Prasugrel+Aspirin / Acetyl Salicylic Acid

When should one not use Prasugrel+Aspirin / Acetyl Salicylic Acid

• If you are allergic to prasugrel, aspirin or any other ingredients of Prasugrel+Aspirin / Acetyl Salicylic Acid.
• If you have had asthma, breathing problems, or allergic reactions to them.
• If you have or had stomach ulcers, bleeding in your stomach, brain, or other areas, or a bleeding disorder like haemophilia or low platelets, especially if you are on blood thinners.
• If you have severe liver or kidney problems.
• If you have gout or a history of stroke or mini-stroke (TIA).
• If you are under 16 years old (unless prescribed for specific conditions like Kawasaki disease).
• If you are pregnant in the last trimester and taking more than 100 mg of aspirin daily, or taking high-dose methotrexate.

Common side effects of this drug are:

• Indigestion
• Increased tendency for bleeding
• Bleeding in the stomach or bowels
• Bleeding from a needle puncture site
• Nose bleeds
• Skin rash
• Small red bruises on the skin (ecchymoses)
• Blood in urine

Other General Warnings

• If you are asthmatic, have hay fever, nasal polyps, or other chronic respiratory conditions, aspirin may trigger an asthma attack.
• If you have other kidney, liver, or heart problems.
• If you have high blood pressure (your doctor may want to monitor you closely), or if you are dehydrated.
• If you have a condition called glucose-6-phosphate dehydrogenase deficiency.
• If you are elderly (your doctor may want to monitor you closely).
• If you have or have ever had issues with your stomach or small intestine.
• If you experience heavy menstrual periods, you should seek medical advice immediately.
• Seek medical help immediately if your symptoms worsen or if you experience severe or unexpected side effects, such as unusual bleeding, serious skin reactions, or any other signs of serious allergy.

How Does It Work?

• Prasugrel works by helping to prevent blood clots. It does this by stopping certain cells in your blood, called platelets, from sticking together. When platelets clump together, they can form clots that block blood flow, which can lead to heart attacks or strokes. By making platelets less sticky, prasugrel helps keep your blood flowing smoothly, especially after procedures such as placing a stent in your heart.
• Aspirin works by stopping the action of a substance in your body that helps form blood clots and causes pain and swelling. It reduces the stickiness of platelets, which are tiny blood cells that help stop bleeding, thereby making your blood less likely to clot. This helps prevent heart attacks and strokes in people at risk.

Interactions with other medicines

• Avoid taking aspirin with high-dose methotrexate, certain gout medications (like probenecid), or multiple painkillers like ibuprofen, as these combinations can increase side effects or reduce effectiveness.
• Using aspirin with blood thinners (like warfarin or heparin), anti-platelet drugs (like clopidogrel), or antidepressants (like SSRIs) increases the risk of bleeding.
• Aspirin can interact with medicines for diabetes, heart conditions (like digoxin), and mood disorders (like valproate or phenytoin), so doses may need adjusting or monitoring.
• Alcohol, steroids, and anti-seizure drugs can increase aspirin's side effects, especially related to the stomach or bleeding.
• Prasugrel increases bleeding risk when taken with blood thinners, NSAIDs, or morphine, but is generally safe to use with aspirin, statins, acid-reducing medicines, and some heart medications.

Overdose

Missed a Dose