Macrozide 500mg Tablet

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Macrozide 500 MG Description

Macrozide 500 mg tablet is a prescription medicine used to treat tuberculosis or TB infection, a serious bacterial infection that mainly affects the lungs. The active ingredient in Macrozide 500 mg t

ablets is pyrazinamide. Macrozide tablet is an anti-TB medication. The mode of action of Macrozide 500 mg tablets is by preventing the effect of specific proteins in the bacteria. Pyrazinamide in this medicine has an unusual mechanism of action in that it does not directly block the action of these proteins but indirectly triggers their destruction. This medicine is generally prescribed for a few months at least because TB bacteria are hard to kill and die very slowly. The duration depends on numerous aspects, one of which is the severity of the infection. Macrozide tablets are often used with other anti-TB medications since TB bacteria form resistance to antibiotics easily. Directions for use of Macrozide 500 mg tablets should be strictly followed. It is essential that the complete course of treatment is completed. Midway stoppage can result in reinfection, and the bacteria may even develop resistance to the current regimen.

Product Summary

Offer Price	₹24.19
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Contains	Pyrazinamide(500.0 Mg)
Uses	Tuberculosis infection
Side effects	Stomach upset, Nausea, Vomiting, Itching, Fever, Loss of appetite, Salivation, Excess sputum, Blurred vision, Joint swelling, Joint pain, Gout
Therapy	ANTI-TUBERCULAR

Check more medicines with composition as Pyrazinamide(500.0 Mg)

Precautions and Warnings

Uses of Macrozide 500 MG

As per CDSCO, Macrozide tablets are used to treat tuberculosis (TB) infection, mainly in the lungs and in some rare cases in other parts of the body.

Contraindications of Macrozide 500 MG

Do not take Macrozide tablets, or caution: If you have a history of allergy to any of the components of a Macrozide tablet. If you have a history of visual disorders like optic neuritis; Macrozide t...

Side effects of Macrozide 500 MG

Side effects of Macrozide tablets include:
Chills
Joint pains
Burred or loss of vision
Skin rash
Nausea or vomiting
Weight loss
Bleeding or bruising

Precautions and Warnings of Macrozide 500 MG

Pregnancy

Can I take Macrozide 500 mg tablets during pregnancy?

If you are pregnant and diagnosed with tuberculosis infection, take your medication as prescribed by the doctor. It is natural to worry about the health of your child but not taking anti-TB medicines can cause more severe infections and sometimes death. Macrozide tablets medicine may reach the baby, but studies have not shown any foetal problems.

Breast Feeding

Can I take Macrozide 500 mg tablets while breastfeeding?

It is advised that Macrozide tablets be used with caution in nursing mothers, taking into account the risk-benefit ratio of this therapy. Some amount of Macrozide tablets may pass into breast milk. Please consult your doctor before starting Macrozide pills if you are breastfeeding your child.

Driving

Is it ok to drive after taking a Macrozide 500 mg tablet?

There is insufficient data on the safety of Macrozide tablets while driving. If you experience side effects like dizziness or blurred vision, do not drive until they pass.

Alcohol

Can I consume alcohol with Macrozide 500 mg tablets?

Try not to consume too much alcohol with Macrozide tablets, as it can interfere with the effects of this medicine.

Other General Warnings

Talk to your doctor if

You had tuberculosis (TB) previously and used Macrozide tablets for treatment.
You want to stop using Macrozide tablets because you feel better. Do not stop the treatment midway. This can cause a TB -reinfection and make it harder to fight the bacteria.
You are on oral birth control pills. Macrozide medicine reduces its effectiveness, especially when used with other TB medicines. Use other contraceptive methods like condoms, diaphragms, etc.
You take antacids regularly. Avoid taking antacids immediately after taking a Macrozide tablet.
You have diabetes. Macrozide tablets can cause fluctuations in blood sugar levels.

Mode of Action of Macrozide 500 MG

How Does It Work?

Macrozide tablets have only one active component: pyrazinamide. This medicine slows the growth of tuberculosis (TB) bacteria by preventing the effect of specific proteins in the bacteria. Pyrazinami...

Directions for Use of Macrozide 500 MG

Take Macrozide tablets exactly as advised by the doctor for the entire prescribed duration.
Take this medicine 1 to 2 hours before meals.
Do not exceed the prescribed dose.
Try to take this tablet as a whole with a glass of water. Do not try to break or chew it.
Do not take Macrozide tablets if their packaging is broken.
Do not suddenly stop taking this tablet. This can cause reinfection or medicine resistance.
Notify your doctor if you want to take other medications with Macrozide tablets.

Interactions of Macrozide 500 MG

Interactions with other medicines

Gout medicine like allopurinol, colchicine, and probenecid interfere with Macrozide tablets.
Macrozide tablets increase the blood levels of phenytoin (anti-seizure medicine) and disulfiram (for alcohol addiction), which can cause adverse effects.
Macrozide tablets lower the medicine levels of blood thinners (warfarin), birth control pills, certain diabetic medicines (sulfonylureas), etc.
Using Macrozide tablets with a second-line of TB medicines like ethionamide can increase the side effects.

Interactions with food items

Food can interfere with the effectiveness of Macrozide tablets. Take it on an empty stomach. If you experience severe stomach upset, have them after a meal.
Avoid caffeine, sodium, spicy condiments, processed sugar, and flour. Foods containing saturated and trans fats worsen tuberculosis (TB) symptoms of diarrhoea, abdominal cramps, and fatigue.
Tobacco should be avoided during the treatment of TB infection.
If you are using other TB medicines with this tablet, try to avoid foods with high tyramine content, such as aged cheese, cured meat, soy sauce, beer, red wine, etc.

Storage and disposal of Macrozide 500 MG

Side effects of Macrozide tablets include: Chills Joint pains Burred or loss of vision Skin rash Nausea or vomiting Weight loss Bleeding or bruising

Dosage of Macrozide 500 MG

Overdose

Take Macrozide tablets exactly as advised by the doctor for the entire prescribed duration. Take this medicine 1 to 2 hours before meals. Do not exceed the prescribed dose. Try to take this tablet as ...

Missed a Dose

Food can interfere with the effectiveness of Macrozide tablets. Take it on an empty stomach. If you experience severe stomach upset, have them after a meal. Avoid caffeine, sodium, spicy condiments, ...

Content Details

WRITTEN BY

Dr. Aashritha Pilli

MBBS

REVIEWED BY

Dr. Vijay Y

MBBS, MD in Clinical Pharmacology

Frequently Asked Questions (FAQs)

Q: Can I use antacid medicines while using Macrozide 500 mg tablets?

A: It is generally not recommended to use both of these medicines at the same time. Do not take antacids within two hours of taking Macrozide tablets, as antacids can lower the effectiveness of this medicine.

Q: Can I stop using the Macrozide 500 mg tablet if I feel better and don't have symptoms?

A: Do not stop using Macrozide tablets mid-treatment, even if you feel better. TB bacteria die very slowly, and it takes a long time to remove them completely. If you stop the medicines midway, the bacteria will multiply again and may gain resistance to the current treatment. This causes reinfection and makes it even harder to kill the bacteria.

Q: Can Macrozide 500 mg tablets be prescribed to children?

A: Yes, this tablet is considered safe in children along with other first-line medicines for TB infection. However, they should be given this medication only after consulting with a doctor.

References

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Product Details

Brand

MACROZIDE

Expires on or After

17/07/2024

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Last Updated on: 06 Apr 2022 | 05:57 PM (IST)

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