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Molecule Description

Cisapride is a prokinetic medicine that is used to treat heartburn (particularly night time heartburn), diabetic gastroparesis, delayed gastric emptying, indigestion, and gastric ulcer. It is also used to treat inflamed oesophagus.
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Uses of Cisapride

  • To treat heartburn due to gastroesophageal reflux disease
  • To treat stomach problem associated with diabetes (diabetic gastroparesis)
  • To treat indigestion and gastric ulcer

Contraindications of Cisapride

When should one not use Cisapride

  • Allergic reaction to this medicine
  • History of prolonged QT syndrome
  • Family history of cardiac arrhythmia
  • History of renal failure, heart failure, electrolyte disorders, and respiratory failure

Side effects of Cisapride

Common side effects of this drug are:

  • Common side effects of cisapride include the following:
  • Headache
  • Diarrhea
  • Abdominal pain
  • Anxiety
  • Nausea
  • Dizziness
  • Urinary frequency
  • Bronchospasm in asthma patients
  • Serious side effects include:
  • Palpitations
  • Gynecomastia
  • Ventricular tachycardia (abnormally increased heartbeat)
  • Seizures
  • Psychiatric disturbances

Precautions and Warnings of Cisapride


Can I take Cisapride during pregnancy?
You should not take Cisapride during pregnancy, because the safety of this medicine for use during pregnancy has not been established.

Breast Feeding

Can I take Cisapride while breastfeeding?
Low levels of this medicine pass in breast milk; its use in nursing mothers is acceptable if it is required.


Can I drive if I have consumed Cisapride?
Avoid driving, as Cisapride causes dizziness and can impair a person's ability to drive.


Can I consume alcohol with Cisapride?
Alcohol can cause more drowsiness when taken with this medicine.

Other General Warnings

Talk to your doctor if
  • Life-threatening heart problems like cardiac arrhythmia can happen with this medicine
  • Heart attacks and sudden death have occurred with this medicine even with those people who are not at risk of developing heart problems
  • You have conditions like rash or skin itching, abnormal voice changes, trouble to breathe, difficult to swallow, or in case any swelling to your hands, face, or mouth while taking this medicine
  • You are taking any other medicines including prescription medicines, non-prescription medicines, and herbal products

Mode of Action of Cisapride

How Does It Work?

Cisapride acts by increasing movement of food inside the stomach and the intestine during the process of digestion. It also works by increasing the rate at which the stomach empties its content into the small intestine. It releases more acetylcholine into the stomach and increases the pressure in the pyloric sphincter (the muscle that is present between your stomach and your small intestine), thereby increasing the gastric emptying time.
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Interactions of Cisapride

Interactions with other medicines

  • Antianxiety medications
  • Anticholinergics (Atropine, Belladonna, Benztropine, Dicyclomine, Diphenhydramine, Isopropamide, Procyclidine, and Scopolamine)
  • Blood thinner medicine such as Warfarin
  • Azithromycin
  • Cimetidine
  • Dirithromycin
  • Diuretics
  • Miconazole
  • Tranquilizers
  • Vitamins

Interactions with food items

Grape juice or grape fruit will reduce the effectiveness of this medicine.

Dietary Restrictions of Cisapride

Avoid drinking grape juice or eating grape fruit while taking cisapride. Consult the physician, pharmacist, and nutritionist regarding diet restrictions.

Dosage of Cisapride


Take Cisapride precisely as prescribed. Taking more medication than prescribed, will only cause more side effects like severe cardiac arrhythmias and sudden death. If you feel palpitations or unusual heartbeat, contact the nearest medical emergency department immediately.
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Missed a Dose

If you missed any dose, take it as early as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of medicine to compensate for a missed one.
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Content Details


Dr. Rukman Mecca

MBBS, MD (Community Medicine)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: When should I use this medicine?

A: You can take this medicine if you experience nighttime heartburn. However, you should not take Cisapride without a doctor's prescription.

Q: Can I take this medicine without a prescription?

A: No. This medication should be taken with a valid prescription and should be taken as prescribed.

Q: What interactions could be seen if someone uses Atropine along with Cisapride?

A: Atropine is an anticholinergic medicine that acts by reducing the motility of stomach muscles. Thereby, it prevents the action of Cisapride, whose purpose is to increase the movements of stomach muscles.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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