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Uses of Zonisamide

  • Epilepsy as an adjunct therapy as well as monotherapy
  • Tardive dyskinesia
  • Migraine headaches
  • Bipolar depression

Contraindications of Zonisamide

When should one not use Zonisamide

Allergic to any ingredients of Zonisamide capsule or any other Sulfa medicine.

Side effects of Zonisamide

Common side effects of this drug are:

  • Dizziness
  • Agitation (a state of anxiety or nervous excitement)
  • Irritability (state of being irritable)
  • Memory issues
  • Loss of appetite
  • Allergic reaction (rare)
  • Anxiety (rare)
  • Abdominal pain (rare)
  • Nausea (rare)
  • Fatigue (rare)
  • Weight loss (rare)

Precautions and Warnings of Zonisamide



Can I take Zonisamide during pregnancy?
Do not use this medicine during pregnancy as it may affect the baby.

Breast Feeding

Can I take Zonisamide while breastfeeding?
This medicine passes into breast milk. Hence do not use this medicine during breastfeeding.


Can I drive if I have consumed Zonisamide?
This medicine may lead to cause dizziness or drowsiness. Hence, do not drive.


Can I consume alcohol with Zonisamide?
Alcohol should not be taken along with Zonisamide; it increases drowsiness and dizziness.

Other General Warnings

Talk to your doctor if
  • Less than 12 years or elderly
  • Kidney problems
  • Liver diseases
  • Pressure in the eye (glaucoma)
  • Taking this medicine may lead to make you sweat less which makes you more likely to get a heatstroke

Mode of Action of Zonisamide

How Does It Work?

It is believed that Zonisamide exerts its antiseizure activity by suppression of neurons.

Interactions of Zonisamide

Interactions with other medicines

Carbonic Anhydrase inhibitors like Acetazolamide, Topiramate and Anticholinergics because they increase the risk of high blood acid levels and kidney stone problem might aggravate.

Interactions with food items

No information is available on interactions of Zonisamide when taken with food, consult your doctor or pharmacist for further details.

Dietary Restrictions of Zonisamide

No information is available on interactions of Zonisamide when taken with food, consult your doctor or pharmacist for further details.

Dosage of Zonisamide


Slow breathing, severe dizziness or sometimes loss of consciousness are symptoms of overdose. Inform your doctor immediately in case of overdose.

Missed a Dose

Take the missed dose as early as you remember. Skip the missed dose if it is time for the next dose; do not take extra medicine to compensate for the missed dose.

Content Details


Dr. Mansi Savla

B. Pharm, PharmD


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should be discussed with my healthcare provider before taking this medicine?

A: If the person is on any other medication, the doctor should be informed. Inform your doctor if you are allergic to Aspirin or any other medicines. Information regarding any liver, kidney, heart disease as well as breathing disorders should be shared with your doctor.

Q: What should I know regarding the storage of medication?

A: Zonisamide should be stored in a cool, dry place and away from children.

Q: Is there anything else that I need to know?

A: Please do not stop the medication suddenly as it may aggravate the symptoms of seizures and epilepsy. The dose should be gradually lowered and then discontinued. This should be done at the physician's discretion.

Q: When and how to consume the medicine?

A: Zonisamide is taken with water orally without chewing or breaking. It can be taken with or without food.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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