ROKO Capsule

• If you are known to have an allergy to the Roko capsule or any other ingredient of Roko capsule.
• If your age is less than 9-years.
• If you already suffer from constipation or develop it during treatment with the medicine.
• If there is unexplained swelling of the stomach during or before treatment, which does not get relieved on its own.
• If you suffer from diarrhoea with blood in stools or have a high fever.
• If you are a known case of or appear to have symptoms of ulcerative colitis (like stomach pain or cramps, weight loss, fatigue), which is a chronic disease of the gut.
• If you suffer from diarrhoea due to infection caused by bacteria like Salmonella, Shigella or Campylobacter.
• If you suffer from diarrhoea due to the use of broad-spectrum antibiotics like Amoxicillin, Ampicillin, Cephalosporins like Cefixime, Clindamycin, etc.

• Headache
• Dizziness
• Nausea
• Vomiting
• Dryness of mouth
• Constipation
• increased gas formation
• Indigestion
• Stomach pain or discomfort

Other General Warnings

• You are suffering from acute diarrhoea, you must pay keen attention to appropriate fluid and electrolyte replacement from time to time.
• You are suffering from diarrhoea for many days, do not keep taking Roko capsule endlessly. Instead, get yourself checked as long-term diarrhoea may be a symptom of some serious underlying disease.
• You are suffering from diarrhoea for more than 48 hours and Roko capsule does not control it, please consult a doctor for further treatment.
• You are an AIDS patient suffering from diarrhoea, you must stop taking tablets at the first sign of stomach distension (bloating and swelling of the belly). The chances of painful constipation and intestinal obstruction are much higher in AIDS patients suffering from intestinal infections.
• You are suffering from liver disease, Roko capsule should be used with caution. It is important to watch out for dizziness, drowsiness and mental confusion.
• You are suffering from rare hereditary conditions in which your body cannot handle certain sugars (galactose intolerance, lactase deficiency or glucose-galactose malabsorption).
• This medicine should be used cautiously in children and patients on a low-sodium diet.
• This medicine should be discontinued promptly if signs of constipation, stomach distension or stomach pain develop.
• You should not exceed the recommended dose or duration of treatment as it is associated with increased heart disorders.

• Take Roko capsule as a whole with a sufficient amount of water.
• You should take this medicine as directed by your doctor.
• You should not consume it more than that prescribed by your doctor.

• Roko capsule does not require any requirements for storage.
• Keep out of the reach and sight of children and pets.
• Refer to the carton for the expiry date. You should not use this medicine once the expiry date has passed. The expiry date refers to the last day of that month.
• You should not flush this medicine in the toilet or pour them into the drain. You need to properly discard this medicine when it is expired or no longer needed.

• Do not use it if there is blood or mucus in the stool, or a high fever. In dysentery and some bowel infections, slowing the bowel traps the infection and can cause serious complications.
• Fluids come first. Oral rehydration solution replaces what is being lost and is what prevents harm; this capsule only slows the bowel.
• Stop as soon as the stools firm up, and never exceed the prescribed amount. Taking more than the recommended dose can cause dangerous heart rhythm disturbances.
• See a doctor rather than continuing if diarrhoea lasts more than about two days, or if there is severe abdominal pain, persistent vomiting, or signs of dehydration such as passing very little urine.

Overdose

• Excess of Roko capsule will lead to abnormalities of the rhythm of the heart and respiratory failure.
• Symptoms of overdose are palpitations, difficulty breathing, choking or vomiting while not being fully conscious, coordination abnormality, sleepiness, constipation.
• If you experience any of the symptoms or think you have taken too much of this medicine, contact your doctor or visit the nearest hospital immediately.

Missed a Dose

• Missing a dose of this medicine may reduce the effectiveness of the treatment.
• If you missed any dose of medicine, then take it as soon as you remember. If it is time for your next dose, then skip the missed dose and continue with your regular dose schedule. Do not take a double dose of medicine to compensate for the missed one.

Interactions with other medicines

• If you take Roko capsule with Ritonavir (used to treat AIDS), Quinidine (used to treat malaria and for disorders affecting the heart rate), Itraconazole; Ketoconazole, (used to treat fungal infections), Gemfibrozil (used to reduce cholesterol in blood) or with an oral preparation of desmopressin, which is a medicine given for excessive urination, they will increase the amount of Roko capsule in blood by slowing its systemic breakdown thereby requiring adjustment of doses by your treating physician.
• You should avoid this medicine in combination with medicines known to cause ECG changes e.g. Quinidine (medicines given for malaria and for disorders affecting the heart rate), Procainamide, Amiodarone, Sotalol, (medicine given for disorders affecting the heart rate), Chlorpromazine, Haloperidol, Thioridazine, Ziprasidone, (medicines given for psychosis), Moxifloxacin (an antibiotic), Pentamidine (an antimicrobial) and Methadone (a pain killer).
• If you are currently taking any one or more of the following medicines, then it is advisable to inform the treating physician in advance and confirm whether it is safe to continue or start treatment with Loperamide. Certain pain killers like Hydrocodone, Oxycodone, Tramadol, Fentanyl, Tapenade, anti-allergy medicines like Hydroxyzine, Promethazine, Phenyltoloxamine, Orphenadrine and Tripelennamine; anti-dizziness medicines like Hyoscine, Dimenhydrinate, certain anti-asthma medicines like oral preparations of Ipratropium, Tiotropium, etc. These medicines decrease the movement of the intestine and may cause constipation if used with the Loperamide tablet.

Interactions with food items