Iloperidone

Molecule Description

Iloperidone belongs to ‘atypical antipsychotics’ class of medicines.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Iloperidone

It is used to treat recent mental disorders characterized by mood and behavioral changes like feeling things that are unreal or did not happen (acute schizophrenia).

Contraindications of Iloperidone

When should one not use Iloperidone

If you have an allergy to Iloperidone or any of its ingredients
If you have any psychiatric illness due to age-related brain problems such as memory, thinking or language problems (dementia related psychosis)
If you have severe liver problems

Side effects of Iloperidone

Common side effects of this drug are:

Drowsiness
Dry mouth, dizziness, fatigue, running or stuffy nose
Feeling sleepy (lethargy), fast heartbeats (tachycardia), weight gain
Prolonged and slow heart rate (prolonged QTC interval) which can be fatal
Dizziness, falling or fainting when getting up from sitting or lying position (orthostatic hypotension)
High blood sugar and cholesterol levels which may increase the risk of heart disease and brain stroke
Very high fever, elevated heart rate and blood pressure, tremors, stiff muscles and confusion – neuroleptic malignant syndrome (rare but serious)
Severe allergic reactions including swelling of face, lips and throat causing swallowing and breathing problems, with or without rashes, itching, skin peeling and blisters (rare but serious)

Precautions and Warnings of Iloperidone

Pregnancy

Can I take Iloperidone during pregnancy?

Iloperidone should be used with caution during the first six months of pregnancy (2 trimesters) only if other alternatives are not available. It should be avoided during the 3rd trimester (or last three months) of pregnancy.

Breast Feeding

Can I take Iloperidone while breastfeeding?

It is unknown if Iloperidone is secreted in breast milk. Still, because it has the potential to cause unwanted effects in the baby, it is recommended to avoid this medicine in breastfeeding mothers.

Driving

Can I drive if I have consumed Iloperidone?

This medicine may cause problems such as dizziness or drowsiness, reduced alertness, thinking learning and movement problems. You are advised to drive if you experience no such symptoms.

Alcohol

Can I consume alcohol with Iloperidone?

Avoid alcohol as it can increase the side effects due to Iloperidone.

Other General Warnings

Talk to your doctor if

Inform your doctor if you develop any of the following:
Increase in thirst, urination or hunger (due to high blood sugars)
Low white blood cell counts
Breast pain and discharge, irregular menstrual periods or impotence in males (due to increased levels of prolactin hormone)
Reduced body temperature
Suicidal thoughts
History of seizures (fits)
Prolonged erection (priapism)
Uncontrolled movements of the face, tongue or other parts of the body (tardive dyskinesia) which may become permanent. You are advised to inform the doctor if you experience any such symptoms
You should tell your doctor before surgery regarding all the products you use (including prescription medicines, non-prescription medicines and herbal products)

Mode of Action of Iloperidone

How Does It Work?

Iloperidone acts by reducing or suppressing the activity of the brain and thus calming the person. It does this by blocking the actions of substances that transmit signals in the brain (neurotransmitt...

Interactions of Iloperidone

Interactions with other medicines

Ketoconazole (antifungal)
Certain antidepressants (Fluoxetine, Paroxetine)
Few medicines which may increase the risk of irregular heartbeat (3 Procainamide, Quinidine, Sotalol)
Certain antibiotics (such as Gatifloxacin, Moxifloxacin, Pentamidine)
Antianxiety medicines (Prochlorperazine, Chlorpromazine, Trifluoperazine, Perphenazine, etc.)
Methadone (opioid pain killer)

Interactions with food items

Iloperidone can be taken before or after meals.

Dosage of Iloperidone

Overdose

Take Iloperidone in the exact dose as prescribed by your doctor. Inform the doctor in case of any overdose symptoms such as drowsiness, rapid heartbeat or feeling lightheaded.

Missed a Dose

Take the missed dose as early as you remember. If it is time for the next dose (less than 6 hours), skip the missed dose and continue your regular dosing schedule. Do not take a higher or a double dos...

Content Details

WRITTEN BY

Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: Is there anything else I need to know before taking Iloperidone?

Iloperidone may affect your heart rhythm so inform the doctor if you experience any irregular, prolonged, forceful heartbeats or abnormal heart rhythms
There could be potential weight gain due to Iloperidone as is the case with most of the medicines used to treat psychiatric illness
This medicine may also cause you to fall and increase the risk of fractures
Iloperidone can cause some severe side effects like prolonged and slow heart beats (prolonged QTC interval), irregular heartbeats and rhythms, uncontrollable movements of the face and tongue, swallowi...
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You are advised to be cautious if you or anyone close to you is taking this medicine and report any observed side effects to the doctor promptly
Iloperidone should not be used in patients less than 18 years of age and patients with liver disease

Q: Is Iloperidone an effective medicine?

Iloperidone is believed to be an effective medicine to treat schizophrenia and is widely used with success. It works well and is better tolerated (lesser side effects) than most of the medicines used ...
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This medicine has to be started at low doses and the required dose should be reached gradually. This is because Iloperidone may cause dizziness when standing up from sitting or lying position (orthost...
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Due to this reason, it may take time for you to experience any relief of symptoms (like 1-2 weeks)
Most of the side effects of Iloperidone occur when high doses are used and this medicine is usually safe at lower doses

References

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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