Amikacin

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Molecule Description

Amikacin belongs to Aminoglycoside antibiotics class that is used to prevent or treat bacterial infections.

Uses

Amikacin is an antibiotic used to treat conditions such as serious infection by certain bacteria, including joint infection, intra-abdominal infections, pneumonia, and urinary tract infections.

Contraindications

When should one not use Amikacin

A known allergy to any aminoglycoside
You suffer from a disease called myasthenia gravis (severe weakness)
If you have hearing difficulty, nerve problems or kidney problem

Side effects

Common side effects of this drug are:

Skin rash
Cough
Dizziness
Drowsiness
Fever
Headache
Loss of balance
Nausea, vomiting
Low blood pressure
Deafness
Severe kidney failure
Decrease in the number of red blood cells in the blood (anemia) or excessive amounts of the white blood cells known as Eosinophils in the blood (eosinophilia)

Precautions and Warnings

Pregnancy

It is not recommended by experts to use this medicine during pregnancy. This medicine can cause fetal harm when taken by a pregnant woman.

Breast Feeding

Amikacin passes into breast milk in small amounts. Consult your doctor before breastfeeding.

Driving

If you experience any side effects like dizziness during treatment, then avoid driving.

Alcohol

Interaction with alcohol is unknown.

Other General Warnings

Talk to your doctor if

Have kidney problems
You have hearing difficulties or tinnitus (ringing or buzzing in the ears)
Amikacin may cause live bacterial vaccines (such as typhoid vaccine) not to work well. Do not have any immunizations or vaccinations while using this medication unless your doctor advises you.
Amikacin may cause kidney damage, hearing loss for the elderly population, or infants who are on a higher dose of Amikacin; hence, one has to be cautious while giving this medicine to elderly or infants.

Mode of Action

How Does It Work?

Amikacin works by stopping the growth of bacteria.

Interactions

Interactions with other medicines

It is essential to let your doctor know about all the medications you are taking. Medicines that may interact with Mikacin include Amphotericin B, Cephalosporin, Cisplatin, Cyclosporine, Diuretics like Furosemide, and Ethacrynic Acid, anti-inflammatory drugs (NSAIDs) such as Ibuprofen, other Aminoglycosides and can increase the risk of kidney damage or hearing loss.

Dosage

Overdose

Overdose of Amikacin cause severe kidney damage, after which the patient may need to be on lifelong peritoneal dialysis or hemodialysis.

Missed a Dose

If you have missed an Amikacin regular dose, then call your doctor and fix up an appointment as soon as you can. It is not advisable to miss a dose of antibiotics. It may lead to antibiotic resistance.

Frequently Asked Questions (FAQs)

Use this medicine with or without food. Take extra fluids while on treatment with this medicine. Do not take it in large amounts as it may cause undesirable effects.

Give a detailed account of your medical and surgical history. Also, mention your doctor all the prescription and non-prescription medicines, herbal preparations, and nutritional supplements that you may be taking before starting this medication.

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