Bosentan is a medicine used for treating high blood pressure in the lungs (known as pulmonary arterial hypertension).
Uses of Bosentan
It is used to treat ulcers on fingers and toes, patient with a skin disease called scleroderma.
Contraindications of Bosentan
When should one not use Bosentan
- If you have an allergy to Bosentan
- If you have moderate to severe liver disease
- If you are taking Ciclosporin A medicine
- If you are pregnant
Side effects of Bosentan
Common side effects of this drug are:
- Decrease in haemoglobin count
- Dark coloured urine
- Itching of skin
- Swelling over legs, ankles, etc
- Redness of skin, rash over skin
- Loose motions
- Nausea and vomiting
Precautions and Warnings of Bosentan
Can I take Bosentan during pregnancy?
It is probably unsafe to use this medicine during pregnancy as this can cause an adverse effect in an unborn baby.
Can I take Bosentan while breastfeeding?
It is unknown whether this medicine passes into breast milk or not. Therefore, avoid breastfeeding when on this medication.
Can I drive if I have consumed Bosentan?
This medicine may lead to the cause of blurred vision. Do not drive unless you feel well.
Can I consume alcohol with Bosentan?
Alcohol has to be avoided when on this medication.
Other General Warnings
Talk to your doctor if
- Blood tests are required to see your liver function, haemoglobin count, before you start treatment of Bosentan and each month after using it
- It is useful to do urine tests to check for any unwanted effects
Mode of Action of Bosentan
How Does It Work?
It decreases both pulmonary and systemic vascular resistance and causes blood vessels to expand, which results in increased cardiac output without increasing heart rate.
Interactions of Bosentan
Interactions with other medicines
- Ciclosporin A
- Hormonal contraceptives
- Glibenclamide (for diabetes)
- Medicines used to prevent rejection of transplanted organs (like Tacrolimus, Sirolimus)
- Fluconazole, Ketoconazole, Itraconazole (to treat fungal infections)
- Warfarin (an anticoagulant agent)
- Sildenafil and Tadalafil
Interactions with food items
No information is available on interactions of Bosentan when taken with food, consult your doctor or pharmacist for further details.
Dietary Restrictions of Bosentan
No information is available on dietary restrictions while you are taking Bosentan, consult your doctor or pharmacist for further information.
Dosage of Bosentan
Symptoms of overdose of Bosentan include dizziness, fainting, fast heartbeat, light-headedness, nausea, severe headache, vomiting, etc. Seek emergency medical attention immediately.
Missed a Dose
If you missed any dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose to compensate for the missed dose.
Frequently Asked Questions (FAQs)
Q: What should I consult with my doctor before taking Bosentan?
A: Give a detailed account of your medical and surgical history. Also, mention to your doctor all the prescription and non-prescription medicines, herbal preparations and nutritional supplements that you may be taking before you start this medication.
Q: Is there any precaution to follow?
A: Due to the potential for severe liver injury, including rare cases of liver failure, liver function tests must be done before starting the treatment and then periodically after that. This drug makes oral hormonal contraceptives ineffective. Discuss another/ additional form of contraception with your doctor while on this medicine.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)
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