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Molecule Description

Teneligliptin is a medicine given to control raised blood sugar levels in patients with Type 2 diabetes. It belongs to a class of anti-diabetic medicines called ‘DPP-4 inhibitors’ or ‘Gliptins.’

Uses of Teneligliptin

Type 2 Diabetes, along with changes in diet and exercise.

Contraindications of Teneligliptin

When should one not use Teneligliptin

  • Allergy to Teneligliptin or any other ingredients of the medicine
  • Severe diabetic ketoacidosis, diabetic coma
  • Type 1 diabetes
  • Serious infections, severe trauma or significant surgeries (in these situations, sugar control has to be done by insulin alone)

Side effects of Teneligliptin

Common side effects of this drug are:

  • Hypoglycemia (low blood sugar)
  • Constipation
  • Gastrointestinal symptoms (abdominal discomfort, ulcers, polyps (overgrowths), nausea, diarrhea, damage of oesophageal lining)
  • Fatigue
  • Kidney problems (high protein in urine)
  • Skin rashes, itching, redness (allergic reactions)
  • Increased liver function tests, CPK levels, serum potassium, uric acid levels

Precautions and Warnings of Teneligliptin


Can I take Teneligliptin during pregnancy?
This medicine is not recommended during pregnancy unless there is no alternative. Inform your doctor immediately if you plan or detect pregnancy.

Breast Feeding

Can I take Teneligliptin while breastfeeding?
Teneligliptin is not recommended while breastfeeding as the medicine can be secreted in breast milk and can harm the baby.


Can I drive if I have consumed Teneligliptin?
If your blood sugar is low or high, it may affect your ability to drive.


Can I consume alcohol with Teneligliptin?
Avoid alcohol with this medicine as alcohol intensifies drowsiness and other side-effects.

Other General Warnings

Talk to your doctor if
  • You have advanced liver disease
  • You have heart failure (decreased pumping efficiency of the heart)
  • You have pituitary insufficiency (less than regular levels of pituitary hormones – growth hormone, FSH, LH, ACTH, thyroid hormones, etc.)
  • You have adrenal insufficiency (failure to produce consistent levels of cortisol hormone)
  • You have weakness, irregular diet habits, starvation, strenuous exercise
  • You have a history of any stomach surgery
  • You have heart rhythm abnormalities (arrhythmia, slow heartbeat, serum potassium disturbances)
  • You are using any other medicines that increase insulin secretion (e.g. Sulfonylureas)

Mode of Action of Teneligliptin

How Does It Work?

Teneligliptin works by blocking an enzyme (DPP-4; dipeptidyl Peptidase 4) that degrades insulin, thereby increasing insulin levels in the body and decreasing glucagon levels (hormone with opposing function to insulin which increases glucose levels). This combined effect results in effective control of Type 2 diabetes.
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Interactions of Teneligliptin

Interactions with other medicines

  • Beta-blockers (Metaprolol, Carvidilol, Propanolol, Atenolol, etc.)
  • MAO (Monoamine Oxidase) inhibitors (Selegiline, Rasagiline, Isocarboxazid, Phenelzine, etc.)
  • Levo-Thyroxine
  • Ketoconazole
  • Increased risk of fall in sugar levels when used in combination with Sulfonylureas or Insulin

Interactions with food items

Teneligliptin can be taken without regard to food – before or after meals.

Dietary Restrictions of Teneligliptin

It is advisable to follow a strict diabetic diet and exercise regimen to improve overall control of the disease further.

Dosage of Teneligliptin


Occasional overdose may not be life-threatening unless you have any other complications (heart disease, kidney disease, etc.). In any case, inform your doctor immediately in case of overdose.

Missed a Dose

Take the missed dose as soon as you remember. Skip the missed dose if your next dose is due in a few hours. Do not take extra medicine to compensate for the missed dose.

Content Details


Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking this medicine?

A: Tell your doctor if you drink alcohol and have a history of diabetic ketoacidosis (a serious condition that may occur when blood sugar is too high), pancreatitis (infection of the pancreas), stones in the gall bladder, high blood cholesterol or kidney disease.

Q: Can I take Insulin along with Teneligliptin?

  • Sometimes, when it is difficult to control blood sugars within required levels, your doctor may prescribe an additional dose of insulin, though you may not be required to take it at the same time with Teneligliptin
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  • But, self-medication and self-adjusting the dosage is strictly not recommended and this medicine should only be used when prescribed by a doctor.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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