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Zerodol MR Tablet

10 Tablet(s) in Strip
By IPCA LABORATORIES
Salt: Aceclofenac 100.0 Mg+Tizanidine 2.0 Mg
MRP ₹128
₹97.28 24% OFF
₹9.73/Tablet (Inclusive of all taxes)
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30 days easy return policy
✱Offer applicable on order above ₹1000
Zerodol Mr Strip Of 10 Tablets

Product Summary

Zerodol MR Tablet is used to treat acute low back pain, muscle spasms and pain from muscle sprains, strains or injuries. It combines aceclofenac 100 mg, which reduces pain and inflammation, with tizanidine 2 mg, which relaxes muscles; Ipca Laboratories manufactures this painkiller and muscle-relaxant combination.

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IPCA LABORATORIES

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General Information

Therapy		 Muscle relaxant, analgesic
Composition		 Aceclofenac(100.0 Mg)+Tizanidine(2.0 Mg) Aceclofenac 100.0 Mg+Tizanidine 2.0 Mg
Zerodol MR Tablet
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30 days easy return policy

*Offer applicable on orders above ₹1000

About Zerodol

Zerodol MR tablets are used to relieve pain and inflammation caused by conditions such as arthritis, back pain, joint pain, and muscle spasms. This medicine combines two active ingredients: aceclofenac, which helps reduce pain and inflammation, and tizanidine, which relaxes tight or stiff muscles to ease discomfort. Together, they work to improve movement and help you feel more comfortable during daily activities.

Many people find this medication helpful for conditions characterised by both pain and muscle tightness. It is essential to take the tablet exactly as your doctor prescribes, typically with food to minimise stomach upset. Taking it after a meal can also help reduce the risk of side effects, such as nausea or acidity. Do not take more than the recommended dose, even if you feel the pain is severe.

Some people may experience side effects such as dizziness, dry mouth, or stomach discomfort. If you feel nauseous, try eating small, light meals throughout the day. Sucking on sugar-free lozenges or drinking water can help relieve dry mouth. Make sure to stay hydrated and avoid alcohol while taking this medicine, as it may worsen side effects like drowsiness or stomach irritation.

Before starting Zerodol MR, tell your doctor if you are pregnant, trying to get pregnant, or breastfeeding. Also inform them if you have any medical conditions, especially related to your liver, kidneys, or heart.

Uses

Zerodol-MR tablet is a combination medication used to treat pain and inflammation caused by osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, tooth pain, bone and joint pain and headache.

Doctor’s suggestion

Dr. Vishesh Bharucha
Dr. Vishesh Bharucha MBBS, MD Medicine ★★★★★
Zerodol MR is most appropriate for short-term management of acute painful muscle spasm not for persistent pain or long term use.

Contraindications

  • If you are allergic to aceclofenac tizanidine, or any other ingredients of this medicine.
  • If you are allergic to other painkillers (or NSAIDs) like Ibuprofen, Aspirin, and Diclofenac.
  • If you have a history of stomach ulcers or bleeding, bleeding or perforation (tear) from the gastrointestinal tract.
  • If you have any bleeding or blood clotting disorders or blood circulation problems.
  • If you have heart problems like stroke, heart attack or heart failure.
  • If you have a history of severe allergic reactions upon painkiller consumption, like asthmatic attack, runny nose and skin reactions.
  • If you're suffering from any liver or kidney disease.
  • If you are taking medications like Fluvoxamine (used to treat psychiatric illness) or ciprofloxacin (antibiotic).
  • If you are pregnant or are planning to have a baby.

Side effects

  • Dizziness
  • Nausea
  • Vomiting
  • Stomach pain
  • Indigestion
  • Dry mouth
  • Constipation
  • Flu
  • Weakness
  • Tiredness
  • Sleepiness
  • Urinary tract infection

Precautions and Warnings

Alcohol

Alcohol

UNSAFE

It is recommended not to consume alcohol while taking the Zerodol MR tablet, as alcohol can lead to an increase in the side effects of this medicine.

Pregnancy

Pregnancy

UNSAFE

There is limited information about the safety of the Zerodol MR tablet in human pregnancy but components of this medicine are known to be unsafe in pregnancy. Therefore, it should not be used during pregnancy.

Breast feeding

Breastfeeding

WITH CAUTION

It is unknown if the Zerodol MR tablet passes into the human breastmilk and there is limited information available on its safety on the breastfed infant and lactating women. Consult your doctor before using this medicine during breastfeeding.

Driving

Driving

WITH CAUTION

You may experience visual disturbances, inability to recognise objects properly, dizziness, sleepiness while on treatment with the Zerodol MR tablet. Therefore, you should avoid driving if you do not feel well or are unable to be alert.

General warnings

Other General Warnings

Talk to your doctor if
  • You have problems with your heart, kidney, liver function, or any other pre-existing health condition.
  • You have stomach or intestine issues like bleeding, inflammatory bowel disease or stomach tumour.
  • You have blood circulation problems or bleeding disorders or are taking blood thinners.
  • You have a condition known as porphyria lupus or chickenpox.
  • You have asthma or breathing issues or are a smoker.
  • You have diabetes, high blood pressure, high cholesterol, or fats.
  • You recently had major surgery and are recovering from it.

Directions for use

  • Take the Zerodol MR tablet as a whole with a sufficient amount of water, after your meal to avoid stomach discomfort.
  • Take it regularly and without fail as directed by your doctor and do not consume it more than that prescribed by your doctor.

Storage and disposal

  • Store the Zerodol MR tablet below 25°C in a clean and dry place, protected from moisture, sunlight and heat.
  • Keep the medicine away from children and pets.
  • Discard any unused or expired medicine properly, do not flush in the toilet or throw it into the drain.

Quick tips

  • Before taking this medicine, inform your doctor about all your medications and medical history.
  • Zerodol-MR has side effects, including nausea, diarrhoea, indigestion, stomach pain, and dizziness. If these side effects bother you, please inform your doctor.
  • Take Zerodol MR tablet with food to avoid stomach upset or nausea.
  • Zerodol MR tablet is not a steroid; it contains Aceclofenac and Tizanidine, which belong to the group of medicines called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) and Skeletal Muscle Relaxants, respectively.
  • This medicine may potentially impact liver function and cause variations in liver enzyme levels. It is contraindicated for use in children and individuals over 65 years of age.

Dosage

Overdose

If you overdose on Zerodol MR, you may experience symptoms such as nausea, vomiting, headache, dizziness, ringing in the ears, confusion, low blood pressure, breathing problems, and coma. In case you experience any of these symptoms or think you've taken too much of this medicine, contact your doctor immediately or visit the nearest hospital. Overdosing on Zerodol MR can also lead to liver or kidney impairment.

Missed a dose

If you have missed taking any dose of the Zerodol MR tablet, take it as soon as you remember. If it's time for your next dose, skip the missed dose and continue with your regular dose schedule. Do not take a double dose of medicine to compensate for the missed one

How Zerodol works

Zerodol MR tablet contains a combination of aceclofenac and tizanidine. Aceclofenac is a painkiller that works by blocking certain chemicals in the body responsible for pain, swelling, and inflammation. Tizanidine is a muscle relaxant that relieves muscle spasms and pain by interrupting signal transmission in the brain and spinal cord.

Interactions

Drug interactions of Zerodol with other medicine salt

Lithium

Severe

zerodol mr may reduce lithium excretion, increasing toxicity risk (e.g., tremors, confusion).

Digoxin

Severe

May worsen heart failure and increase digoxin levels, leading to toxicity (e.g., arrhythmia).

Ciprofloxacin

Severe

When taken with tizanidine, Ciprofloxacin can increase blood levels of tizanidine, raising the risk of dangerous side effects such as severe sleepiness, low blood pressure, or fainting.

Fluvoxamine

Severe

Fluvoxamine strongly inhibits liver enzymes, which are responsible for breaking down tizanidine. This can cause tizanidine levels in the blood to increase drastically, leading to serious side effects such as extreme drowsiness, low blood pressure, and slowed heart rate.

Ciclosporin

Severe

Increased risk of kidney damage due to reduced prostaglandin production.

Prednisolone

Severe

Increased risk of stomach ulcer or bleeding when taken together.

Ibuprofen

Severe

Increased risk of stomach ulcers, gastrointestinal bleeding, and kidney damage when two NSAIDs are used together.

Celecoxib

Severe

Elevated risk of digestive bleeding and kidney problems.

Warfarin

Severe

Higher risk of serious bleeding due to additive effects on clotting.

Mifepristone

Severe

zerodol mr may reduce the effectiveness of mifepristone in medical abortion.

Amiodarone

Severe

Amiodarone may increase tizanidine levels in your body by blocking its breakdown in the liver. This can lead to exaggerated drug effects, such as dizziness, drowsiness, or dangerously low blood pressure.

Methotrexate

Severe

Risk of methotrexate toxicity (bone marrow suppression, liver and kidney damage), especially with reduced kidney function.

Zidovudine

Moderate

Higher risk of blood-related toxicities (e.g., bruising, anemia), especially in HIV+ hemophiliacs.

Levonorgestrel

Moderate

Women taking Levonorgestrel may have 50% slower clearance of tizanidine, meaning it stays longer in the body. This can increase the risk of side effects such as fatigue, weakness, and low blood pressure.

Enalapril

Moderate

Reduced blood pressure-lowering effect. Possible kidney impairment, especially in elderly or dehydrated patients.

Sertraline

Moderate

Elevated risk of gastrointestinal bleeding.

Metformin

Moderate

Can unpredictably alter blood sugar (hypo/hyperglycemia).

Frusemide / Furosemide

Moderate

Decreased diuretic effect and increased risk of kidney toxicity. Risk of high potassium with potassium-sparing types.

Food interactions

There are no specific food or beverage interactions for with Zerodol-MR tablet. It should be taken with or after food to avoid upset stomach.

Frequently asked questions

No, Zerodol-MR and Pan-40 serve different purposes. Zerodol-MR is used for pain and muscle spasms, while Pan-40 is a medicine that reduces stomach acid. Sometimes physicians may prescribe Pan-40 in combination with Zerodol-MR to protect the stomach, but the two are not interchangeable. Do not combine medicines without medical advice.
No, Both Zerodol MR and Hifenac MR are medications used to treat pain and inflammation, but their active ingredients and indications differ.
Yes, Zerodol MR tablet is a painkiller. However, it is not meant for all types of pain.
No, it is usually not recommended to take other painkillers with this medicine, as the risk of stomach inflammation, stomach and intestine bleeding and ulcers increases. Hence, do not take any other painkillers like Ibuprofen, Naproxen, Mefenamic acid, Indomethacin, etc., if you are taking this medicine. Also, remember not to take this medicine if you are allergic or previously had any allergic reactions to other painkillers.
You should take Zerodol MR tablet in dose and duration as prescribed by your doctor. Do not increase the dose on your own. Seek advice from your treating doctor if there is no relief in pain.
Zerodol MR Tablet is a combination of two medicines, Aceclofenac and Tizanidine, whereas the Zerodol SP Tablet is a combination of three medicines, Aceclofenac, Paracetamol and Serratiopeptidase. Both of these medicines are used for different conditions. Take the medicine which is prescribed by your doctor, do not self-medicate.
Yes, it can be used by a diabetic patient. However, Zerodol MR is known to interfere with the action of certain anti-diabetic medicine and can alter your blood sugar levels. Be cautious while using this medicine, frequent glucose monitoring is recommended.
No, Zerodol MR already contains paracetamol. Taking another medicine containing paracetamol can increase the risk of getting side effects.
Yes, components of Zerodol MR tablet can cause dizziness or drowsiness. Hence, it is advised to avoid activities that need the individual to be alert, like driving or operating heavy machinery.
Nausea or vomiting is one of the side effects that can be seen during the treatment, although not everyone gets them. Side effects often improve as your body gets used to the medicine.
Zerodol MR should preferably be taken with food or after food. Taking it with food makes you less likely to get stomach discomfort. You should take it regularly as advised by your doctor.
Zerodol MR starts working within 20-30 minutes of its oral consumption. However, it can vary among individuals depending on their physiology and other biological parameters.
The composition of Zerodol MR consists of a combination of aceclofenac and tizanidine as its active components.
Dryness of mouth is one of the common side effects of Zerodol MR. So, it is advised to drink water regularly or rinse your mouth with water frequently to prevent dry mouth.
Yes, Zerodol MR is used to treat pain and spasm associated with joints and muscles. It relieves pain and inflammation associated with osteoarthritis and rheumatoid arthritis. However, it is advised to take this medicine only if prescribed by the doctor.
Zerodol-MR is a combination medication used to relieve muscle, neck, back, and joint pain, as well as painful muscle spasms. It helps reduce pain, inflammation, and muscle stiffness, which is why it is commonly prescribed for neck strain or cervical pain. It may also provide temporary relief from a toothache when pain is associated with inflammation, but it does not treat the dental cause. For persistent tooth pain, a consultation with a dentist is recommended.
Zerodol-MR is not recommended for children. Giving this medicine to a child without medical supervision can be harmful. If a child has pain or muscle spasms, consult a pediatrician for an age-appropriate alternative.
Zerodol MR Tablet is a combination of two medicines, Aceclofenac and Tizanidine. Zerodol P tablet is a combination of paracetamol and aceclofenac. Zerodol-CR is a controlled-release formulation intended for prolonged pain control, whereas Zerodol-TH is a combination of the non-steroidal anti-inflammatory drug (NSAID) aceclofenac and the muscle relaxant thiocolchicoside. After your diagnosis and assessment of your medical conditions, your doctor shall prescribe you one of these medicines. You should only take medicine as prescribed by your doctor; do not self-medicate.
Zerodol-MR, Nucoxia-MR, Etova-MR, and Intagesic-MR are all used for muscle pain and spasms, but they differ in their pain-relieving component. Myoril mainly acts as a muscle relaxant and may be used in specific cases. The effectiveness varies from person to person, so your doctor will decide the most suitable option based on your medical condition and tolerance.
Zerodol-MR may cause side effects such as stomach discomfort, dizziness, drowsiness, or nausea in some individuals. Avoid alcohol while taking this medicine, as it may increase drowsiness. People with stomach ulcers, liver, kidney, or heart problems should use it cautiously. Always consult your doctor if pain persists or side effects occur.

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Manufacturer Details

Brand: ZERODOL

Manufacturer Name: IPCA LABORATORIES

Address: Ipca Laboratories Ltd.,393/394, Melli. Jorethang Road,,Gom Block, Bharikhola,,South District, Sikkim-737121

Country of Origin: India

Product Fulfillment

Fulfillment Information: Zerodol Mr Strip Of 10 Tablets will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.

In Case of Any Issues Contact Us

Email Id: care@pharmeasy.in

Phone Number: 7666100300

Address: D-37/1, Opp. Sandoz, TTC Industrial Area, MIDC Industrial Area, Turbhe, Navi Mumbai, Maharashtra 400703

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The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please visit to detailed T&C.

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