Envira 40 Mg Injection 0.8 Ml

• Envira Injection is used in the management of:
• Rheumatoid Arthritis (A chronic autoimmune disease that causes pain, swelling, and stiffness in the joints).
• Juvenile Idiopathic Arthritis (Long-term inflammatory arthritis affecting children).
• Psoriatic Arthritis (Inflammation of the joints associated with psoriasis).
• Hidradenitis Suppurativa (A chronic skin condition causing painful lumps, abscesses, and tunnels, usually in skin folds.).
• Crohn’s Disease (A chronic inflammatory bowel disease that can affect any part of the digestive tract).
• Ulcerative Colitis (A chronic inflammatory bowel disease affecting the lining of the colon and rectum).
• Psoriasis (A chronic skin condition causing red, scaly, and inflamed patches).
• Paediatric Plaque Psoriasis (a condition causing thick, scaly skin patches).
• Paediatric Crohn’s Disease (Crohn’s disease affecting children, causing inflammation in the digestive tract).
• Uveitis (Inflammation of the uvea, the middle layer of the eye, which may cause eye pain, redness, or vision problems).
• Paediatric Uveitis (Uveitis occurring in children and causing inflammation inside the eye).
• Paediatric Ulcerative Colitis (Ulcerative colitis affecting children, causing inflammation and ulcers in the colon and rectum).
• Ankylosing Spondylitis (A type of inflammatory arthritis mainly affecting the spine and sacroiliac joints).
• Non-radiographic Axial Spondyloarthritis (Inflammatory arthritis affecting the spine and pelvic joints without definite structural changes visible on X-rays).

• If you are allergic to adalimumab or any other ingredients of the injection.

• Infections, such as upper respiratory infection and sinusitis
• Injection site reactions (redness, itching, bleeding, pain, or swelling)
• Headache
• Rash
• Flu-like symptoms
• Nausea
• Abdominal pain
• Urinary tract infection
• Back pain
• High blood pressure
• High cholesterol or lipid levels
• Blood in urine
• Increased liver enzymes (ALT), increased alkaline phosphatase
• Accidental injury

Other General Warnings

• You have an active infection, or a chronic or recurring infection.
• You have been exposed to tuberculosis, or have lived in or traveled to areas where TB or fungal infections are common.
• You have hepatitis B or are a carrier of the hepatitis B virus.
• You have or have had cancer, or you have had prolonged immunosuppressant treatment.
• You have or have had a history of heart failure.
• You have or have had a nervous system disorder such as multiple sclerosis or Guillain-Barré syndrome.
• You develop signs of a blood disorder, such as persistent fever, bruising, bleeding, or paleness.
• You develop a lupus-like illness or signs of liver problems.
• You are 65 years of age or older (serious infections and cancers were more frequent in this age group, so close monitoring is needed).

• Envira Injection is given as an injection under the skin (subcutaneously), into the thigh or abdomen by a trained healthcare professional in the doses recommended by your doctor.
• It is recommended to use a different site for each injection, and do not inject into skin that is tender, bruised, red, or hard.
• Patients should never attempt to change, delay, skip, or repeat a dose on their own.

• Envira Injection is kept in a refrigerator (2°C – 8°C). Do not freeze.
• The hospital or clinic pharmacy stores and handles the medicine.

• Getting tested for tuberculosis is necessary before starting treatment and at intervals during the process, even if the initial test is negative.
• Immediately inform your healthcare team if you experience fever, chills, cough, or other infection symptoms.
• During treatment, avoid live vaccines and consult your doctor before any immunizations.
• If possible, ensure children are current on their immunizations before beginning.
• Regular skin checks are important to detect skin cancer, especially if you've had long-term immunosuppressant or PUVA therapy for psoriasis.
• Inform your doctor if you have hepatitis B or are a carrier of the virus. Also, report any unusual bruising, bleeding, pallor, or persistent fever.

Overdose

Missed a Dose

Interactions with other medicines

• Using Envira Injection with abatacept or anakinra is not recommended, because it increases the risk of serious infections.
• Using Envira Injection with other biologic DMARDs or other TNF blockers is not recommended due to a possible increase in the risk of infections and other interactions. A higher rate of serious infections has been seen in rheumatoid arthritis patients treated with rituximab who then received a TNF blocker.
• Live vaccines should be avoided while on Envira Injection.
• Azathioprine or 6-mercaptopurine used together with a TNF blocker has been linked to a rare, aggressive lymphoma (hepatosplenic T-cell lymphoma). Use this combination with caution.
• Envira Injection may affect CYP450 enzymes, which help break down some medicines. If you start or stop Envira Injection while taking medicines such as warfarin, cyclosporine, or theophylline, your doctor may monitor their effects or blood levels and adjust the dose if needed.
• Patients should tell their doctor about all prescription medicines, over-the-counter medicines, supplements, and herbal products they are taking before and during Envira Injection treatment.