Progynova 2mg Tablet
Description
Progynova 2 contains estradiol as its active ingredient, a semi-synthetic form of the female hormone estrogen. This medicine is primarily used as Hormone Replacement Therapy (HRT) to manage estrogen deficiency in women who are peri- or postmenopausal. Replenishing the reduced estrogen levels in the body helps alleviate associated symptoms. It is also prescribed to reduce the risk of osteoporosis and fractures in postmenopausal women who are susceptible to these conditions. It works by binding to estrogen receptors, which has a beneficial effect on bone density and helps to inhibit bone degradation associated with osteoporosis.
It is crucial that you take Progynova 2 exactly as directed by your doctor, for the full prescribed duration, and never stop taking it on your own, even if you begin to feel better, as this could lead to treatment failure. You can take this medicine with or without food, but it is advised to avoid grapefruit juice, as it may interfere with the medicine's metabolism and increase the risk of side effects. Before starting this treatment, you must inform your doctor about your complete medical history, especially if you have had a history of breast cancer, undiagnosed abnormal vaginal bleeding, liver or kidney problems, blood clotting disorders, or certain heart-related conditions, as these are contraindications for its use.
Progynova 2 should not be used if you are pregnant, think you may be pregnant, are planning a pregnancy, or are breastfeeding. If pregnancy is detected while you are on this medicine, you should stop taking it immediately and inform your doctor. You should avoid smoking while taking Progynova 2 as it can cause serious effects. Do not consume alcohol with this medicine, as it may alter its effectiveness. If you consume alcohol often, you should discuss this with your doctor. Some medicines, including those for fits like phenytoin, anti-infective medicines like rifampicin, and even herbal products like St. John's wort, can decrease the effect of Progynova 2, while anti-fungal medicines like fluconazole may increase the risk of side effects.
While generally well-tolerated, some common, usually mild side effects you may experience include headache, migraine, altered mood, dizziness, fatigue, skin rash, or palpitations. If you experience severe side effects or symptoms of an overdose, such as nausea and vomiting, you should contact your doctor immediately. If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed one and continue your regular schedule; do not double the dose. You should also be aware that this medicine may increase the risk of certain health problems like blood clots, stroke, and breast cancer. Talk to your doctor about your individual risk factors before starting this medicine.
Evatone tablet, EV tablet, and Endofert tablet are other medicines with estradiol as their active ingredient.
Product Summary
| Offer Price | ₹431.16 |
| You Save | ₹159.47 (27% on MRP) |
| Contains | Estradiol Valerate(2.0 Mg) |
| Uses | Hormonal replacement therapy (HRT) |
| Side effects | Headache, migraine, altered mood, altered weight |
| Therapy | HORMONE REPLACEMENT THERAPY |
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Uses
- Progynova 2 tablet is used to treat oestrogen deficiency in peri and postmenopausal women as a hormone replacement therapy (HRT).
- It is also used to reduce the risk of osteoporosis and fractures.
Contraindications
- If you are allergic to estradiol or any of the other ingredients of the Progynova 2 tablet.
- If you had a history of or have breast cancer.
- If you have undiagnosed abnormal vaginal bleeding.
- If you had a history of or are suspected to have oestrogen-dependent tumours such as endometrial cancer.
- If you have untreated thickening of the endometrial lining.
- If you have or had a severe liver or renal problem.
- If you had or have any blood clotting disorder of veins such as venous thromboembolism.
- If you have any heart-related conditions such as chest pain due to blockage in arteries (myocardial infarction, angina).
- If you have-blood related disorders such as porphyria, protein C, and protein S deficiency.
Side effects
- Headache
- Migraine
- Altered mood
- Increased or decreased weight
- Increased appetite
- Visual disturbance
- Dizziness
- Fatigue
- Skin rash
- Palpitations
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You experience or have a thickening of the endometrium.
- You have liver, kidney, thyroid or heart-related problems.
- You have bleeding or clotting disorder.
- You have high blood pressure, diabetes, asthma, fits, and thickening of ear tissue.
- You have a risk of cancer such as the breast or the endometrium.
- You have allergic conditions such as systemic lupus erythematosus (SLE).
- You have a severe headache or migraine.
- You had or have decreased blood supply to the brain (stroke).
- You experience fluid retention in the body.
- You have a high lipid level in the body.
Directions for Use
- Take Progynova 2 as a whole with a sufficient amount of water, with or without food.
- You should take this medicine regularly and without fail as directed by your doctor.
Storage and disposal
- Store Progynova 2 tablets below 25°C in a clean and dry place, protected from moisture, sunlight and heat.
- Keep the medicine away from children and pets.
Quick Tips
- Progynova 2 tablet is used to treat oestrogen deficiency in peri and postmenopausal women.
- It is also used to reduce the risk of osteoporosis and fractures.
- Take this tablet as advised by your doctor for the prescribed duration.
- Inform your doctor about any medical conditions or medications you are taking before starting Progynova tablet.
- This medicine may increase the risk of certain health problems like blood clots, stroke, and breast cancer. Talk to your doctor about your individual risk factors before starting this medicine.
- Do not take this medicine if you are pregnant, planning on becoming pregnant, or breastfeeding.
- Do not consume alcohol with Progynova 2 tablet, as it may alter the effectiveness of this medicine
Dosage
Overdose
Missed a Dose
Mode of Action
How Does It Work?
Interactions
Interactions with other medicines
- Some medicines may alter the effect of Progynova 2 tablet, or this medicine may alter the effect of other medicines.
- Concomitant use of Progynova 2 and anti-epileptic medicines like phenytoin, primidone, anti-infective medicines like rifampicin, rifabutin, and herbal products like St. John's wort can decrease the effect of Progynova 2 tablet....
- Anti-HIV medicines like saquinavir, indinavir, etc, when used with Progynova 2 tablet, can interfere with the effect of this medicine.
- Anti-fungal medicines like fluconazole and itraconazole may increase the effect of Progynova 2 tablets and increase the risk of side effects.
Interactions with food items
Content Details
Dr. Arpit Verma
MBBS, MD, CCEBDM Diabetology
Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: Can I stop taking Progynova 2mg tablet on my own?
Q: Is it fine if I occasionally smoke while taking Progynova 2mg tablet?
Q: What is Progynova 2mg used for?
Q: How does Progynova work?
Q: Can you drink while taking Progynova?
Q: What are the side effects of Progynova?
References
- ESTROBUILD Tablet [Internet]. Torrentian.com. 2025 [cited 27th Oct 2025]
- How Alcohol Affects Women’s Hormones, Before and After Menopause [Internet]. Ria Health. 2025 [cited 27th Oct 2025]
- DrugBank. Estradiol valerate. 2025 [cited 27th Oct 2025]
- National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 13791, Estradiol Valerate. 2025 [cited 27th Oct 2025]
- DailyMed. ESTRADIOL VALERATE injection. 2025 [cited 27th Oct 2025]
- ScienceDirect. Estradiol valerate. 2025 [cited 27th Oct 2025]
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