Ramipril
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Regulated
Molecule Description
Ramipril belongs to a class of medications called Angiotensin-Converting Enzyme (ACE) inhibitors. Ramipril is used in high blood pressure. It helps to reduce the risk of stroke and heart attack.
Uses
- Chronic congestive heart failure (CCF)
- After a heart attack (Myocardial Infarction)
- High blood pressure
- Diabetic kidney disease
Contraindications
When should one not use Ramipril
- Are allergic to Ramipril
- Ever had angioedema (itching hives, swelling of face, tongue, throat, difficulty breathing)
- Have a condition called renal artery stenosis where blood supply to the kidney is hampered
- Too low blood pressure
- Pregnancy
Side effects
Common side effects of this drug are:
- Cough, low blood pressure, headache and dizziness
- Fainting
- Skin rash
- Cramps in legs
- Increase potassium in blood test
- Nausea, vomiting, and diarrhea are also seen
- Abnormal kidney function
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- If you have heart, liver or kidney problems
- If you have high amounts of potassium in your blood (shown in blood test results)
- If decreased sodium levels in your blood
- If you have collagen vascular diseases such as scleroderma or systemic lupus erythematosus
Mode of Action
How Does It Work?
Angiotensin-Converting Enzyme (ACE) helps in forming angiotensin, which causes spasm or tightening of healthy blood vessels. ACE-inhibitors like Ramipril work by decreasing angiotensin, thus smooth the blood flow, so that the heart can pump blood more efficiently. It also lowers the blood pressure.
Interactions
Interactions with other medicines
- All angiotensin receptor blockers e.g. Valsartan
- Pregabalin
- Aspirin
- Azathioprine
- When taken along with Ramipril these are known to increase serum potassium in your blood such as Spironolactone, Triamterene, Amiloride, potassium salts, Trimethoprim alone or in combination with Sulfamethoxazole (for infections) and Heparin (for blood thinning)
Interactions with food items
- No known interaction with food.
Dietary Restrictions
Avoid foods containing high potassium content. Low-salt diet preferred.
Dosage
Overdose
There can be different signs of Ramipril overdose but typically it can include extreme low blood pressure, increased levels of sodium or potassium in the blood, sudden kidney failure. Seek for medical help if you suspect an overdose of medicine.
Missed a Dose
If you missed any dose, take it as soon as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to compensate for a missed one.
Frequently Asked Questions (FAQs)
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