Ibugesic Plus Tablet
20 Tablet(s) in StripProduct Summary
Ibugesic Plus Tablet is an analgesic, fever-reducing and anti-inflammatory medicine from Cipla used to treat headache, toothache, body ache, muscle or joint pain and fever. It contains ibuprofen 400 mg and paracetamol 325 mg. Both ingredients reduce chemicals involved in pain and fever, while ibuprofen also reduces inflammation.
Medically Reviewed by Dr. Krisha R. Marolia
Last updated on: 13 October 2026 | 9:01 AM (IST)
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Dose Form
TABLET
Expiry
General Information
| Therapy | Analgesic/antipyretic |
| Composition | Ibuprofen(400.0 Mg)+Paracetamol / Acetaminophen(325.0 Mg) Ibuprofen 400.0 Mg+Paracetamol / Acetaminophen 325.0 Mg |
Ibuprofen 400.0 Mg+Paracetamol / Acetaminophen 325.0 Mg

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*Offer applicable on orders above ₹1000About Ibugesic
Ibugesic Plus Tablet is an analgesic and antipyretic medication, widely used for the short-term management of mild to moderate pain, inflammation, and fever. It contains two active ingredients: Ibuprofen (a non-steroidal anti-inflammatory drug, or NSAID) and Paracetamol (Also Known as Acetaminophen). Ibuprofen works by inhibiting the cyclooxygenase (COX) enzymes, which are essential for the production of prostaglandins, a class of chemicals in the body that cause pain, fever, and inflammation. Paracetamol enhances the pain-relieving and fever-reducing effects by acting centrally in the brain, where it blocks the generation of pain signals and regulates body temperature.
This medication is commonly used for conditions such as headaches, toothaches, muscle and joint pain, menstrual cramps, postoperative discomfort, and fever. It is especially beneficial when both pain and inflammation need to be managed simultaneously. Ibugesic Plus provides a faster onset of action and enhanced efficacy compared to either component used alone. However, its use should be limited to the lowest effective dose for the shortest possible duration to avoid adverse effects, particularly gastrointestinal irritation, liver stress, and kidney function compromise.
While Ibugesic Plus is not habit-forming, it should be used with caution in individuals with liver or kidney impairment, gastrointestinal ulcers, bleeding disorders, asthma, cardiovascular conditions, or autoimmune disorders. It is contraindicated in pregnant women (especially during the third trimester), and caution is advised in breastfeeding mothers due to the mild excretion of components into breast milk. Alcohol should be strictly avoided during treatment as it significantly increases the risk of liver toxicity and gastrointestinal bleeding. Ibugesic Plus should not be taken along with other paracetamol-containing products or NSAIDs, unless prescribed by a healthcare provider.
The tablet should be taken with or after food to reduce stomach upset. Dosing should follow your physician's guidance. Using it long-term or at high doses without medical supervision can cause serious problems such as liver failure, kidney damage, or peptic ulcer disease. It may also interact with several medications, including blood thinners (e.g., warfarin), antihypertensives, antiepileptics, antibiotics (e.g., ciprofloxacin), and immunosuppressants (e.g., tacrolimus). Always consult a doctor before starting or combining it with other medications, especially if managing chronic conditions.
Combiflam tablet, Flexon tablet, and Imol Plus tablet also contain the same composition as Ibugesic Plus tablet.
Uses
Contraindications
- If you are allergic to Ibuprofen, Paracetamol, or other Ibugesic Plus tablet ingredients,
- If you have a history of allergic reactions due to painkillers like aspirin, etc.
- If you are taking medicines containing Paracetamol, Ibuprofen, or other pain medicines.
- If you have a history of ulcers or bleeding in the digestive tract.
- If you have an active clotting disorder or disorder related to the blood supply to the brain.
- If you are experiencing fluid loss (due to vomiting, diarrhoea, or not drinking enough fluids).
- If you have a kidney or liver function problem.
- If you are pregnant (last trimester), it should not be given to children under 12 years of age (<40kgs).
Side effects
- Stomach pain
- Diarrhoea
- Vomiting
- Dizziness
- Bloating
- Constipation
- Headache (rare)
- Excessive sweating
- Skin rashes & itching
Precautions and Warnings
Alcohol
UNSAFEYou should avoid consuming alcohol along with this medicine. It can increase the risk of liver disease and stomach bleeding.
Pregnancy
CONTRAINDICATEDPregnant women should not consume this medicine. This medicine can hamper the growth of fetus and can also cause heart and kidney-related problems in the baby. It can delay the labour and increase the duration as both mother and baby are at a risk of bleeding disorders if consumed by pregnant women. Women who are trying to conceive and taking treatment for infertility should not take this medicine.
Breastfeeding
WITH CAUTIONThis medicine passes in breast milk in low concentrations and may not be harmful to the breastfed baby. It can be used for short durations and at lowest possible dose if you are breastfeeding your baby.
Driving
WITH CAUTIONYou may experience dizziness, drowsiness, fatigue and visual disturbances. Thus, it is advised not to drive when you are taking this medicine and experiencing these signs.
Other General Warnings
- You are an older adult.
- You have high blood pressure or heart, kidney or liver diseases.
- You may experience stomach bleeding and ulcers after taking this medicine.
- You have a history of or suffer from asthma & nasal allergy.
- You are suffering from an immune disorder, where your immune system acts against the body tissues.
- You have a hereditary disorder like G6PD deficiency or porphyria (blood disorders).
- You are an alcoholic or recently had major surgery.
- You're trying to conceive; you should discontinue this medicine.
- If you develop skin allergies like rashes, itching, bumps, blisters, etc.
Doctor’s suggestion

Directions for use
Storage and disposal
- Keep this medicine out of the reach of children.
- Store this medicine below 30°C.
Quick tips
- Ibugesic Plus tablet is recommended for short-term use only. Do not take more than the daily prescribed dose, as it may affect the liver or cause allergic reactions.
- You should inform your doctor if you have experienced asthma, rhinitis or hives after taking aspirin or other NSAIDs.
- Before taking this medicine, inform your doctor if you are pregnant, planning on getting pregnant or breastfeeding. Also, inform your doctor about all your medications and medical history.
- Ibugesic Plus tablets should be taken with food to minimize side effects such as stomach discomfort.
- Patients with a history of stomach ulcers, kidney disease, or liver disease should avoid taking them.
Dosage
Overdose
- Taking this medicine in high doses may result in serious liver damage, coma and even death.
- Other symptoms are headache, nausea, vomiting, stomach pain, diarrhoea, unconsciousness, excitement, coma, dizziness, low blood pressure, fits, difficulty in breathing & weight loss.
- If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.
Missed a dose
How Ibugesic works
Interactions
Drug interactions of Ibugesic with other medicine salt
Food interactions
Frequently asked questions
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References
- Zupar [Internet] GSK. 2022 [cited 9 August 2022]
- Nuromol dual action pain relief 200mg/500mg tablets - summary of product characteristics (SmPC) - (EMC). (Accessed: 20 August 2024).
- Derry CJ, Derry S, Moore RA. Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. Cochrane Database Syst Rev. 2013;2013(6):CD010210. Published 2013 Jun 24. doi:10.1002/14651858.CD010210.pub2
- Thybo KH, Hägi-Pedersen D, Dahl JB, et al. Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty: The PANSAID Randomised Clinical Trial. JAMA. 2019;321(6):562-571. doi:10.1001/jama.2018.22039
- Derry, C. J., Derry, S., & Moore, R. A. (2013). Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. The Cochrane database of systematic reviews, 2013(6), CD010210. https://doi.org/10.1002/14651858.CD010210.pub2
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