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Bosentan

Molecule Description

Bosentan is a medicine used for treating high blood pressure in the lungs (known as pulmonary arterial hypertension).

Uses of Bosentan

It is used to treat ulcers on fingers and toes, patient with a skin disease called scleroderma.

Contraindications of Bosentan

When should one not use Bosentan

  • If you have an allergy to Bosentan
  • If you have moderate to severe liver disease
  • If you are taking Ciclosporin A medicine
  • If you are pregnant

Side effects of Bosentan

Common side effects of this drug are:

  • Decrease in haemoglobin count
  • Jaundice
  • Dark coloured urine
  • Itching of skin
  • Fainting
  • Headache
  • Swelling over legs, ankles, etc
  • Redness of skin, rash over skin
  • Loose motions
  • Nausea and vomiting

Precautions and Warnings of Bosentan

Pregnancy

Q:
Can I take Bosentan during pregnancy?
A:
It is probably unsafe to use this medicine during pregnancy as this can cause an adverse effect in an unborn baby.

Breast Feeding

Q:
Can I take Bosentan while breastfeeding?
A:
It is unknown whether this medicine passes into breast milk or not. Therefore, avoid breastfeeding when on this medication.

Driving

Q:
Can I drive if I have consumed Bosentan?
A:
This medicine may lead to the cause of blurred vision. Do not drive unless you feel well.

Alcohol

Q:
Can I consume alcohol with Bosentan?
A:
Alcohol has to be avoided when on this medication.

Other General Warnings

Talk to your doctor if
  • Blood tests are required to see your liver function, haemoglobin count, before you start treatment of Bosentan and each month after using it
  • It is useful to do urine tests to check for any unwanted effects

Mode of Action of Bosentan

How Does It Work?

It decreases both pulmonary and systemic vascular resistance and causes blood vessels to expand, which results in increased cardiac output without increasing heart rate.

Interactions of Bosentan

Interactions with other medicines

  • Ciclosporin A
  • Hormonal contraceptives
  • Glibenclamide (for diabetes)
  • Medicines used to prevent rejection of transplanted organs (like Tacrolimus, Sirolimus)
  • Fluconazole, Ketoconazole, Itraconazole (to treat fungal infections)
  • Warfarin (an anticoagulant agent)
  • Sildenafil and Tadalafil

Interactions with food items

No information is available on interactions of Bosentan when taken with food, consult your doctor or pharmacist for further details.

Dietary Restrictions of Bosentan

No information is available on dietary restrictions while you are taking Bosentan, consult your doctor or pharmacist for further information.

Dosage of Bosentan

Overdose

Symptoms of overdose of Bosentan include dizziness, fainting, fast heartbeat, light-headedness, nausea, severe headache, vomiting, etc. Seek emergency medical attention immediately.

Missed a Dose

If you missed any dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose to compensate for the missed dose.
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Content Details

WRITTEN BY
doctor

Dr. Arpit Verma

MBBS, MD (Pharmacology)

REVIEWED BY
doctor

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

^

Q: What should I consult with my doctor before taking Bosentan?

A: Give a detailed account of your medical and surgical history. Also, mention to your doctor all the prescription and non-prescription medicines, herbal preparations and nutritional supplements that you may be taking before you start this medication.

Q: Is there any precaution to follow?

A: Due to the potential for severe liver injury, including rare cases of liver failure, liver function tests must be done before starting the treatment and then periodically after that. This drug makes oral hormonal contraceptives ineffective. Discuss another/ additional form of contraception with your doctor while on this medicine.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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