Mefenamic Acid+Paracetamol / Acetaminophen

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NPPA
Regulated

Molecule Description

Mefenamic Acid+Paracetamol is a combination medicine. It is used to provide symptomatic relief from mild-to-moderate pain such as pain associated with muscles and joints, headache, migraine and toothache. It also relieves pain due to sports injury, sprain and strain. Mefenamic Acid+Paracetamol is available in the form of tablet, syrup, suspension, oral liquid. Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding and about all the medicines and supplements you take and all the conditions or diseases you suffer from, before starting mefenamic acid+paracetamol.

Uses

Mefenamic Acid+Paracetamol is used to relieve mild to moderate pain such as headache, migraine, toothache, muscle ache, backache, traumatic pain, pain due to sprain and strain and pain after surgeries and operations.

Contraindications

When should one not use Mefenamic Acid+Paracetamol / Acetaminophen

If you are allergic to mefenamic acid, paracetamol or similar medicines
If you have asthma or have had an asthmatic attack due to painkillers
If you are suffering from inflammation in the digestive tract
If you had or have stomach ulcers
It should not be used in the last trimester of pregnancy
It should not be used for managing pain before, during and after coronary bypass surgery

Side effects

Common side effects of this drug are:

Diarrhoea
Drowsiness
Nausea
Vomiting
Stomach pain
Indigestion
Skin rash

Precautions and Warnings

Pregnancy

Mefenamic acid+Paracetamol should not be used during pregnancy or if you are planning to conceive, consult your doctor before using it.

Breast Feeding

Mefenamic acid+Paracetamol can be taken while breastfeeding, if prescribed by the doctor.

Driving

Mefenamic acid+Paracetamol may cause drowsiness, thus you need to be cautious while driving.

Alcohol

Avoid consuming alcohol with mefenamic acid+paracetamol, as it may worsen the side effects.

Other General Warnings

Talk to your doctor if

You have problems with your liver or kidneys
You have a heart condition like stroke, heart failure or myocardial infarction
You have high blood pressure
You have a history of asthma or allergic reactions
You have ulcer in your stomach or intestine or perforations in digestive tract
You have fluid retention in your body

Mode of Action

How Does It Work?

Mefenamic acid+Paracetamol work by blocking the production of a chemical substance (prostaglandin) responsible for pain, inflammation and swelling

Interactions

Interactions with other medicines

Some medicines can affect the way mefenamic acid+paracetamol works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
Especially if you are taking medicines to treat your heart problems, diabetes, infections, nausea or vomiting or are taking medicines like blood thinners, water pills, cholesterol-lowering medicines, antibiotics, steroids, painkillers, medicines used to modify immune system during organ transplant.
Cholesterol-lowering medicines like Colestyramine should be taken with a minimum gap of 2 hours.
This combination should not be taken for 8 to 12 days after taking a medicine called Mifepristone.
Digoxin used to treat heart failure should not be taken along with this combination.

Dosage

Overdose

Symptoms of overdose may include nausea, vomiting, stomach pain, headache, drowsiness. Seek urgent medical help if you suspect an overdose.

Missed a Dose

If you have missed any dose of mefenamic acid+paracetamol then take it as soon as you remember. If it is already time for the next dose then skip the missed dose and follow the regular dosing schedule. Do not take a double dose to compensate for the missed one.