Aculip H Tablets
By SHINE PHARMACEUTICALS LTD
20 Tablet(s) in Strip
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Aculip H Tablets Description
Aculip H is a prescription medication used to assist in depression and associated anxiety. It is a combination of Amitriptyline (5mg) and Chlordiazepoxide (12.5mg). This combination is utilised to tr
eat moderate to severe depression and anxiety. The medication should be taken as recommended by the doctor. It is generally advisable to take the tablet at the same time every day as this ensures the most efficacious action of the medication and decreases the chances of relapse of symptoms significantly. It is also recommended to complete the entire course of the medicine as prescribed by the treating physician and not abruptly stop taking the medication.
Product Summary
| Offer Price | ₹64.42 |
| You Save | ₹8.78 (12% on MRP) |
| Contains | Amitriptyline(5.0 Mg) + Chlordiazepoxide(12.5 Mg) |
| Uses | Treatment of Major Depressive Disorder with moderate to severe anxiety |
| Side effects | Constipation, urinary retention, weight gain, confusion, orthostatic hypotension (sudden lowering of blood pressure on standing), tiredness, blurred vision, dryness in mouth, increased heart rate, uncoordinated body movements, memory impairment |
| Therapy | ANTI-DEPRESSANT |
Check more medicines with composition as Amitriptyline(5.0 Mg) + Chlordiazepoxide(12.5 Mg)
Uses of Aculip H Tablets
- Major depressive disorder (MDD)
- Moderate to severe anxiety
Contraindications of Aculip H Tablets
- Hypersensitivity reactions.
- Recent history of arrhythmias, myocardial infarction, heart failure, or QTc prolongation.
- Angle closure glaucoma.
- Epilepsy/seizure disorders patients.
- Pulmonary diseases.
- Pregnancy
- Breastfeeding
- Intention to conceive
Side effects of Aculip H Tablets
- Constipation
- Urinary retention
- Dry mouth
- Orthostatic hypotension (unanticipated lowering of blood pressure on standing up)
- Dizziness
- Blurred vision
- Acute angle glaucoma
- Confusion
- Increased appetite
- Weight gain
- Decrease of seizure threshold in patients with epilepsy/ seizure disorder
- Increased risk of bone fractures
- Increased suicidal ideation in young adults
- Fatigue
- Ataxia
- Slurred speech
- Weakness
- Skin eruptions
- Menstrual irregularities
Precautions and Warnings of Aculip H Tablets
Pregnancy
Q:
Can I take Aculip H during pregnancy?
A:
No, this medication is unsafe in pregnancy and should not be taken while pregnant or if the person intends to conceive. Consult your doctor, and inform them regarding your health status.
Breast Feeding
Q:
Can I take Aculip H while breastfeeding?
A:
This medication is generally not advised while breastfeeding. Discuss with your doctor for more information.
Driving
Q:
Can I drive if I have taken Aculip H?
A:
Driving and operating other heavy machinery while on this medication is not recommended as it may cause sedation and drowsiness.
Alcohol
Q:
Can I consume alcohol with the Aculip H?
A:
Alcohol consumption while on this medication is contraindicated as it may cause increased sedation and other adverse effects.
Mode of Action of Aculip H Tablets
How Does It Work?
Amitriptyline belongs to a class of medications called Tricyclic antidepressants (TCAs) that acts on multiple brain pathways to increase levels of certain neurotransmitters. It works by preventing the re-uptake of both serotonin as well as nor-adrenaline. It also has more sedating properties when compared to other TCAs.
The action of this medication typically begins within 2 to 4 weeks. Long term treatment with this antidepressant has shown to increase the levels of BDNF (brain-derived neurotrophic factor). BDNF plays a vital role in brain development. Studies have shown that in Major Depressive Disorder, stress-related changes in BDNF levels occur. As continued use of this medication increases BDNF levels, it reduces the symptoms of Major Depressive Disorder.
Chlordiazepoxide belongs to a class of medications called benzodiazepines. It produces sedating and calming effects in users by acting on the brain to increase the inhibitory effects of a neurotransmitter called GABA (gamma-aminobutyric acid).
The therapeutic benefits of Chlordiazepoxide in anxiety disorder come from the inhibition of activity in fear circuits in the part of the mind called the amygdala. It is common to see immediate relief from anxiety symptoms with first dosing, but several weeks with daily dosing are needed to see the maximal therapeutic benefit....
Directions for Use of Aculip H Tablets
- This medication should be taken as prescribed by the treating physician.
- Unexpected stoppage of the medication can compel withdrawal side effects.
- Consult your doctor before stopping this medication.
- It is recommended to consume this medication on a regular schedule, i.e., at the same time every day, for optimal pharmacological effects of this medication.
- Swallow this medication as a whole. Do not granulate, break or bite this tablet.
- Inform your doctor regarding other medications you may be taking to review and prevent any medication interaction associated effects.
Interactions of Aculip H Tablets
Interactions with other medicines
- This medication causes prolongation of QTc interval and should not be used in addition to other medicines that also have the same effect. It may result in cardiac arrhythmias and other potentially life-threatening conditions. Examples include astemizole, cisapride, disopyramide, ibutilide, indapamide, pentamidine, pimozide, procainamide, quinidine, sotalol, terfenadine....
- Amitriptyline gets utilised through CYP3A4. A few medications modify the action of CYP3A4. The dose should be mindfully controlled, just as the whole understanding medication routine checked for CYP3A4 inducers and inhibitors....
- It is recommended to discontinue this medication before elective surgery to decrease the risk of interaction with anaesthetic agents.
- This medication should not be used:
- Concomitantly with MAOIs (Monoamine oxidase inhibitors) or within 14 days of the use of MAOIs and vice versa. Examples of MAOIs include Selegiline, rasagiline.
- With other medications known to increase serotonin levels. For example, isocarboxazid, phenelzine, procarbazine, safinamide, selegiline, tranylcypromine, sertraline as it may cause Serotonin syndrome, a potentially fatal condition. ...
- With opioid medications, benzodiazepines, or CNS depressants.
Interactions with food items
- One can have this medicine with or without food
Storage and disposal of Aculip H Tablets
Store under 30’C. Keep out of reach of children and pets. Do not expose to direct sunlight or moisture. Discard the medication after the date of expiration.
Dosage of Aculip H Tablets
Overdose
- Amitriptyline harmfulness is quantifiable by a portion of more than 5 mg/kg. Amitriptyline toxicity can be severe and even lethal., requiring ICU admission and intervention. In the event of overdose, the patient may have sleepiness, seizures, coma, raised heart rate, low blood pressure, irregular heart rate, dilated pupils, dry mouth, decreased (or absent) bowel sounds, inability to pass urine. In case of a suspected overdose, immediately rush the patient to the nearest tertiary hospital....
- In cases of chlordiazepoxide overdose or toxicity, the patient may show signs of confusion, slow reflexes, drowsiness, or coma. This requires immediate intervention, and the patient should be rushed to a hospital immediately....
Missed a Dose
Assuming you miss a dose of this pill, it is advised to be taken at the earliest. If the duration missed is too long, and it is almost time for the next dose, it is recommended to skip the missed dose and go back to the regular schedule. Do not double the dose of the tablet....
Content Details
WRITTEN BY
REVIEWED BY
Dr. Bhavika Shah
MBBS, MD (Dermatology), DNB (Dermatology)
Frequently Asked Questions (FAQs)
Q: This medicine makes me feel dizzy and tired. Does that mean I should stop it?
A: No. While dizziness and drowsiness are known side effects of Aculip H, you should never stop the medication without consulting your doctor. Always inform your prescribing doctor about side effects to adjust the dose as required.
Q: Can I take painkillers while on this medication?
A: It depends upon the contents of the medication you are taking. Always inform your doctor about any medication you take routinely. Painkillers may contain opioids and this can be dangerous.
Q: I only drink socially. Is an occasional drink okay?
A: No. Alcohol slows down brain activity and acts as a depressant. Do not consume alcohol while on this medication.
References
View All
- Thour A, Marwaha R. Amitriptyline. [Updated 2021 Jul 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from
- Ahwazi HH, Abdijadid S. Chlordiazepoxide. [Updated 2020 Nov 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from:
- Levate (Amitriptyline)
Health Articles
Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
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