffeine, sodium, spicy condiments, processed sugar, and flour. Foods containing saturated and trans fats worsen tuberculosis (TB) symptoms of diarrhoea, abdominal cramps, and fatigue.
- Tobacco should be avoided during the treatment of TB infection.
- If you are using other TB medicines with this tablet, try to avoid foods with high tyramine content, such as aged cheese, cured meat, soy sauce, beer, red wine, etc.
Storage and disposal of Macrozide 500 MG
Dosage of Macrozide 500 MG
Missed a Dose
Dr. Vijay Y
MBBS, MD in Clinical Pharmacology
Frequently Asked Questions (FAQs)
Q: Can I use antacid medicines while using Macrozide 500 mg tablets?
Q: Can I stop using the Macrozide 500 mg tablet if I feel better and don't have symptoms?
Q: Can Macrozide 500 mg tablets be prescribed to children?
- Pyrazinamide: MedlinePlus drug information [Internet]. MedlinePlus. U.S. National Library of Medicine; [cited 21 Mar 2022]
- Peloquin CA, Bulpitt AE, Jaresko GS, Jelliffe RW, James GT, Nix DE. Pharmacokinetics of pyrazinamide under fasting conditions, with food, and with antacids [Internet]. Pharmacotherapy. U.S. National Library of Medicine [cited 21 Mar 2022]
- Chang KC, Yew WW, Sotgiu G. Clinical research in the treatment of tuberculosis: Current status and future prospects [Internet]. The international journal of tuberculosis and lung disease: The official journal of the International Union against tuberculosis and lung disease. U.S. National Library of Medicine [cited 21 Mar 2022] -
- Torres NMC, Rodríguez JJQ, Andrade PSP, Arriaga MB, Netto EM. Factors predictive of the success of tuberculosis treatment: A systematic review with meta-analysis [Internet]. PLOS ONE. Public Library of Science [cited 21 Mar 2022] -
- Tuberculosis [Internet]. National Institute of Allergy and Infectious Diseases. U.S. Department of Health and Human Services [cited 21 Mar 2022]
- New Drugs Approved by CDSCO [Internet]. cdscoonline.gov.in. 2022 [cited 21 Mar 2022] -