Tibolone

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Molecule Description

Tibolone is a synthetic steroid medicine used for Hormone Replacement Therapy (HRT). It mimics the activity of the female sex hormones estrogen and progesterone and the androgen testosterone in the body.

Uses

This medicine is used to relieve the symptoms of estrogen deficiency (hot flushes, depression, decreased sex drive), in women who have gone through the menopause. It is also used to prevent osteoporosis in women who have gone through the menopause.

Contraindications

When should one not use Tibolone

Women with any history of blood clotting (arterial thromboembolic) disease including stroke, transient ischemic attack, myocardial infarction and angina, breast cancer
Allergic to this medicine
History of liver disease with abnormal liver enzymes
Any vaginal bleeding
Any blood clots in the lungs, veins
History of any inherited blood disorders (porphyrias)

Side effects

Common side effects of this drug are:

Vaginal bleeding or spotting
Vaginal discharge
Vaginal thrush
Vaginal itching
Breast tenderness
Abnormal hair growth
Weight gain
Thickening of the inner lining of the uterus (called the endometrium)

Precautions and Warnings

Pregnancy

Tibolone is not recommended to use during pregnancy. It is not indicated in women who have not yet undergone menopause. Stop this medication immediately if you think you are pregnant and inform your physician.

Breast Feeding

It is not recommended during breastfeeding. Consult with your doctor if you are taking this medicine while breastfeeding.

Driving

No influence on ability to drive.

Alcohol

Alcohol consumption with this medicine causes an increase in the risk of breast cancer. Avoid alcohol while on this treatment.

Other General Warnings

Talk to your doctor if

History of excessive thickening of uterus (endometriosis)
If you have a history of elevated blood pressure, diabetes, gallstones, migraine headaches, asthma
You have had any history of breast cancer
If you experience any swelling, pain in legs, sudden pain in the chest, blood clots after taking this medicine; stop the treatment immediately and inform your doctor.

Mode of Action

How Does It Work?

It acts similarly to the natural estrogen, progesterone and testosterone found in the body. This helps restore the balance of hormones in the body and reduces the symptoms of menopause, whether natural or otherwise.

Interactions

Interactions with other medicines

Medicine used to treat tuberculosis (Rifampicin)
Blood thinners (Warfarin)
Medicines used to treat epilepsy (Phenobarbital)

Interactions with food items

It may interact with can broccoli, red wine, cabbage, brussels sprouts, red wine, alcohol, grapefruit juice and cigarette smoke.

Dietary Restrictions

No information is available on dietary restrictions while you are taking Tibolone, consult your doctor or pharmacist for further information.

Dosage

Overdose

Seek emergency medical help if you think you have taken too much dose of this medicine. Symptoms of overdose include nausea, vomiting and vaginal bleeding in females may occur.

Missed a Dose

If you missed any doses of medicine, take it as soon as you remember. Skip the missed dose if it is time for your subsequent scheduled dose. Do not take extra medicine of medicine to make up the missed dose.

Frequently Asked Questions (FAQs)

You should not use this medicine if you are allergic to it, tell the list of medications you are using and discuss your health condition with your doctor before taking medicine.

This medicine may be taken with or without food with a glass of water. It should be taken at the same time each day.

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