Esofag-D Capsule

• Esofag-D capsule is used in adult patients to treat gastroesophageal reflux disease (GERD) in which there is a reflux of acid from the stomach into the food pipe.
• It is also used to treat the associated symptoms like heartburn, chest discomfort, and acidity.

• If you are allergic to esomeprazole, domperidone, or any other ingredients of Esofag-D capsule.
• If you have a blockage or tear in the intestines.
• If you are suffering from liver or kidney disorder.
• If you are suffering from bleeding in the digestive system.
• If you have any tumour of the pituitary gland.
• If you have severe heart problems such as congestive heart failure, heart rhythm problems, electrolyte imbalance.
• If you are taking any medicine which might affect the contraction of the heart muscle (QT prolongation).
• If you are taking medicines such as nelfinavir (used in HIV infection), clarithromycin (antibiotic), ketoconazole (antifungal), or verapamil (used in high blood pressure and chest pain). If you are not sure what these medicines are, please confirm with your doctor.

• Headache
• Dizziness
• Nausea
• Vomiting
• Rashes

Other General Warnings

• You have any liver or kidney-related diseases.
• You experience black stools or have a stomach tumour.
• You have a history of fractures or have osteoporosis or are taking steroids.
• You develop skin lesions, especially in the sun-exposed area after taking this medicine.
• You are taking medicines to treat HIV or apomorphine (used to treat muscle stiffness).
• You have heart problems and associated symptoms like palpitations, difficulty in breathing, and unconsciousness.
• You experience stomach pain or indigestion, unexplained weight loss, have problems while swallowing, and vomiting food or blood after taking this medicine.
• You have low levels of vitamin B12.
• You are on these capsules for long-term treatment (more than three months).
• You develop infections after taking this medicine.

• Esofag-D capsule should be taken at least 1 hour before meals.
• This capsule should be taken as prescribed by the doctor.
• Swallow it as a whole with a glass of water.
• Do not cut, break or chew the medicine.
• It would be best if you take it at a fixed time for optimal results.
• Do not consume more than the dose prescribed by your doctor.

• Store Esofag-D capsule below 25°C in a clean and dry place, protected from direct sunlight, moisture, and heat.
• Keep this medicine away from children and pets.

Overdose

Missed a Dose

How Does It Work?

• Esofag-D capsule contains a combination of two medicines - esomeprazole and domperidone as active substances.
• A pump called the proton pump in the stomach is responsible for the flow of stomach acids. Esomeprazole works by binding to this proton pump in stomach cells and blocking the acid secretion.
• Domperidone acts by increasing the motility of the stomach and intestines so that acid does not reflux back into the food pipe.

Interactions with other medicines

• Some medicines affect the way Esofag-D capsule works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
• Inform your doctor about all medicines, supplements, or herbals you are currently taking or might take to avoid possible interaction.
• This medicine should not be taken concomitantly along with medicines such as nelfinavir (used to treat HIV infection), amiodarone (used to treat muscle stiffness), clarithromycin (antibiotic), ketoconazole (antifungal), or verapamil (used in high blood pressure, chest pain).
• This capsule should also not be taken along with medicines used to treat heart problems (quinidine, sotalol), psychiatric illness (haloperidol, citalopram), antifungals (pentamidine), antimalarials (halofantrine, lumefantrine), medicines used to treat allergies (mizolastine), medicines to treat cancer (toremifene, vandetanib), gastric emptying medicines (cisapride) and other medicines like diphemanil and methadone.
• Concomitant use of this capsule with medicines used to treat psychiatric illness (diazepam), used to treat fits (phenytoin) is not recommended as it may increase the side effects of the medicines.
• Medicine used to treat heart failure like digoxin may lead to toxicity when taken with this medicine.
• If you are taking warfarin (blood-thinner) along with this medicine, caution is needed as there are chances of increased bleeding.
• Other medicines like rifampicin, methotrexate, tacrolimus, voriconazole, cilostazol, clopidogrel, azithromycin, St.John's wort should be used cautiously along with Esofag-D capsule.