Foiri 40Mg Vial Of 2Ml Injection

• If you have a known hypersensitivity or severe allergic reaction to irinotecan hydrochloride trihydrate or any of the inactive excipients.
• If you have a chronic inflammatory bowel disease and/or a bowel obstruction.
• If you have severe bone marrow failure.
• If you have significantly elevated baseline bilirubin levels (more than 3 times the upper limit of normal, indicating severe liver issues).
• If you are pregnant or breastfeeding.
• If you have a severe decline in your general health and physical ability to perform daily activities (classified by doctors as a poor performance status).

• Late diarrhea (occurring more than 24 hours after infusion, which can be severe and dehydrating)
• Bone marrow suppression leading to neutropenia (low white blood cell count increasing infection risk), anemia, and thrombocytopenia
• Nausea, vomiting, and loss of appetite
• Temporary hair loss (alopecia)
• Asthenia (weakness) and fatigue

Other General Warnings

• You experience severe, prolonged diarrhea (especially if it begins more than 24 hours after your infusion), as this requires immediate medical attention and aggressive hydration.
• You develop a fever, chills, or signs of infection while your blood counts are low.
• You experience sudden shortness of breath, cough, or breathing difficulties.
• You have a history of Gilbert's syndrome, as specialized monitoring is required.

• Foiri injection is always prepared and administered by a trained healthcare professional as an intravenous infusion in a hospital or clinic.
• Do not attempt to self-administer or prepare this medication at home.
• Ensure proper hydration and follow all pre-medication instructions (such as receiving antiemetics or atropine if needed for cholinergic symptoms) provided by your care team.
• Keep all scheduled appointments for your treatment cycles, blood tests, and clinical evaluations.

• Hospital pharmacies and clinical staff handle storage of Foiri injection vials strictly according to pharmaceutical guidelines (typically stored at controlled room temperature, protected from light).
• Keep out of the reach of children and pets in a secure medical environment.
• Clinical staff must properly dispose of vials, infusion bags, and administration equipment in accordance with hospital biomedical waste protocols.

• Keep all scheduled blood test appointments so your doctor can check your white blood cell counts and liver function before every cycle.
• Ensure you have your prescribed anti-diarrheal medication at home before your infusion begins, and know exactly how to use it at the very first sign of late diarrhea.
• Report any fever, chills, dizziness, or persistent diarrhea to your medical team immediately.
• Watch for early cholinergic symptoms during your infusion (like excessive sweating or abdominal cramps) and notify your nurse right away so they can treat it.
• Inform all your healthcare providers that you are taking this medication before undergoing any other medical procedures or dental work.

Overdose

• If an overdose is suspected, emergency medical intervention must be initiated immediately in a hospital setting.
• Symptoms of an overdose can include severe myelosuppression, profound neutropenia, and severe gastrointestinal complications.
• Management involves supportive hospital care, growth factor administration, aggressive anti-diarrheal protocols, and close clinical monitoring.

Missed a Dose

• If you miss a scheduled infusion appointment, contact your hospital or oncology clinic immediately to reschedule.
• Do not try to make up a missed session on your own, as your doctor will safely adjust your treatment schedule based on your blood counts and recovery status.

Interactions with other medicines

• Avoid St. John's wort (a herbal supplement), as it can significantly decrease irinotecan blood levels and effectiveness.
• Avoid live or attenuated vaccines during treatment and for several months afterward due to immunosuppression.
• Inform your doctor about all prescription drugs, over-the-counter medicines, and herbal supplements you are taking, especially strong CYP3A4 inhibitors (e.g., ketoconazole) or inducers (e.g., rifampicin, anticonvulsants) which alter drug clearance.
• Use caution with neuromuscular blocking agents, as irinotecan can prolong their activity.

Interactions with food items