Cisapride

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Molecule Description

Cisapride is a prokinetic medicine that is used to treat heartburn (particularly night time heartburn), diabetic gastroparesis, delayed gastric emptying, indigestion, and gastric ulcer. It is also used to treat inflamed oesophagus.

Uses

To treat heartburn due to gastroesophageal reflux disease
To treat stomach problem associated with diabetes (diabetic gastroparesis)
To treat indigestion and gastric ulcer

Contraindications

When should one not use Cisapride

Allergic reaction to this medicine
History of prolonged QT syndrome
Family history of cardiac arrhythmia
History of renal failure, heart failure, electrolyte disorders, and respiratory failure

Side effects

Common side effects of this drug are:

Common side effects of cisapride include the following:
Headache
Diarrhea
Abdominal pain
Anxiety
Nausea
Dizziness
Urinary frequency
Bronchospasm in asthma patients
Serious side effects include:
Palpitations
Gynecomastia
Ventricular tachycardia (abnormally increased heartbeat)
Seizures
Psychiatric disturbances

Precautions and Warnings

Pregnancy

You should not take Cisapride during pregnancy, because the safety of this medicine for use during pregnancy has not been established.

Breast Feeding

Low levels of this medicine pass in breast milk; its use in nursing mothers is acceptable if it is required.

Driving

Avoid driving, as Cisapride causes dizziness and can impair a person's ability to drive.

Alcohol

Alcohol can cause more drowsiness when taken with this medicine.

Other General Warnings

Talk to your doctor if

Life-threatening heart problems like cardiac arrhythmia can happen with this medicine
Heart attacks and sudden death have occurred with this medicine even with those people who are not at risk of developing heart problems
You have conditions like rash or skin itching, abnormal voice changes, trouble to breathe, difficult to swallow, or in case any swelling to your hands, face, or mouth while taking this medicine
You are taking any other medicines including prescription medicines, non-prescription medicines, and herbal products

Mode of Action

How Does It Work?

Cisapride acts by increasing movement of food inside the stomach and the intestine during the process of digestion. It also works by increasing the rate at which the stomach empties its content into the small intestine. It releases more acetylcholine into the stomach and increases the pressure in the pyloric sphincter (the muscle that is present between your stomach and your small intestine), thereby increasing the gastric emptying time.

Interactions

Interactions with other medicines

Antianxiety medications
Anticholinergics (Atropine, Belladonna, Benztropine, Dicyclomine, Diphenhydramine, Isopropamide, Procyclidine, and Scopolamine)
Blood thinner medicine such as Warfarin
Azithromycin
Cimetidine
Dirithromycin
Diuretics
Miconazole
Tranquilizers
Vitamins

Interactions with food items

Grape juice or grape fruit will reduce the effectiveness of this medicine.

Dietary Restrictions

Avoid drinking grape juice or eating grape fruit while taking cisapride. Consult the physician, pharmacist, and nutritionist regarding diet restrictions.

Dosage

Overdose

Take Cisapride precisely as prescribed. Taking more medication than prescribed, will only cause more side effects like severe cardiac arrhythmias and sudden death. If you feel palpitations or unusual heartbeat, contact the nearest medical emergency department immediately.

Missed a Dose

If you missed any dose, take it as early as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of medicine to compensate for a missed one.

Frequently Asked Questions (FAQs)

You can take this medicine if you experience nighttime heartburn. However, you should not take Cisapride without a doctor's prescription.

No. This medication should be taken with a valid prescription and should be taken as prescribed.

Atropine is an anticholinergic medicine that acts by reducing the motility of stomach muscles. Thereby, it prevents the action of Cisapride, whose purpose is to increase the movements of stomach muscles.

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