Prochlorperazine
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Molecule Description
Prochlorperazine is a medicine commonly used to relieve nausea, vomiting, and dizziness, including those caused by migraines or after surgery. It works by blocking certain chemical signals in the brain, especially dopamine, that trigger nausea, helping you feel more stable and comfortable. This medicine can also help with vertigo and balance-related problems. Always use it exactly as advised by your doctor and inform them about any existing health conditions or other medicines you are taking to ensure safe and effective treatment.
Uses
- Prochlorperazine is used for the treatment of nausea, vomiting, post operative vomiting & migraine induced vomiting.
Contraindications
When should one not use Prochlorperazine
If you are allergic to prochlorperazine
Side effects
Common side effects of this drug are:
- Drowsiness
- Dizziness
- Amenorrhea
- Blurred vision
- Skin rash
- Dry mouth
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have heart problems or a history of heart disorders.
- You have thyroid, liver, or kidney problems.
- You have a tumor of the adrenal glands or a prostate problem.
- You have fits or are suffering from Parkinson's disease.
- You have low blood levels of calcium, potassium, and magnesium.
- You have a history of alcohol consumption.
- You have a stroke, low mood, blood clot disorder, diabetes, etc.
- You are an elderly patient. Prochlorperazine may increase sensitivity to sunlight.
- You should avoid exposure to direct sunlight while taking this medicine.
Mode of Action
How Does It Work?
Prochlorperazine works by blocking the action of dopamine receptors in the brain, which is responsible for causing nausea and vomiting.
Interactions
Interactions with other medicines
- Some medicines can affect the way Prochlorperazine works, or Prochlorperazine itself can reduce the effectiveness of other medicines taken at the same time.
- Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.
- Especially if you are taking medicines to treat high blood pressure, heart failure, high/abnormal cholesterol levels, blood thinners, anti-infectives, anti-diabetics, anti-asthmatics, pain killers, antiparkinson, immunomodulatory medicines or medicines for the brain-related disorder.
- Medicines used for irritable bowel syndrome, asthma (anticholinergic medicines) may reduce the effectivity leading to constipation or heart stroke.
Dosage
Overdose
- If you take more Prochlorperazine than you should, immediately contact your doctor as taking too much. Prochlorperazine may cause symptoms such as feeling sleepy or dizzy, increased or rapid heartbeat, feeling very cold and confused, feeling restless, stiffness or shaking. You may lose consciousness.
Missed a Dose
If you missed any dose of medicine, take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dose schedule. Do not take a double dose of medicine to compensate for the missed one.
Frequently Asked Questions (FAQs)
Articles
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References:
- Prochlorperazine 5 mg tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [cited 27 August 2021]
- Prochlorperazine [Internet]. Cdscoonline.gov.in. 2021 [cited 27 August 2021]
- DailyMed - PROCHLORPERAZINE MALEATE tabletPROCHLORPERAZINE MALEATE tablet [Internet]. Dailymed.nlm.nih.gov. 2021 [cited 27 August 2021]
- Prochlorperazine [Internet]. Ncbi.nlm.nih.gov. 2021 [cited 27 August 2021]
- Drugbank.Prochlorperazine.Drugbank[cited 13 Mar 2025].
- Din L, Preuss CV. Prochlorperazine. [Updated 2023 Aug 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing;[cited 13 Mar 2025].
- Prochlorperazine Edisylate Injection, USP. Prescribing Information. March 2010.[cited 13 Mar 2025].
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