Nicorandil

Uses	Angina or chest pain
Therapy	Anti-Anginal
Side Effects	Headache, dizziness, nausea, vomiting, skin redness, weakness

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Molecule Description

Nicorandil is a medication prescribed to prevent and treat angina, a type of heart-related chest pain. It's usually used when other heart medications aren't suitable or haven't been effective. This medicine works by widening blood vessels, improving blood flow to the heart, and reducing the chance of an angina attack. You can take Nicorandil with or without food. Take the medicine with water. For best results, take it regularly and at about the same time each day. Your doctor will decide your dose and how often you should take it, which may be adjusted based on how you respond to the medication. It's important not to stop taking this medicine suddenly without talking to your doctor, as doing so may cause your chest pain to return. To further support your heart health, you can make lifestyle changes such as quitting smoking, reducing alcohol intake, eating healthily, exercising regularly, and managing stress. The most common side effect is a headache, especially during the first few days. This usually improves within a week. Staying well-hydrated and avoiding alcohol can help. Other common side effects include dizziness, weakness, nausea, and flushing (a feeling of warmth in your face, ears, neck, and chest). If these side effects bother you or don't go away, talk to your doctor. Nicorandil might not be suitable for everyone. Make sure to tell your doctor if you have a history of low blood pressure or heart failure. It's also important to inform your doctor about all other medications you are taking, as some may interact with this medicine. You should not take any medicines for erectile dysfunction while using this medication. Nicorandil is generally not recommended during pregnancy or breastfeeding.

Uses

Nicorandil is used for the prevention and long-term treatment of heart-related chest pain.

Contraindications

When should one not use Nicorandil

If you are allergic to Nicorandil or any other components of this medicine
If you have a low blood pressure
If your doctor has told you that you have certain serious heart problems (such as cardiogenic shock)
If your doctor has told you that you have a build-up of fluid in your lung
If you are taking medications like vardenafil, sildenafil, etc. to treat impotency or riociguat to treat a lung disease

Side effects

Common side effects of this drug are:

Headache
Dizziness
Nausea
Vomiting
Skin redness
Weakness

Precautions and Warnings

Pregnancy

It would be preferable if you could avoid using Nicorandil during pregnancy as there is limited information about its safety. Please consult your doctor before using any medicine during pregnancy.

Breast Feeding

Nicorandil is not recommended during breastfeeding because it is unknown if it passes into breast milk. Please consult your doctor before using any medicine while breastfeeding.

Driving

Nicorandil may cause dizziness or blurred vision as side effects, thus, you need to be cautious while driving or operating machines.

Alcohol

Avoid consuming alcohol while on treatment with Nicorandil as it is unsafe and may lower your blood pressure.

Other General Warnings

Talk to your doctor if

You have low blood pressure.
You are suffering from a heart condition.
You have problems with your kidney.
You have a blood enzyme deficiency (glucose-6-phosphate dehydrogenase deficiency).
You have a low blood potassium level and are on medications for it.
You notice red, itchy, swollen eyes, experience mouth ulcers, blood in your stools or vomit, etc., after taking Nicorandil.
Nicorandil is not recommended for use in children.

Mode of Action

How Does It Work?

Nicorandil works by improving the blood and oxygen supply of the heart muscle and reducing its workload, thus increasing the blood flow through the blood vessels of the heart.

Interactions

Interactions with food items

Nicorandil may be taken with or without food.

Dosage

Overdose

Overdose of Nicorandil may lead to a fall in blood pressure (symptoms include dizziness, nausea, unconsciousness, blurred vision, etc) and fast heart rate. Contact your doctor immediately or visit the nearest hospital if you experience any of the symptoms, or think you have taken too much of Nicorandil.

Missed a Dose

In case you've missed any dose of Nicorandil, take it as soon as you remember it. If it is almost time for the next dose, then skip the missed dose. Avoid taking a double dose to compensate for the missed dose.

Frequently Asked Questions (FAQs)

Take it with a glass of water, with or without food or as directed by the doctor. Take it exactly as prescribed by your doctor.

You should avoid taking Nicorandil as there is limited information about its safety for use in pregnant women. Consult your doctor before using any medicine during pregnancy.

You may experience side effects like headache, dizziness, nausea, vomiting, skin redness, weakness, fast or irregular heartbeats.

Nicorandil should be taken as instructed by the doctor. It can either be taken with or without food.

No, Nicorandil is not recommended for use in children as there is limited information about its safety.

Nicorandil is a medicine used to prevent and treat angina (heart-related chest pain). It acts by improving the blood and oxygen supply to the heart muscle, thus reducing chest pain or angina.

No, Nicorandil is not a blood thinner. It acts as a potassium channel activator and relaxes or widens the blood vessels to ensure proper blood and oxygen supply within the blood vessels.

No, you should never stop taking Nicorandil. Abrupt stopping of this medicine may result in angina attack (sudden chest pain) and other conditions resulting in heart attack and difficulty in breathing. Your doctor will gradually reduce the dose of the medicine before stopping the medicine completely. Talk to your doctor for more advice.

Nicorandil works by improving the blood and oxygen supply of the heart muscle and reducing its workload, thus increasing the blood flow through the blood vessels of the heart.

Nicorandil is used for the prevention and long-term treatment of heart-related chest pain. It should be taken in dose and duration as prescribed.

Nicorandil composition includes nicorandil as an active ingredient.

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References:

National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 47528, Nicorandil. Retrieved January 1, 2025

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