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Molecule Description

Tobramycin is used to treat the infections caused by bacteria.

Uses of Tobramycin

  • Used to treat bacterial infection of the skin, heart, stomach, brain, spinal cord, lungs and urinary tract
  • Used to treat Infection in eye
  • Used in the treatment of cystic fibrosis

Contraindications of Tobramycin

When should one not use Tobramycin

  • Do not take this medicine if you are allergic to this medicine ingredient
  • Taking with Ethacrynic Acid, Furosemide, Mannitol or Urea
  • Taking the medicines that may damage your kidney

Side effects of Tobramycin

Common side effects of this drug are:

  • Black, tarry stools
  • Chest pain
  • Chills
  • Tinnitus (continuous ringing or buzzing noise in the ear)
  • Painful or difficult urination
  • Tiredness
  • Diarrhea
  • Headache
  • Weakness
  • Shortness of breath
  • Sore throat; sores, ulcers or white spots on lips or in the mouth
  • Swollen glands
  • Hearing loss
  • Unusual bleeding or bruising

Precautions and Warnings of Tobramycin


Can I take Tobramycin during pregnancy?
Do not continue the medication of Tobramycin if you are pregnant or planning a pregnancy.

Breast Feeding

Can I take Tobramycin while breastfeeding?
Tobramycin is poorly excreted into breastmilk; do not breastfeed while taking this medicine.


Can I drive if I have consumed Tobramycin?
Do not drive unless you feel well.


Can I consume alcohol with Tobramycin?
Avoid drinking alcohol with Tobramycin because it may increase the risk of the medicine's side effects.

Other General Warnings

Talk to your doctor if
  • Hearing problems (noises in the ears and dizziness)
  • Kidney problems
  • Difficulty in breathing with wheezing or coughing
  • Chest tightness
  • Blood in your sputum (the substance you cough up)
  • Muscle weakness that lasts or becomes worse over time, a symptom mostly related to conditions like myasthenia or Parkinson’s disease

Mode of Action of Tobramycin

How Does It Work?

Tobramycin works by inhibiting protein synthesis. It does this by irreversibly binding to bacterial 30S and 50S ribosomes present in the bacteria and prevents the multiplication and growth of bacteria.
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Interactions of Tobramycin

Interactions with other medicines

  • Some of the medicines which may interact with Tobramycin:
  • Cephaloridine, Cephalosporins (such as Ceftizoxime), Cisplatin, Colistin, Cyclosporine, Fludarabine, loop diuretics (such as Furosemide, Ethacrynic Acid), Methoxyflurane, Nitrosoureas (such as Carmustine), NSAIDs (such as Ibuprofen), Polymyxin B, Vancomycin or Viomycin, nondepolarizing muscle relaxants (e.g. Atracurium) or Succinylcholine, etc. may increase the risk of Tobramycin side effects such as increased risk of kidney damage or hearing loss
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  • Beta-lactam antibiotics such as Penicillin, Imipenem, Sultamicillin may decrease Tobramycin effectiveness

Interactions with food items

No food interaction reported with Tobramycin.

Dosage of Tobramycin


Overdose of Tobramycin include symptoms such as dizziness, ringing in the ears, difficulty in breathing or decreased breathing, loss of hearing and weakness. Inform your doctor immediately in case of overdose.
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Missed a Dose

If you have missed the regular Tobramycin dose, then take the missed dose as soon as you remember it. If it is almost time for next dose then skip the missed dose. Do not take a double dose and consult your doctor for further treatment.
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Content Details


Dr. Abhishek B L

MBBS, MD (Pharmacology)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I tell your doctor before starting the treatment with this medicine?

A: Tell your doctor if you have myasthenia gravis or Parkinson’s disease, hearing problem, nerve problem, kidney problem, extensive burns or dehydrated condition.

Q: What precaution should I take?

A: Use this medicine with caution in children, elderly and patients with kidney or hearing problems.

Q: When and how to consume the medicine?

A: Take Tobramycin injection at your doctor’s hospital or clinic. If you feel any unusual effects after injection, consult your doctor. If you are not admitted in the hospital, you must follow the appointment schedule rigorously.

Q: Can this medicine be given in children?

A: Tobramycin should not be given to children who are less than ten years old.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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