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Molecule Description

Desloratadine belongs to a group of medicines called ‘antihistamines’ and is available in tablet and syrup forms.

Uses of Desloratadine

  • Sneezing, runny nose, and watery eyes due to dust, pollen or animal (pets) allergy (allergic rhinitis)
  • To relieve rashes or patches with itching (urticaria or hives)

Contraindications of Desloratadine

When should one not use Desloratadine

Allergy to Desloratadine or any of its ingredients or similar medicines, such as Loratidine.

Side effects of Desloratadine

Common side effects of this drug are:

  • Fatigue, headache, dry mouth
  • Weakness, aggression, irregular heartbeats, abnormal behavior, irregular heartbeats, increased sensitivity to sun, yellow skin or eyes (jaundice) increased hunger, weight gain (uncommon)
  • Stomach upset, loose motions, dizziness, drowsiness, restlessness, muscle pains, stomach pain, vomiting, liver problems (rare)

Precautions and Warnings of Desloratadine


Can I take Desloratadine during pregnancy?
Though there is no evidence to indicate that Desloratadine harms the baby, it is recommended to avoid this medicine during pregnancy due to lack of sufficient data.

Breast Feeding

Can I take Desloratadine while breastfeeding?
Desloratadine is secreted in breast milk and has to be used in breastfeeding women only if other alternatives are not available.


Can I drive if I have consumed Desloratadine?
Desloratadine usually doesn’t affect your ability to drive, but can cause side effects such as drowsiness or reduced alertness. You are advised not to drive in the presence of such symptoms.


Can I consume alcohol with Desloratadine?
It is unsafe to consume alcohol with Desloratadine. It may cause more dizziness or drowsiness. Unpleasant reactions, such as skin redness, chest tightness, etc., have been reported.

Other General Warnings

Talk to your doctor if
  • Inform the doctor if you have:
  • Severe kidney disease
  • In patients with known or family history of seizures (fits)

Mode of Action of Desloratadine

How Does It Work?

Allergy or insensitivity to certain substances like dust, pollen, medications, pets, chemicals (external or internal), foods, etc., causes the immune system to release certain substances called histamines which results in symptoms such as running nose, watery eyes, itching, rashes, skin patches, etc. Desloratadine blocks the actions of this histamine and thus causes recovery from symptoms.
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Interactions of Desloratadine

Interactions with other medicines

  • No known interactions
  • Inform the doctor about all the products you use including prescription medicines, non-prescription medicines, and herbal products

Interactions with food items

You can take Desloratadine with or without food.

Dosage of Desloratadine


Accidental overdose of Desloratadine may not be harmful. But if you experience any symptoms such as drowsiness, headache, or dry mouth, consult your doctor.

Missed a Dose

As Desloratadine is usually given once a day, you can take any missed dose as soon as you remember. If your next dose is close, skip the missed dose and continue as per your regular dosage schedule. Do not take a higher or a double dose of medicine to make up for the missed dose.
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Frequently Asked Questions (FAQs)


Q: Is Desloratadine an effective medicine for allergy?

  • Allergic rhinitis (running nose, watery eyes) and urticaria (severe itchy, red rashes on the skin) are common problems due to seasonal or specific triggering factors (cold weather, infections, dust, pollen, foods, pets, chemicals, etc.)
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  • The effects of Desloratadine last for an extended period when compared to similar medicines and also causes less drowsiness or sleepiness, which is familiar with this class of medicines
  • Desloratadine gives quick relief and causes lesser side effects than other treatments offered for this purpose
  • It was also proven to be effective in relieving watery nose and improving the airflow through the nose

Q: Is there anything else I need to know before using Desloratadine?

  • The tablet form is usually recommended in patients above 12 years of age, and the syrup for children below 12 years
  • Use this medicine with caution in patients who have seizures (fits) or a family history of the same
  • In case of running nose, you can stop taking Desloratadine after relief of symptoms. But, in the presence of prolonged or severe symptoms, that continue for weeks, it may have to be taken for more extended periods of time
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  • For urticaria (itchy rashes), the treatment duration may vary from person to person
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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