Tuccatinn 50Mg Bottle Of 60 Tablets

• Tuccatinn tablet is used in combination with trastuzumab and capecitabine to treat adults with advanced HER2-positive breast cancer that cannot be removed by surgery or has spread to other parts of the body, including the brain.
• It is used in patients who have previously received one or more HER2-targeted treatments for metastatic breast cancer.

• Diarrhoea, which can be severe and may require prompt medical management
• Hand-foot syndrome (palmar-plantar erythrodysesthesia), causing redness, pain, swelling and blistering on the palms and soles
• Nausea
• Vomiting
• Liver enzyme abnormalities (hepatotoxicity)
• Mouth sores (stomatitis)
• Decreased appetite
• Low red blood cell count (anaemia), causing tiredness and breathlessness
• Skin rash
• Fatigue and weakness
• Abdominal pain
• Fever (pyrexia)
• Infusion-related reactions (related to trastuzumab)
• Joint pain (arthralgia) and muscle pain
• Peripheral neuropathy, causing numbness or tingling in the hands and feet
• Weight loss
• Nosebleeds (epistaxis)
• Raised creatinine levels in blood tests
• High blood pressure (hypertension)
• Back pain
• Cough and shortness of breath
• Chills
• Constipation
• Anxiety

Other General Warnings

• You develop severe or persistent diarrhoea, as it can cause dehydration and kidney problems and may require interrupting treatment or adjusting the dose.
• You notice signs of liver problems, such as yellowing of the skin or eyes, dark urine, severe tiredness, loss of appetite, or upper abdominal pain.
• You have severe liver impairment (Child-Pugh C), as a dose reduction is required.
• You develop signs of dehydration, such as excessive thirst, dark urine, dizziness, or rapid heartbeat.
• You take strong CYP3A or moderate CYP2C8 inducers, or strong CYP2C8 inhibitors, as these may alter tucatinib levels and increase the risk of side effects.
• You take sensitive CYP3A substrates, as tucatinib may increase their blood levels and adverse effects.
• You are planning to have children, as the potential effects on fertility should be discussed with your doctor.

• Take Tuccatinn tablet exactly as your doctor prescribed.
• Swallow it whole with water; do not chew, crush, or split it, and do not take broken, cracked, or damaged tablet.
• Tuccatinn tablet can be taken with or without food.
• Keep Tuccatinn tablet in its original container with the desiccant packet and discard any unused tablets 3 months after opening the bottle.

• Store at room temperature, 20-25°C (68-77°F), in the original container to protect from moisture; keep the desiccant packet in the bottle and replace the cap tightly after each use.
• Do not freeze.
• Discard any unused tablets 3 months after opening the bottle and keep out of reach of children and pets.

• Never crush, chew, or split the tablets; swallow them whole, and do not take a tablet that is broken or cracked.
• Contact your doctor immediately if you develop severe or worsening diarrhoea, as it can lead to dehydration and other complications.
• Tell your doctor right away if you develop yellowing of the skin or eyes, dark urine, extreme tiredness, or pain in the upper right abdomen, as these may signal serious liver damage.
• Keep the desiccant packet in the original bottle and discard any unused tablets 3 months after opening the bottle.
• Women of childbearing potential must use effective contraception during treatment and for 1 week after the last dose; men with female partners of childbearing potential must also use contraception during treatment and for 1 week after the last dose.
• Inform all your doctors, dentists, and emergency care providers that you are taking Tuccatinn tablet, as it can interact with many other medicines.

Overdose

• There is no specific antidote for a Tuccatinn tablet overdose. The side effects seen in an overdose are expected to be similar to or more severe than those already described, particularly diarrhoea and liver enzyme abnormalities. If you think you have taken too much of this medicine, contact your doctor or go to the nearest emergency department right away.
• Since Tuccatinn tablet is taken at home, always keep it in its original container and never share it with others.

Missed a Dose

• If you miss a dose of Tuccatinn tablet or vomit after taking a dose, do not take an extra tablet. Simply take your next dose at its regular scheduled time and continue as planned.
• Do not take double doses to make up for a missed one. If you are unsure what to do, contact your doctor or pharmacist for advice.

Interactions with other medicines

• Strong CYP3A or moderate CYP2C8 inducers (e.g., rifampicin) may reduce tucatinib levels and effectiveness, so avoid them.
• Strong CYP2C8 inhibitors (e.g., gemfibrozil) may increase tucatinib levels and side effects, so you may need to adjust the dose.
• Tucatinib may increase levels of sensitive CYP3A substrates; you may need to adjust the dose of the other medicine.
• Tucatinib may increase levels of P-glycoprotein (P-gp) substrates, such as digoxin, so monitoring or dose adjustment may be needed.
• Tell your doctor about all prescription and OTC medicines, vitamins, supplements, and herbal products you take before starting treatment.

Interactions with food items

• Tuccatinn tablet can be taken with or without food.
• Eating small, light, and frequent meals can help manage nausea, vomiting, and diarrhoea, which are reported side effects.
• Drink enough water and fluids throughout the day to help prevent dehydration, particularly if diarrhoea develops.
• Avoid alcohol during treatment, as it can worsen diarrhoea, fatigue, and may add to liver-related concerns.