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Clozapine

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Molecule Summary

Uses
Schizophrenia
Therapy
Anti-Psychotics
Side Effects
Drowsiness, Dizziness, Dry mouth, Restlessness, Headache, Constipation, Fainting, Insomnia, Nausea, Vomiting
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Molecule Description

Clozapine is a prescription medicine indicated for patients who have Schizophrenia. It is a type of mental illness in which a person has hallucinations and cannot differentiate between reality and imaginary life.

Uses

  • Clozapine is indicated for the patient who has Schizophrenia.

Contraindications

When should one not use Clozapine

  • You are allergic or hypersensitive to Clozapine.
  • You cannot get the blood tests done frequently for some reason.
  • You have a history of low blood cell count, specifically neutrophil count (agranulocytosis).
  • You have bone marrow disease.
  • You have uncontrolled epilepsy.
  • You have severe liver or heart disease.

Side effects

Common side effects of this drug are:

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Restlessness
  • Headache
  • Constipation
  • Fainting
  • Insomnia
  • Nausea
  • Vomiting

Precautions and Warnings

Pregnancy

Pregnancy

Clozapine is generally avoided in pregnancy. It had been seen to affect the baby when mothers consumed Clozapine in the last trimester of pregnancy. The babies exhibited symptoms like agitation, tremors, respiratory and feeding issues.

Pregnancy

Pregnancy

Please inform your doctor if you are pregnant or planning pregnancy to get suitable advice.

Breast Feeding

Breast Feeding

Clozapine has been proved to pass through human milk. Hence, breastfeeding while taking Clozapine should be avoided. Please inform your doctor if you are breastfeeding to get the best advice.

Driving

Driving

Clozapine can affect the ability to drive because of side effects like drowsiness and dizziness. Please notice how the medicine affects you for a few days before driving any vehicle.

Alcohol

Alcohol

Alcohol can increase the severity of drowsiness and dizziness. For this reason, alcohol consumption should be avoided while taking Clozapine.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have a medical history of kidney, liver, lung, or mental disorders.
  • You or any family member has a history of depression, has had suicidal thoughts.
  • You have a blood disorder.
  • You have withdrawal symptoms like headache, muscle pain, restlessness, anxiety, sweating, diarrhoea, confusion etc. Do not discontinue the medicine without consulting your doctor first.
  • You want to drive a vehicle or operate heavy machinery after taking Clozapine.
  • You notice any vision changes, like blurred vision.
  • You notice a spike in blood sugar. Clozapine can increase blood sugar. Please inform the doctor immediately in such a case.
  • You notice any changes in the blood count.
  • You notice extreme tiredness, troubled breathing, fever, chest pain or fast heartbeat. Clozapine is known to cause Myocarditis (heart disorder).
  • You have seizures after taking Clozapine.

Mode of Action

How Does It Work?

Clozapine is a type of atypical antipsychotic. It acts by regulating the balance of certain chemicals in the brain that helps in relieving the symptoms and provides the patient with some clarity of thought.

Dosage

Overdose

Overdose of Clozapine can lead to symptoms like drowsiness, dizziness, coma, confusion, respiratory depression, hallucination, agitation etc. Please take the affected individual to the hospital right away.

Missed a Dose

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and stick to the usual schedule. Do not double the dose to compensate as it can lead to severe side effects.

Frequently Asked Questions (FAQs)

Please report the symptoms to the doctor immediately to avoid any complications. Clozapine can result in such side effects, but please inform your doctor to get the best solution.

No specific diet is required while taking Clozapine. Maintain a healthy lifestyle, including a balanced diet and physical activity every day.

High blood sugar is one of the common side effects of Clozapine. Please inform your doctor about the latest blood sugar levels to get the best advice.

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