Allopurinol is a Xanthine Oxidase inhibitor that has its usage in conditions where there are high uric acid levels in the body, such as gout.
Uses of Allopurinol
- Allopurinol is used to treat chronic gout (increased uric acid quantity in the body), uric acid kidney stones.
- In some types of cancer when there is an increase in uric acid (Tumor Lysis syndrome) caused by anticancer medicines.
Contraindications of Allopurinol
When should one not use Allopurinol
Do not take this medicine if you have any allergic reactions to Allopurinol.
Side effects of Allopurinol
Common side effects of this drug are:
- Side effects of Allopurinol may include nausea, diarrhea, joint pain, headache, skin rash, increased liver enzymes or thyroid hormone, depression.
- Severe skin disorders like rash can involve ulcers of the mouth, throat, nose, genitals, and red eyes. Along with this fever, headache, and skin blistering may occur, stop taking Allopurinol and contact your doctor immediately.read less
Precautions and Warnings of Allopurinol
Can I take Allopurinol during pregnancy?
There are no adequate and well-controlled studies regarding the safety of this medicine in pregnant women. Hence it is better to avoid this medicine in pregnancy. Consult your doctor for further advice.
Can I take Allopurinol while breastfeeding?
Allopurinol is known to pass in human breast milk. It is not recommended to take this medicine during breastfeeding.
Can I drive if I have consumed Allopurinol?
Allopurinol may make some people feel dazed or giddy. Do not drive if you have any of these.
Can I consume alcohol with Allopurinol?
There is no known interaction between alcohol and aAllopurinol. But alcohol can increase uric acid levels in the body and worsen your underlying disease.
Other General Warnings
Talk to your doctor if
- You have kidney or liver problems
- You suffer from high blood pressure or have heart problems
- You take medicines like Diuretics or ACE-inhibitors
- You have thyroid problems
- Take special care, just in case you have kidney stones, the kidney stones may become smaller and may enter your urinary tract, drink lots of water
Mode of Action of Allopurinol
How Does It Work?
Allopurinol belongs to a bunch of medicines known as catalyst inhibitors. These medicines inhibit the amount of uric acid production in your body.
Interactions of Allopurinol
Interactions with other medicines
- Azathioprine and 6-Mercaptopurine
- Warfarin (reported rarely, but is dangerous when it occurs)
- Chlorpropamide ( used to treat diabetes)
- Cyclophosphamide, Doxorubicin, Bleomycin, Procarbazine, Mechlorethamine
- Ampicillin and Amoxicillin
- Diuretics, in particular, Thiazides, especially in renal impairment
- Angiotensin-Converting-Enzyme inhibitors (ACE- inhibitors like Captopril)
Interactions with food items
There are not many specific interactions of this medicine with food. You are advised to maintain the right amount of water intake while on this treatment.
Dietary Restrictions of Allopurinol
No information is available on dietary restrictions while you are taking Allopurinol, consult your doctor or pharmacist for further details.
Dosage of Allopurinol
Overdose symptoms may include dizziness, nausea, vomiting, rash , headache, etc. Seek emergency medical care immediately.
Missed a Dose
If you missed any dose, take it as soon as you remember. However, if it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to compensate for a missed dose.
Frequently Asked Questions (FAQs)
Q: What should I consult with my doctor before taking this medicine?
A: Discuss with your doctor all your other medical problems along with other medicine consumed by you, before starting on this medicine. Inform your doctor if you are pregnant or a breastfeeding mother.
- Ema.allopurinol. [Accessed 13.Jun.2019] (online)
- Yamanaka H. Alcohol ingestion and hyperuricaemia. Nippon Rinsho. 1996;54(12):3369–3379. [PubMed] [Google Scholar] Dailymed.allopurinol. [Accessed 13.Jun.2019] (online)
- Lactmed.allopurinol. [Accessed 13.Jun.2019] (online) Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Allopurinol. [Updated 2018 Oct 31].
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)
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