Tolbutamide

Molecule Description

Tolbutamide is an oral hypoglycemic medicine that is used to control blood suga

r levels in patients of Type 2 Diabetes Mellitus.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Tolbutamide

Type 2 Diabetes Mellitus

Contraindications of Tolbutamide

When should one not use Tolbutamide

Allergic to Tolbutamide
Diabetic ketoacidosis (a complication of diabetes with rapid weight loss, nausea or vomiting)
Diabetic coma
Severe kidney, liver, thyroid or adrenal gland disease
Unusual stressful conditions
Porphyria (a hereditary disorder affecting the liver or bone marrow)

Side effects of Tolbutamide

Common side effects of this drug are:

Sudden sweating
Shaking
Faster heartbeat
Blurred vision
Unsteadiness
Tingling in hands and feet
Dark-colored urine
Easy bruising and bleeding
Abdominal pain
Constipation
Yellow skin or eyes
Disturbances in liver function
Sensitivity to light, skin rashes
Anaemia
Low blood sugar

Precautions and Warnings of Tolbutamide

Pregnancy

Can I take Tolbutamide during pregnancy?

This medicine should not be taken during pregnancy. If you have already planned a pregnancy, you should consult with your doctor.

Breast Feeding

Can I take Tolbutamide while breastfeeding?

It is not recommended in patients who are breastfeeding. It may affect the newborn baby.

Driving

Can I drive if I have consumed Tolbutamide?

It may affect your driving ability if your blood sugar is lowered (hypoglycaemia) or raised (hyperglycaemia) or if you develop visual problems as a result of such conditions. Be cautious if you opt to drive.

Alcohol

Can I consume alcohol with Tolbutamide?

It would help if you strictly restricted drinking alcohol when taking this medicine as it may cause severe reactions.

Other General Warnings

Talk to your doctor if

Be very careful about symptoms of low blood sugar like sweating, anxiety, fast heartbeat, headache, intense hunger, restlessness, dizziness, irritability. If you experience these symptoms, immediately...
Read more
Eat something as soon as possible. If the symptoms persist even after this, seek emergency medical help
Tell your doctor if:
You have liver or kidney disease
Your body is not able to produce enough red blood cells
All your ongoing medications

Mode of Action of Tolbutamide

How Does It Work?

It acts on the cells of the pancreas and increases the release of insulin, thereby controlling the levels of blood glucose.

Interactions of Tolbutamide

Interactions with other medicines

Antifungal medicines (e.g. Fluconazole)
Allopurinol and Sulfinpyrazone (used in the treatment of gout)
Hormonal contraceptive pills
High blood pressure medicines (e.g., Propranolol, Atenolol), ACE inhibitors (e.g. Captopril) and Fibrates (e.g. Clofibrate)
Adrenaline (Epinephrine)
Antibiotics such as Chloramphenicol, Rifampicin, Fluoroquinolones, Tetracyclines or Sulphonamides such as Sulfafurazole and Cotrimoxazole
Cimetidine and Ranitidine (used for stomach ulcers)
Medicines used to prevent blood clotting

Interactions with food items

Interaction with alcoholic beverages is reported.

Dietary Restrictions of Tolbutamide

Avoid foods with a high glycemic index (white rice, ice-cream, french fries, mangoes). It is advisable to follow a strict diabetic diet.

Dosage of Tolbutamide

Overdose

Overdose of this medicine may cause low sugar levels (symptoms may include sweating, paleness, headache, faintness or drowsiness). Therefore you should instantly consume sugar (e.g. sugar cubes, sweet...

Missed a Dose

If you forget to take medicine, follow the regular dose schedule instead of taking a double dose.

Content Details

WRITTEN BY

Dr. Arpit Verma

MBBS, MD (Pharmacology)

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: How does this medication reduce my sugar levels?

A: Tolbutamide increases the amount of insulin released by your pancreas and thus reduces your blood sugar levels.

Q: Can elderly patients take this medication?

A: Yes, but it should be initiated at lower doses and must be used with caution. Take as prescribed by the doctor.

Q: Should I be worried while on the medication of Tolbutamide?

A: If you experience any symptoms of dizziness, fainting, sweating and tremors, it may be due to hypoglycaemia. Drink some glucose water, juice or eat sugar or chocolates, then report to the doctor. A regular follow up with your physician is essential.

References

Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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