Dabigatran
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Molecule Summary
| Uses | Treatment and prevention of deep vein thrombosis and pulmonary embolism, prevention of stroke in atrial fibrillation |
| Therapy | Anti-Coagulant |
| Side Effects | Bleeding or bruising, stomach ache, feeling sick, indigestion, loose motions, anaemia |
Medicines
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Molecule Description
Dabigatran is an anticoagulant medicine. It is used to treat and prevent deep vein thrombosis (formation of blood clots in the deep vein of your body, usually your legs) and pulmonary embolism (blood clot in the blood vessels of the lungs). It is also used for the prevention of stroke, systemic embolism and reduction of vascular mortality in adult patients with atrial fibrillation. It works by preventing the formation of a blood clot. Do not stop taking this medicine or miss a dose of this medicine without talking to your doctor. Continue to take this medicine even if you feel well. Make sure to refill your prescription before you run out of medication so that you will not miss a dose.
Uses
- Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) and prevention of related death.
- To prevent recurrence of deep vein thrombosis (DVT) and pulmonary embolism (PE).
- To prevent blood clots in the brain (stroke) and other blood vessels in the body if you have a form of irregular heart rhythm (atrial fibrillation).
Contraindications
When should one not use Dabigatran
Known allergy to dabigatran etexilate or any of the other ingredients of this medicine.
If you have reduced kidney or liver function, a bleeding disorder or have a disease that increases the risk of bleeding.
If you are taking medicines to prevent blood clotting (e.g. warfarin, rivaroxaban, apixaban or heparin).
If you are taking oral antifungals such as ketoconazole, cyclosporin (used to prevent organ rejection after transplantation), dronedarone (to treat abnormal heartbeat) and antiviral medicines such as glecaprevir and pibrentasvir.
Side effects
Common side effects of this drug are:
- Bleeding or bruising
- Stomach ache
- Feeling sick
- Indigestion
- Loose motions
- Anaemia
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have any bleeding disorder, bleeding in any part of your gut, ulcers, skin lesions.
- You have had a surgical tissue removal (biopsy) in the past month.
- You had an injury recently and still recovering from that (bone fracture, head injury or any injury requiring surgical treatment).
- You have swelling or inflammation in the food pipe & stomach or stomach acid comes up to the food pipe.
- Your kidneys and liver are not functioning properly.
- Your weight is less than 50 kgs or you are an elderly person (over 75 years).
- You need to have an operation. You will be asked to stop taking this medicine for a while to avoid the risk of bleeding. Make sure you take Dabigatran before and after the operation exactly at the times you have been told by your doctor.
- You are going to undergo an operation that involves a catheter or injection into your spinal column.
Mode of Action
How Does It Work?
Dabigatran works by inhibiting the action of an enzyme involved in the blood clotting and hence increases the clotting time.
Interactions
Interactions with other medicines
- Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, supplements or herbals.
- Certain medicines such as oral antifungals such as ketoconazole, cyclosporin (used to prevent organ rejection after transplantation), dronedarone (to treat abnormal heartbeat) and antiviral medicines such as glecaprevir and pibrentasvir should not be taken with Dabigatran.
- Concomitant use of tacrolimus (used during organ rejection) and Digoxin (used for heart conditions) is not recommended with Dabigatran.
- Caution to be exercised in case of concomitant use of certain medicines such as Verapamil (for high blood pressure), Amiodarone & Quinidine (used for heart conditions), Clarithromycin (an antibiotic) and Posaconazole (an antifungal).
- Concomitant use of medicines such as rifampicin, carbamazepine or phenytoin should be avoided.
- Other anticoagulants & antiplatelet agents if taken along with Dabigatran may increase the risk of bleeding.
Dosage
Overdose
Taking too much of this medicine increases the risk of bleeding. In case of an overdose contact your doctor immediately or reach out to the nearest hospital.
Missed a Dose
Take the forgotten dose as soon as you remember. If it's already time for the next dose then skip the missed dose and follow the usual dosing schedule. You should never miss the dose of this medicine as it may lead to an increased risk of clot formation.
Frequently Asked Questions (FAQs)
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