Brillo Tablet

• If you are allergic to bempedoic acid or any other ingredients in Brillo tablet.
• If you are pregnant.
• If you are breastfeeding.
• If you are taking more than 40 mg of simvastatin daily.

• Anaemia
• Gout
• Pain in extremity

Other General Warnings

• You are taking statins, as Brillo tablet can increase the risk of muscle problems like myopathy or, in rare cases, severe muscle breakdown (rhabdomyolysis). Report any unexplained muscle pain, tenderness, or weakness immediately.
• You have a history of gout or high uric acid, as Brillo tablet may raise uric acid levels and trigger gout attacks.
• You have liver problems, as Brillo tablet may increase liver enzymes. Regular liver function tests may be needed, and treatment may be stopped if elevations persist.
• You have severe kidney problems, as there is limited experience with Brillo tablet in patients with severe renal impairment or on dialysis.
• You have severe liver disease, as patients with severe hepatic impairment have not been studied, and periodic monitoring may be needed.
• You are a woman of childbearing potential, as effective contraception is recommended while using Brillo tablet. Notify your doctor if you plan to become pregnant or become pregnant during treatment.

• Brillo tablet should be taken as directed by your doctor.
• Swallow it whole with a glass of water.
• It should be taken with or after a meal to reduce its side effects.
• It is best to take it at a fixed time for optimal results, and you should not consume it more than prescribed by your doctor.

• Store Brillo tablet in a cool, dry place, protected from direct sunlight, moisture, and heat.
• Keep it out of the reach of children and pets.

• Take Brillo tablet exactly as prescribed by your doctor.
• Try to take it at the same time every day to maintain consistent blood levels.
• Swallow the tablet whole with water; do not crush or chew it.
• Continue following a healthy diet low in cholesterol and saturated fats.
• Inform your doctor about any unexplained muscle pain, weakness, or tenderness.
• Have periodic blood tests as advised to monitor liver function, uric acid, and cholesterol levels.
• Avoid exceeding the prescribed dose.
• Store the tablets in a cool, dry place, away from direct sunlight and out of reach of children.
• Do not stop taking the medicine without consulting your doctor, even if you feel well.
• Report any side effects, such as joint pain, nausea, or signs of gout, to your physician promptly.

Overdose

Missed a Dose

How Does It Work?

Interactions with other medicines

• Bempedoic acid typically does not interact with most medications; however, its glucuronide form is a substrate for OAT3, which can affect certain drugs.
• Probenecid can slightly increase bempedoic acid levels, but the change is not clinically important and does not require dose adjustment.
• Taking bempedoic acid with statins such as simvastatin, atorvastatin, pravastatin, or rosuvastatin can increase statin levels, particularly simvastatin, which may increase the risk of muscle-related side effects.
• Bempedoic acid can weakly inhibit the liver transporters OATP1B1 and OATP1B3, which may increase plasma concentrations of drugs processed by these transporters, including certain statins and antiviral medications.
• Bempedoic acid may raise uric acid and creatinine levels by blocking OAT2 and weakly inhibiting OAT3, which can affect drugs that use these transporters.
• Bempedoic acid can slightly increase levels of ezetimibe and its glucuronide, but the change is not clinically significant and does not require dose adjustment.
• Bempedoic acid does not significantly affect metformin or hormonal contraceptives containing norethindrone/ethinyl estradiol.

Interactions with food items

• There are no known food interactions with Brillo tablet.
• It can be taken with or without food.
• Maintaining a consistent diet low in cholesterol and saturated fats will help the medicine work better.
• Avoid excessive alcohol, as it may affect liver health and overall cholesterol management.
• Continue following any dietary instructions provided by your physician while taking Brillo tablet.