Nortriptyline+Vitamin B12 / Mecobalamin / Cynocobalamin / Methylcobalamin+Pregabalin

Uses	Neuropathic Pain
Therapy	Drugs For Peripheral Neuropathy
Side Effects	Sleepiness, Dizziness

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NPPA
Regulated

Molecule Description

Pregabalin+Nortriptyline+Methylcobalamin is a combination medicine. It is used in the treatment of neuropathic pain. Neuropathic pain is a condition of an abnormal painful sensation in different body parts due to damage in a part of the brain responsible for sensing external stimuli. Pregabalin+Nortriptyline+Methylcobalamin is available in the form of a tablet. Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding and about all the medicines and supplements you take and all the conditions or diseases you suffer from, before starting this medicine.

Uses

Pregabalin+Nortriptyline+Methylcobalamin is used for the treatment of neuropathic pain.

Contraindications

When should one not use Nortriptyline+Vitamin B12 / Mecobalamin / Cynocobalamin / Methylcobalamin+Pregabalin

If you are allergic to pregabalin, nortriptyline or methylcobalamin
If you are taking certain medicines (MAO Inhibitors) to treat psychiatric illnesses or adrenaline like medicines
If you are suffering from mania

Side effects

Common side effects of this drug are:

Nausea
Vomiting
Dizziness
Sleepiness
Weakness

Precautions and Warnings

Pregnancy

Consult your doctor before using pregabalin+nortriptyline+methylcobalamin during pregnancy as limited safety data is available in pregnant women. Use effective contraception during treatment.

Breast Feeding

Consult your doctor before using pregabalin+nortriptyline+methylcobalamin while breastfeeding as limited study has been done on its safety.

Driving

Avoid driving if you feel dizzy or drowsy after taking pregabalin+nortriptyline+methylcobalamin.

Alcohol

Avoid consuming alcohol with pregabalin+nortriptyline+methylcobalamin, as it may worsen the side effects.

Other General Warnings

Talk to your doctor if

You have problems with your heart, liver, kidneys
You have diabetes or thyroid problems
You have a history of fits
You have high pressure in the eyes (glaucoma)
You have an enlarged prostate
You are experiencing muscle weakness, pain, discomfort, tenderness
You have difficulty in breathing or any other respiratory illness
You notice changes in mood and behaviour, feel agitated and overactive or are having suicidal thoughts after taking this medicine, talk to your doctor immediately.
You are experiencing dizziness, sleepiness or vision problems.
You develop allergies like bumps and swelling in the skin, itching, difficulty in breathing after taking this medicine.
You experience any abnormal symptoms after taking this medicine
You are scheduled for any surgery or dental procedure involving local or general anaesthesia
You are pregnant or breastfeeding
You are above 65 years of age
You consume alcohol regularly
This medicine can make you sensitive to sun, thus wear full clothes and apply sunscreen when stepping into bright sunlight

Mode of Action

How Does It Work?

Pregabalin works by reducing the release of a chemical (neurotransmitter) in the brain responsible for the sensation of pain.
Methylcobalamin (Vitamin B12) helps in the formation of nerve cells and regeneration of damaged nerves.
Nortriptyline helps in enhancing mood by increasing chemical messenger in the brain.
Hence it relieves neuropathic pain.

Interactions

Interactions with other medicines

Some medicines can affect the way pregabalin+nortriptyline+methylcobalamin works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.
If you are taking medication to treat diabetes, psychiatric illnesses, blood pressure, Parkinson's disease, heart problems, infections or are taking antibiotics.