Lorbriqua 100Mg Strip Of 10 Tablets (Pack Of 3)

• If you have a known hypersensitivity or severe allergic reaction to lorlatinib or any of the inactive ingredients in the tablet formulation.
• With strong CYP3A inducers, such as rifampicin, as they can significantly reduce lorlatinib levels and may reduce its effectiveness.
• During pregnancy unless specifically considered necessary by your doctor.
• Breastfeeding should be avoided during treatment and for the recommended period after the final dose.

• High cholesterol and triglyceride levels
• Edema (swelling, particularly in the hands, ankles, or feet)
• Peripheral neuropathy (numbness, tingling, or pain in the hands and feet)
• Cognitive effects (such as memory loss, confusion, or difficulty speaking)
• Fatigue and weakness
• Weight gain and joint pain

• Diarrhea and nausea
• Mood changes (including anxiety, depression, or irritability)
• High blood pressure
• Headache and dizziness
• Skin rash

• Severe cognitive or psychiatric effects (such as severe depression, hallucinations, or suicidal thoughts)
• Heart rhythm abnormalities, including atrioventricular block and PR-interval prolongation
• Pancreatitis (severe abdominal pain)
• Interstitial lung disease (severe breathing difficulties or cough)
• Significant liver enzyme elevations

Other General Warnings

• You notice new or worsening mood changes, personality shifts, or difficulty speaking/thinking.
• You experience signs of a heart rhythm problem, such as fainting, dizziness, or an abnormal heartbeat.
• You develop a new or worsening cough or shortness of breath.
• You have a history of liver disease or heart rhythm problems.
• You develop significant swelling, weight gain, or high blood pressure.
• Your cholesterol or triglyceride levels become elevated.

• Take Lorbriqua tablet orally exactly as prescribed by your doctor, once daily at the same time each day.
• Swallow the tablets whole with a glass of water; do not crush, split, or chew them.
• You may take this medication either with or without food.
• Continue your treatment until disease progression or unacceptable toxicity, as determined by your doctor.

• Store the tablets at room temperature, according to the product's storage instructions.
• Keep the medication container tightly closed and out of the reach of children and pets.
• Return any unused or expired tablets to your pharmacist for safe disposal.

• Keep all scheduled blood test appointments to monitor your cholesterol, triglycerides, liver function, blood pressure, and general health.
• Report any changes in your speech, memory, mood, or ability to focus to your doctor immediately.
• Your doctor may prescribe treatment to control increased cholesterol or triglyceride levels.
• Tell your healthcare providers you are taking this medication before any surgery or dental work.
• Contact your doctor right away if you develop a new or worsening cough or shortness of breath.
• Use effective contraception as advised by your doctor.

Overdose

• If you think you have taken more Lorbriqua tablet than prescribed, contact your doctor or seek emergency medical attention immediately.
• Treatment of overdose is supportive, as there is no specific antidote.

Missed a Dose

• If you miss a dose of Lorbriqua tablet, take it as soon as you remember, unless it is close to your next scheduled dose.
• Never take a double dose to make up for a missed dose.

Interactions with other medicines

• Avoid strong CYP3A inducers (such as rifampicin, carbamazepine, or St. John's wort), as they can significantly reduce blood levels and effectiveness of the medication.
• Strong CYP3A inhibitors (such as ketoconazole, clarithromycin, or ritonavir) can increase lorlatinib levels. If a strong CYP3A inhibitor cannot be avoided, your doctor may need to adjust the dose and monitor you closely.
• Inform your doctor about all prescription drugs, over-the-counter medicines, and herbal supplements you are taking, especially those that may affect your heart rhythm or liver.

Interactions with food items

• Lorbriqua tablet may be taken with or without food.
• Avoid grapefruit and grapefruit juice, as they may increase lorlatinib levels.
• Maintain a balanced diet and stay adequately hydrated throughout treatment.