Dermikem OC Plus Cream
15g Cream in TubeProduct Summary
Dermikem OC Plus Cream, from Alkem Laboratories, contains clobetasol 0.05%, miconazole 2% and neomycin 0.5% for steroid-responsive skin conditions with secondary fungal or bacterial infection. This topical steroid, antifungal and antibiotic combination reduces inflammation through clobetasol, while miconazole and neomycin inhibit susceptible fungi and bacteria.
Medically Reviewed by Dr. Nikita Toshi
Last updated on: 13 October 2026 | 10:09 AM (IST)
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CREAM
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General Information
| Therapy | Topical antimicrobial and steroid |
| Composition | Clobetasol(0.05 %)+Miconazole(2.0 %)+Neomycin(0.5 %) Clobetasol 0.05 %+Miconazole 2.0 %+Neomycin 0.5 % |
Clobetasol 0.05 %+Miconazole 2.0 %+Neomycin 0.5 %

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*Offer applicable on orders above ₹1000About Dermikem
Dermikem OC Plus Cream is a topical medication used to treat inflammation, redness, and swelling caused by bacterial, fungal, or mixed skin infections. It contains three active ingredients: clobetasol, a steroid that reduces inflammation; neomycin, an antibacterial that combats harmful bacteria; and miconazole, an antifungal that treats fungal infections. Together, they offer effective relief from itching, irritation, and infection.
This cream is for external use only. Apply it exactly as prescribed by your doctor and do not use it for any other skin condition without medical advice. Do not apply it on children under two years old. For the best results, complete the full course of treatment even if symptoms improve early. If your condition does not improve, consult your doctor for further assessment.
When applying Dermikem OC Plus Cream, ensure to clean and dry the affected area beforehand. Wash your hands after applying and avoid contact with your eyes, mouth, or healthy skin to prevent spreading the infection. Keeping the area clean and practising good hygiene will promote faster healing.
As with all medicines, this cream may cause mild side effects such as skin irritation, redness, or a burning sensation at the application site. These typically resolve on their own, but if they persist or worsen, seek medical advice. Notify your doctor if you notice severe reactions or any unusual symptoms.
Other creams containing the same combination of clobetasol, neomycin, and miconazole include Lobate GM cream, Clobact GM cream, Sonaderm NM cream, Globet GM cream, and Cosvate NM cream. If you are pregnant, breastfeeding, planning a pregnancy, or have any underlying health conditions, discuss with your doctor before using Dermikem OC Plus Cream to ensure it is safe for you.
Uses
Contraindications
- If you are allergic to clobetasol, neomycin, miconazole or any of the ingredients in Dermikem OC Plus cream.
- Dermikem OC Cream is not supposed to be applied to the face. Do not use the medication for longer than recommended. Do not apply a bandage or dressing to the treated area because it will increase the preparation's absorption and the risk of side effects.
- If you have any untreated skin infections or skin thinning problems.
- You should not use this cream for acne, rashes or skin conditions around your mouth and in the external ear canal.
- You should not use this cream if you have chickenpox, shingles, warts or any other wounds and skin infections.
- Dermikem OC Plus cream should not be used in children below two years of age and for nappy rash.
Side effects
- Burning
- Irritation
- Itching in the area, Dermikem OC Plus cream is applied.
Precautions and Warnings
Alcohol
SAFEThere is no direct interaction between alcohol and Dermikem OC Plus cream. However, you should avoid consuming alcohol as it can worsen the infection and delay healing.
Pregnancy
WITH CAUTIONThere is limited information about the safety of Dermikem OC Plus cream in human pregnancy. In case you are prescribed this cream, avoid using it in larger skin areas for a prolonged duration.
Breastfeeding
WITH CAUTIONDermikem OC Plus cream can be used by a breastfeeding woman if prescribed by the doctor. It should not be applied to the breast or areas near the breast of a breastfeeding mother as there can be chances of ingestion of this by a breastfed infant. Avoid using it on large areas of skin or for a prolonged period.
Driving
SAFEDermikem OC Plus cream is to be applied externally and is less likely to influence your driving ability.
Other General Warnings
- You are experiencing any allergic reactions to the skin after applying the Dermikem OC Plus cream.
- You are experiencing other infections after applying this cream.
- You do not notice any improvement in your condition after using this medicine for a week.
- It would be best not to use this cream for any condition other than those prescribed by your doctor.
- In case you experience any skin reactions after applying this cream, inform your doctor immediately.
- You should not apply the Dermikem OC Plus cream for a prolonged duration on a larger skin area or more than the prescribed duration.
- In case your eyes come in contact with this medicine, rinse your eyes with clean water immediately.
Directions for use
- Use Dermikem OC Plus cream as directed by your doctor and follow all the instructions.
- For external use only. Apply it on a healthy skin surface, free from cuts and wounds.
- Wash your hands before and after using Dermikem OC Plus cream unless your hands are the area to be treated.
- Apply a thin layer and rub gently to cover the affected area, for days and times advised by your doctor.
- If you do not see any improvement in your condition within 7 days, you should consult your doctor.
Storage and disposal
- Store Dermikem OC Plus cream below 25°C, protected from moisture, sunlight and heat.
- Keep this medicine away from children and pets.
- Discard the expired or medicine that is no longer required properly.
Quick tips
- Dermikem OC Plus cream is a topical medication designed to treat inflammation and swelling associated with bacterial, fungal, or mixed skin infections. It treats symptoms such as redness, swelling, and itchiness.
- This cream is strictly for external use and should not be ingested. Use it only as prescribed by your doctor, avoiding overuse or prolonged application beyond the recommended duration.
- Wash your hands before and after applying the cream, and if it accidentally comes into contact with your eyes, rinse them thoroughly with clean water.
- Consult your doctor if you experience any side effects or discomfort while using this medicine. It is not suitable for children under two years of age. Inform your doctor about your medical history and if you are pregnant, planning a pregnancy, or breastfeeding before starting this treatment.
Dosage
Overdose
Missed a dose
How Dermikem works
- During inflammation or infection of the skin, the body releases some chemical substances which make the skin red, itchy and swollen.
- Clobetasol is a steroid which acts by blocking the synthesis of natural substances, i.e. prostaglandins, which are responsible for itching, swelling and redness.
- Miconazole works by inhibiting the formation of a fungal cell wall component, which leads to altered permeability and the growth of fungus, causing infection.
- Neomycin is an antibiotic widely used for treating various bacterial infections of the skin. It works by inhibiting the growth and multiplication of bacteria that cause infection.
- Collectively all these medicines work more effectively by reducing the infection and inflammation of the skin.
Interactions
Drug interactions of Dermikem with other medicine salt
Food interactions
Frequently asked questions
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References
- Dermovate Cream - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 14th Nov 2025]
- Drugs H. Neomycin Topical: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2025 [cited 14th Nov 2025]
- National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 5311051, Clobetasol. 2025 [cited 14th Nov 2025]
- Miconazole [Internet]. ScienceDirect Topics. 2025 [cited 14th Nov 2025]
- Veirup N, Kyriakopoulos C. Neomycin. [Updated 2023 Nov 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan. 2025 [cited 14th Nov 2025]
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