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Zyloric 300 Tablet

10 Tablet(s) in Strip

MRP ₹60.02

₹47.42

21% OFF

₹4.74/tablet (Inclusive of all taxes)
30 days return policy Read More
✱Offer applicable on order above ₹1000

Made by

GLAXOSMITHKLINE

Dosage

TABLET

Expiry

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Product Summary

Uses
Gout
Therapy
Anti-gout
Side effects
Stomach upset, diarrhoea, drowsiness, rashes, vomiting
Salt Content
Allopurinol(300.0 Mg)
3 Step Quality
Assurance
Cash on delivery
available
NPPA
Regulated

Medical Description

Zyloric 300 tablets are used to treat and prevent gout and high uric acid levels caused by kidney problems or certain medications. Zyloric 300 tablets contain the active ingredient allopurinol, which reduces uric acid production in the body.

Gout is a type of arthritis that causes sudden pain, redness and swelling in the joints. This is usually caused by uric acid deposits in the joints. You should not take Zyloric 300 tablets if you have kidney or liver disease, are pregnant or breastfeeding or are allergic to allopurinol. Do not recommend Zyloric 300 tablets to anyone else, even if they have similar symptoms to you.

Before taking Zyloric 300 tablets, tell your doctor about all the medications and herbal supplements you are taking and any medical conditions you have.

Uses

Zyloric 300 tablet is used for the management of gout and increased uric acid levels in the body.

Contraindications

  • If you are allergic to allopurinol or any components of this medicine.
  • If you have liver or kidney function problems or heart failure.
  • If you are pregnant or are breastfeeding.

Side effects

  • An upset stomach
  • Diarrhoea
  • Drowsiness
  • Rashes
  • Vomiting
  • Nausea
  • Allergies
  • Increased thyroid hormone level (TSH)

Precautions and Warnings

Pregnancy

Pregnancy

Zyloric 300 tablet may cause birth abnormalities. Hence, it should not be used in pregnant women. Consult your doctor before starting any medicine during pregnancy.

Breast Feeding

Breast Feeding

Allopurinol passes into the breastmilk and may cause side effects to the baby. Hence, Zyloric 300 tablet should not be used by lactating women.

Driving

Driving

You may experience side effects like drowsiness or dizziness after taking Zyloric 300 tablets. Be cautious while driving if you experience any side effects.

Alcohol

Alcohol

Alcohol increases uric acid levels in the blood and thus increases attacks of Gout. Therefore, avoid alcohol if you have high uric acid levels.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You experience a severe allergic reaction to the skin after taking this medicine (Ulcersin mouth, nose, genitals, rashes and conjunctivitis).
  • You have a liver or kidney function problem.
  • You have high blood pressure or heart problems.
  • You have a malignancy due to which your body is producing extra urate crystals.
  • You may develop a condition called xanthine deposition after using this medicine. However, this can be reduced by maintaining proper hydration.
  • Zyloric 300 tablets can dissolve larger uric acid crystals and can cause impaction in the ureter.
  • Your TSH hormone levels may go high after using Zyloric 300 tablet.

Directions for Use

Take Zyloric 300 tablet with a glass of water. It should be taken with or after meals. Swallow it as a whole. Do not break, cut or chew the tablet. Take it as directed by your doctor and do not consume it more than the prescribed dose.

Storage and disposal

  • Zyloric 300 tablet should be stored at room temperature away from heat and moisture.
  • Keep it out of the reach of children and pets.
  • Do not keep any outdated medicines.

Dosage

Overdose

Symptoms of an overdose may cause gastrointestinal disturbances like nausea, vomiting, stomach pain, diarrhoea and constipation. In case of an overdose, consult your doctor immediately.

Missed a Dose

If you have missed a dosage of Zyloric 300 tablet, take it as soon as you remember. Skip the missed dose if it is almost time for the next dose. A double dose should not be taken to compensate for the missed one.

How does this medicine work?

Allopurinol present in Zyloric 300 tablet inhibits the action of an enzyme Xanthine oxidase. Xanthine oxidase is an enzyme that plays a crucial role in the synthesis of uric acid in the body. Hence, Allopurinol inhibits the production of uric acid and reduces its levels in blood and urine.

Interactions

Interactions with other medicines

  • Sometimes Zyloric 300 tablet may affect the way other medicines work and other medicines may affect how Zyloric 300 tablet works, if taken at the same time.
  • Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interactions.
  • Especially, if you are taking antibiotics such as Ampicillin or Amoxicillin, Anticancer medicines such as Cyclophosphamide, Anti-hypertensive medicines like Captopril, anti-epileptic medicines like phenytoin.
  • Other medicines which are to be used with caution are medicines used for breathing problems like theophylline and immunosuppressants like Cyclosporin.
  • Vidarabine, an antiviral medicine can lead to toxic side effects if taken along and therefore, close monitoring is required.
  • Other anti-gout medicines like probenecid can alter the effect of Zyloric 300 tablet.

Frequently Asked Questions (FAQs)

Zyloric 300 Tablet is used to lower uric acid in the body. It is prescribed for gout where crystals have already deposited, for recurrent kidney stones containing uric acid or calcium oxalate, and to prevent the surge in uric acid that can occur during chemotherapy for blood cancers.
It is not usually started during an acute attack, because any sudden change in uric acid can prolong or worsen it. If you are already taking it when an attack occurs, continue it and treat the attack separately. Stopping and restarting repeatedly is the worst approach.
This is expected. As uric acid falls, crystals already sitting in the joints begin to dissolve and shed, which provokes inflammation. It means the medicine is working, not failing. Your doctor normally prescribes colchicine or an anti-inflammatory for the first few months to cover this period.
Any rash on allopurinol must be taken seriously and reported immediately. Rarely it heralds a severe hypersensitivity reaction with fever, blistering, peeling skin, mouth ulcers, swollen glands and liver or kidney involvement, which can be life-threatening. Stop the medicine and seek urgent medical attention.
Yes. People carrying the HLA-B*5801 gene variant have a much higher risk of severe skin reactions to allopurinol. This variant is considerably more common in people of Han Chinese, Thai and Korean ancestry, and is also present in South Asian populations. Testing is advised in some settings before starting.
Both block the same enzyme, but allopurinol is the long-established first choice with the largest body of evidence, and it is preferred where heart disease is present. Febuxostat is cleared mainly by the liver, so it is often chosen when kidney function is significantly reduced or allopurinol was not tolerated.
Allopurinol and its active breakdown product are cleared by the kidneys. If kidney function is reduced they accumulate, which raises the risk of severe reactions. This is why treatment is started at a low dose and increased slowly, with the target guided by your uric acid level.
Azathioprine and mercaptopurine must not be taken with allopurinol at normal doses. It blocks the enzyme that inactivates them, so they build up to levels causing life-threatening bone marrow suppression. If both are essential, the dose of azathioprine must be cut drastically under specialist supervision.
Uric acid begins falling within a week or two and your doctor will check the level and adjust the dose. Dissolving crystal deposits takes far longer, often a year or more for large tophi, so attacks may continue for a time before becoming less frequent.
Yes, though diet alone rarely controls gout. Reducing beer and spirits, sugary drinks containing fructose, organ meats, red meat and shellfish helps, as does staying well hydrated and maintaining a healthy weight.
Mention kidney or liver disease, high blood pressure, heart disease, thyroid problems, and any previous reaction to allopurinol. Tell your doctor if you are pregnant, planning pregnancy or breastfeeding, and list all your medicines, particularly azathioprine, warfarin and any diuretic.
Take it as soon as you remember unless your next dose is nearly due, in which case skip it. Do not take a double dose. Avoid stopping and restarting repeatedly, as fluctuating uric acid provokes attacks.

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Manufacturer Details

Brand:ZYLORIC

Manufacturer Name:GLAXOSMITHKLINE

Address:Glaxosmithkline Pharmaceuticals Limited. At D:5, M.I.D.C Industrial Area, Paithan 431 148 Dist. Aurangabad

Country of Origin:India

Vendor Details

Fulfillment Information: Zyloric 300 MG Tablet (10) will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.

In Case of Any Issues Contact Us

Email Id:care@pharmeasy.in

Phone Number:7666100300

Address:D-37/1, Opp. Sandoz, TTC Industrial Area, MIDC Industrial Area, Turbhe, Navi Mumbai, Maharashtra 400703

Disclaimer

The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here  for detailed T&C.

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