Farabine 20 Mg Injection 1

• Acute lymphoblastic leukaemia (ALL) in paediatric patients who have relapsed or are refractory after receiving at least two prior regimens, and where no other treatment option is anticipated to result in a durable response.

• If you are allergic to clofarabine or any other components of the injection.

• Vomiting
• Nausea
• Diarrhoea
• Fever with a low white cell count (febrile neutropenia)
• Itching
• Headache
• Bacteria in the bloodstream (bacteremia)
• Fever
• Rash
• Fast heartbeat
• Abdominal pain
• Chills
• Tiredness
• Loss of appetite

Other General Warnings

• You have any kidney or liver problem, or have had one in the past.
• You have an infection now, or you develop fever, chills or a sore throat during treatment.
• You notice unusual bruising or bleeding, including nosebleeds or blood in the stool or urine.
• You are passing much less urine than usual, or your legs swell.
• You notice yellowing of the skin or eyes, or dark urine.
• You develop a widespread rash, or skin that blisters or peels.
• You are pregnant or planning a pregnancy, as this medicine can harm an unborn baby.
• You could become pregnant, as effective contraception is needed during treatment and for a period afterwards that your doctor will specify.
• You are breastfeeding, as breastfeeding is not advised during treatment or for a period after the last dose.
• You are taking any other medicine, particularly one that affects the kidneys.

• Farabine 20 Injection is given in hospital by a doctor or nurse experienced in cancer treatment.
• It is given as an infusion into a vein, in doses and treatment cycle fixed by your doctor.
• The dose, the number of treatment days and the interval between cycles are decided by your doctor.
• Fluids are usually given through the drip to protect the kidneys, and you may give other medicines to reduce the risk of complications.
• Blood counts and kidney and liver function are checked regularly during treatment.
• Never try to change, delay or skip a treatment on your own.

• Farabine 20 Injection is a hospital-administered medicine, so the pharmacy handles its storage, preparation and disposal.
• Store at 20 to 25 degrees Celsius, in the original carton.
• Do not freeze it.
• Keep it out of the reach of children.
• Do not use it after the expiry date printed on the pack.
• Unused product and waste are disposed of by the hospital in line with local requirements for cytotoxic medicines. Do not dispose of it yourself.

• Report fever, chills or a sore throat immediately. With low white cell counts an infection can become serious very quickly, and this is the single most important thing to act on.
• Tell the team about unusual bruising, nosebleeds, blood in the stool or urine, or a headache that will not settle.
• Drink fluids as your team advises. Good hydration helps protect the kidneys during treatment.
• Report a drop in how much urine you are passing, or swelling of the legs.
• Report yellowing of the skin or eyes, dark urine or pain over the upper right abdomen.
• Tell your doctor at once about a widespread rash, or skin that blisters or peels.

Overdose

Missed a Dose

Interactions with other medicines

• Tell your doctor about every medicine you take, over the counter medicines, herbal products and supplements.

Interactions with food items

• Farabine 20 Injection is given into a vein in hospital, so interactions with food do not apply.