Rasagiline

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Molecule Description

Rasagiline is used to treat Parkinson’s disease (nervous system disorder that affects movement).

Uses

To treat the symptoms of Parkinson’s disease (stiffness/ rigidity, tremors, spasms, poor muscle control) as initial monotherapy and as an addition to Levodopa.

Contraindications

When should one not use Rasagiline

Do not take this medicine if you are allergic to it or have a severe liver problem.

Side effects

Common side effects of this drug are:

Involuntary movements (dyskinesia)
Headache
Hallucinations (the sight of those objects or people who do not exist in reality), fever, restlessness, tremor and sweating
Constipation, diarrhea, excessive sleepiness, dry mouth
Headache, joint pain, mild stomach pain
Loss of appetite, weight loss
Urinary urgency
Irritation of the skin (dermatitis)
Depression
Runny nose (rhinitis), irritation of the skin (dermatitis)
Rash, bloodshot eyes (conjunctivitis)

Precautions and Warnings

Pregnancy

The effect of Rasagiline on the fetus is not known, consult your doctor if you are pregnant, your doctor will tell you on the use of this medicine after assessing the benefits over risks.

Breast Feeding

Tell your doctor if you are breastfeeding, as no information is available on the use of Rasagiline if you are breastfeeding. Your doctor will tell you about the use of this medicine after assessing the benefits over risks.

Driving

It is not advised to drive any vehicle or use heavy machinery when on this medication.

Alcohol

It is not advised to consume alcohol.

Other General Warnings

Talk to your doctor if

You have liver problems
You notice any changes in your skin while on medication of Rasagiline
Your family and friends notice any changes in your mood and behaviour like compulsions, obsessive thoughts, addictive gambling, excessive spending, impulsive behaviour and an abnormally high sex drive

Mode of Action

How Does It Work?

In patients of Parkinson’s disease, there is a reduction in the levels of certain chemical neurotransmitters which affect the movement of the body. Rasagiline works by increasing the level of these chemicals in the brain.

Interactions

Interactions with other medicines

Antidepressants
Antibiotic like Ciprofloxacin
Cough suppressant like Dextromethorphan
Nasal and oral decongestants and cold medicine like Ephedrine or Pseudoephedrine

Interactions with food items

Avoid tyramine containing products like aged cheese, aged, dried, fermented, salted, smoked, pickled and processed meats and fish, concentrated yeast extracts, packaged soups
Do not take caffeine, chocolates, coffee or cola with this medicine

Dietary Restrictions

Avoid the following tyramine containing products-
Aged cheese
Packaged soups
Caffeine
Chocolates
Coffee
Cola

Dosage

Overdose

If you overdose with Rasagiline, immediately call your doctor or visit the nearest hospital. Signs and symptoms of Rasagiline overdose may include brain-related issues like sleepiness, unsteadiness, fainting, irritability, hyperactivity, agitation, severe headache, hallucinations, lock-jaw, unconsciousness and coma. Heart-related issues may include rapid and irregular pulse, changes in blood pressure and blood vessel collapse, chest pain, trouble in breathing, cold, clammy skin.

Missed a Dose

Take the missed dose as early as you remember. Skip the missed dose if it is too late. Do not take extra medicine to compensate for the missed dose.

Frequently Asked Questions (FAQs)

Give a detailed account of your medical and surgical history. Also, notify your doctor about all the prescription and non-prescription medicines, herbal preparations and nutritional supplements that you may be taking before starting this medication.

Use Rasagiline with caution if you have high blood pressure because it may worsen the conditionAvoid the following tyramine containing products-Aged cheeseAged, dried, fermented, salted, smoked, pickled and processed meats and fishCommercial graviesConcentrated yeast extractsPackaged soupsDo not take caffeine, chocolates, coffee or cola with this medicine

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