Iloperidone belongs to ‘atypical antipsychotics’ class of medicines.
Uses of Iloperidone
It is used to treat recent mental disorders characterized by mood and behavioral changes like feeling things that are unreal or did not happen (acute schizophrenia).
Contraindications of Iloperidone
When should one not use Iloperidone
- If you have an allergy to Iloperidone or any of its ingredients
- If you have any psychiatric illness due to age-related brain problems such as memory, thinking or language problems (dementia related psychosis)
- If you have severe liver problems
Side effects of Iloperidone
Common side effects of this drug are:
- Dry mouth, dizziness, fatigue, running or stuffy nose
- Feeling sleepy (lethargy), fast heartbeats (tachycardia), weight gain
- Prolonged and slow heart rate (prolonged QTC interval) which can be fatal
- Dizziness, falling or fainting when getting up from sitting or lying position (orthostatic hypotension)
- High blood sugar and cholesterol levels which may increase the risk of heart disease and brain stroke
- Very high fever, elevated heart rate and blood pressure, tremors, stiff muscles and confusion – neuroleptic malignant syndrome (rare but serious)
- Severe allergic reactions including swelling of face, lips and throat causing swallowing and breathing problems, with or without rashes, itching, skin peeling and blisters (rare but serious)
Precautions and Warnings of Iloperidone
Can I take Iloperidone during pregnancy?
Iloperidone should be used with caution during the first six months of pregnancy (2 trimesters) only if other alternatives are not available. It should be avoided during the 3rd trimester (or last three months) of pregnancy.
Can I take Iloperidone while breastfeeding?
It is unknown if Iloperidone is secreted in breast milk. Still, because it has the potential to cause unwanted effects in the baby, it is recommended to avoid this medicine in breastfeeding mothers.
Can I drive if I have consumed Iloperidone?
This medicine may cause problems such as dizziness or drowsiness, reduced alertness, thinking learning and movement problems. You are advised to drive if you experience no such symptoms.
Can I consume alcohol with Iloperidone?
Avoid alcohol as it can increase the side effects due to Iloperidone.
Other General Warnings
Talk to your doctor if
- Inform your doctor if you develop any of the following:
- Increase in thirst, urination or hunger (due to high blood sugars)
- Low white blood cell counts
- Breast pain and discharge, irregular menstrual periods or impotence in males (due to increased levels of prolactin hormone)
- Reduced body temperature
- Suicidal thoughts
- History of seizures (fits)
- Prolonged erection (priapism)
- Uncontrolled movements of the face, tongue or other parts of the body (tardive dyskinesia) which may become permanent. You are advised to inform the doctor if you experience any such symptoms
- You should tell your doctor before surgery regarding all the products you use (including prescription medicines, non-prescription medicines and herbal products)
Mode of Action of Iloperidone
How Does It Work?
Iloperidone acts by reducing or suppressing the activity of the brain and thus calming the person. It does this by blocking the actions of substances that transmit signals in the brain (neurotransmitters such as Dopamine and Serotonin).
Interactions of Iloperidone
Interactions with other medicines
- Ketoconazole (antifungal)
- Certain antidepressants (Fluoxetine, Paroxetine)
- Few medicines which may increase the risk of irregular heartbeat (3 Procainamide, Quinidine, Sotalol)
- Certain antibiotics (such as Gatifloxacin, Moxifloxacin, Pentamidine)
- Antianxiety medicines (Prochlorperazine, Chlorpromazine, Trifluoperazine, Perphenazine, etc.)
- Methadone (opioid pain killer)
Interactions with food items
Iloperidone can be taken before or after meals.
Dosage of Iloperidone
Take Iloperidone in the exact dose as prescribed by your doctor. Inform the doctor in case of any overdose symptoms such as drowsiness, rapid heartbeat or feeling lightheaded.
Missed a Dose
Take the missed dose as early as you remember. If it is time for the next dose (less than 6 hours), skip the missed dose and continue your regular dosing schedule. Do not take a higher or a double dose of Iloperidone to compensate for the missed dose.
Frequently Asked Questions (FAQs)
Q: Is there anything else I need to know before taking Iloperidone?
- Iloperidone may affect your heart rhythm so inform the doctor if you experience any irregular, prolonged, forceful heartbeats or abnormal heart rhythms
- There could be potential weight gain due to Iloperidone as is the case with most of the medicines used to treat psychiatric illness
- This medicine may also cause you to fall and increase the risk of fractures
- Iloperidone can cause some severe side effects like prolonged and slow heart beats (prolonged QTC interval), irregular heartbeats and rhythms, uncontrollable movements of the face and tongue, swallowing problems, high blood sugars and cholesterol levels, menstrual irregularities in females, thinking and judgment problems, etc.read less
- You are advised to be cautious if you or anyone close to you is taking this medicine and report any observed side effects to the doctor promptly
- Iloperidone should not be used in patients less than 18 years of age and patients with liver disease
Q: Is Iloperidone an effective medicine?
- Iloperidone is believed to be an effective medicine to treat schizophrenia and is widely used with success. It works well and is better tolerated (lesser side effects) than most of the medicines used to treat this disorderread less
- This medicine has to be started at low doses and the required dose should be reached gradually. This is because Iloperidone may cause dizziness when standing up from sitting or lying position (orthostatic hypotension), especially during the start of the treatmentread less
- Due to this reason, it may take time for you to experience any relief of symptoms (like 1-2 weeks)
- Most of the side effects of Iloperidone occur when high doses are used and this medicine is usually safe at lower doses
- Drugbank. Iloperidone. [accessed on 2.Sep.2019]
- Drugbank. Iloperidone. [accessed on 2.Sep.2019]
- Webmd. Iloperidone. [accessed on 2.Sep.2019]
- Mayoclinic. Iloperidone. [accessed on 2.Sep.2019]
- Pubmed. Iloperidone. [accessed on 2.Sep.2019]
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Iloperidone. [Updated 2018 Dec 3]. Available from:
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)
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