Zejula 100Mg Bottle Of 56 Tablets

• Maintenance treatment of adults with advanced high-grade ovarian, fallopian tube, or primary peritoneal cancer who have achieved a complete or partial response following first-line platinum-based chemotherapy.
• Maintenance treatment of adults with platinum-sensitive, relapsed high-grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer who have achieved a complete or partial response to platinum-based chemotherapy.

• Very Common
• Nausea and vomiting
• Low platelet count (thrombocytopenia – leads to easy bruising/bleeding)
• Low red blood cell count (anemia – causes tiredness and breathlessness)
• Low white blood cell count (neutropenia/leukopenia – increases infection risk)
• Fatigue, weakness, and insomnia
• Loss of appetite and abdominal pain
• Constipation
• Muscle, back, or head pain
• Shortness of breath and skin rash
• Other Common Side Effects
• Diarrhea and taste changes
• High blood pressure (hypertension)
• Cough and urinary tract infections
• Acute kidney injury and low blood magnesium
• Serious Side Effects (Seek Immediate Medical Care)
• MDS / AML: Rare, potentially fatal bone marrow disorders (Myelodysplastic Syndrome / Acute Myeloid Leukemia). Symptoms include persistent fever, severe fatigue, frequent infections, or unexplained bleeding.
• Severe Bone Marrow Suppression (Pancytopenia): Severe reductions in blood cell counts.
• Hypertensive Crisis: Severely elevated blood pressure.
• PRES (Posterior Reversible Encephalopathy Syndrome): Rare brain disorder causing severe headaches, seizures, vision loss, or confusion.
• Pneumonitis: Non-infectious lung inflammation.

Other General Warnings

• Develop persistent fever, severe weakness, or unexplained bruising (potential signs of MDS/AML or severe bone marrow suppression).
• Experience significant spikes in blood pressure or heart rate.
• Develop sudden, severe headaches, vision changes, or confusion (signs of PRES).
• Have heart problems or high blood pressure.
• Have liver problems, as dose adjustment may be required in moderate hepatic impairment.

• Take Zejula tablet once daily by mouth at roughly the same time every day.
• Swallow tablets whole; do not chew, crush, or split.
• You may take it with or without food. Taking your dose at bedtime can help reduce nausea.
• Your initial dose depends on your body weight and baseline blood counts. Always follow your doctor’s prescribed dosage.

• Taking your tablet at bedtime can help reduce nausea.
• Keep all scheduled weekly and monthly blood test appointments; they are essential for monitoring your bone marrow safety.
• Monitor your blood pressure regularly at home or at your local clinic.
• Women must use effective birth control during treatment and for several months after the last dose.
• Do not breastfeed during treatment and for a few months after the final dose.

Overdose

Missed a Dose

• If you miss a dose, skip it and take your next dose at the regularly scheduled time. Do not take extra tablets to make up for a missed dose.
• If you vomit after taking a tablet, do not take an extra dose; take your next scheduled dose as usual.

• Niraparib inhibits PARP-1 and PARP-2 enzymes involved in DNA repair. By inhibiting PARP activity and increasing PARP–DNA complex formation, niraparib promotes DNA damage, which can lead to apoptosis and cancer cell death.
• Niraparib has shown cytotoxic effects in cancer cells with or without BRCA1/2 deficiencies and anti-tumour activity in preclinical models with BRCA1/2 mutations or homologous recombination deficiency (HRD).

Interactions with other medicines

• Niraparib may affect how some medicines are transported and processed in the body. Tell your doctor about all prescription medicines, over-the-counter medicines, vitamins and herbal supplements you take before starting niraparib.
• Niraparib is not significantly broken down by an enzyme called CYP3A4, so interactions involving this enzyme are not expected to be significant.
• Blood pressure medicines: Niraparib can increase blood pressure. Your doctor may check your blood pressure regularly and adjust your blood pressure medicine if needed.

Interactions with food items

• No specific interactions have been reported.
• Try to avoid alcohol during treatment to prevent worsening fatigue, dizziness, and nausea.
• Drink adequate fluids daily to support your kidneys and overall health.