Bixiva 5Mg Strip Of 10 Tablets

• Chronic constipation in adults, excluding constipation caused by an underlying structural problem such as a bowel obstruction, tumour, or hernia

• If you are allergic to elobixibat or any other ingredient in this medicine, as a serious allergic reaction may occur
• If you have a confirmed or suspected blockage in the intestine caused by a tumour or hernia, as this medicine may make the blockage worse

• Headache and dizziness
• Hot flushes
• Nausea
• Upper abdominal pain and general abdominal discomfort
• Softer stools than usual
• Raised liver enzyme levels (ALT, AST) in blood tests
• Raised creatine kinase (CK) levels in blood tests
• Increased eosinophil count in blood tests
• Low red blood cell count (anaemia)
• Raised vitamin E levels in blood tests
• Reduced LDL cholesterol levels in blood tests

Other General Warnings

• You develop severe or persistent abdominal pain, as this is one of the most common side effects and may require a dose reduction, a treatment break, or stopping the medicine
• You develop frequent, watery, or persistent diarrhoea, as this can lead to dehydration and electrolyte imbalance and may require the dose to be reduced or stopped
• You have serious liver disease, as Bixiva tablet works through the bile acid system and may not achieve its expected effect in patients with liver problems or reduced bile acid secretion
• You develop a skin rash or hives (urticaria) at any time during treatment, as this may indicate a hypersensitivity (allergic) reaction and the medicine may need to be permanently stopped
• You are taking digoxin (for heart conditions) or dabigatran (a blood thinner), as Bixiva tablet can raise their blood levels and increase the risk of their side effects; closer monitoring will be needed
• You are taking ursodeoxycholic acid, chenodeoxycholic acid, cholestyramine, or aluminium-containing antacids, as these medicines can reduce the effectiveness of Bixiva tablet when taken at similar times
• You are 65 years or older, as dose reductions may be needed and physiological functions generally reduce with age
• You have known kidney or liver problems, as these may affect how safely and effectively this medicine works
• You notice unusual blood test results including raised liver enzymes or creatine kinase levels during treatment, as regular monitoring may be needed

• Take Bixiva tablet exactly as your doctor tells you
• Swallow the tablets whole with water before eating; taking this medicine before a meal is important for how well it works
• Your doctor will review your treatment regularly to check whether you still need to continue Bixiva tablet, as aimless long-term use should be avoided

• Store at room temperature, not exceeding 30°C.
• Do not freeze.
• Keep out of reach of children and pets.

• Always remove the tablets from the blister strip before swallowing; never swallow the tablets while still inside the blister packaging, as the sharp plastic edges can cause serious injury to the food pipe
• Take Bixiva tablet before a meal, not with or after food; food significantly reduces how much of this medicine your body absorbs
• Tell your doctor right away if you develop severe or persistent diarrhoea or abdominal pain, as your dose may need to be reduced or the medicine temporarily stopped
• Your doctor will review your treatment regularly; this medicine should only be continued as long as it is needed and is working
• Keep a simple diary of your bowel movements to help your doctor assess how well the medicine is working and whether a dose adjustment is needed
• Elderly patients may need a lower dose; always follow your doctor's specific instructions if you are older
• Inform all your doctors and pharmacists that you are taking Bixiva tablet, as it can affect the blood levels of certain medicines, including digoxin and dabigatran

Overdose

• There is no specific data on what happens with an overdose of Bixiva tablet. Do not take more than the maximum dose of 15 mg per day as prescribed by your doctor. If you think you have taken too many tablets, contact your doctor or go to the nearest emergency department right away.
• Watch closely for worsening of side effects such as severe diarrhoea and abdominal pain if too much has been taken, and seek medical help promptly.

Missed a Dose

• If you miss your dose of Bixiva tablet before a meal, skip the missed dose if you have already eaten that meal without taking it. Take your next dose before your meal the following day at the usual time.
• Do not take double doses to make up for a missed one. If you are unsure what to do, contact your doctor or pharmacist for advice.

Interactions with other medicines

• Bile acid medicines such as ursodeoxycholic acid and chenodeoxycholic acid may become less effective when taken alongside Bixiva tablet, as this medicine blocks the same bile acid transporter these medicines rely on
• Antacids containing aluminium (such as sucralfate) and cholesterol-lowering resins such as cholestyramine and colestimide may reduce the effectiveness of Bixiva tablet by binding bile acids in the gut; avoid taking these at the same time as your Bixiva tablet dose
• Digoxin (a heart medicine) and dabigatran (a blood thinner) may reach higher levels in the blood when taken alongside Bixiva tablet, which could strengthen their effects; your doctor will monitor you closely if you take these medicines
• Midazolam (a sedative) blood levels may be reduced by Bixiva tablet, which could make it less effective; inform your doctor if you take midazolam
• Always tell your doctor about all medicines, supplements, vitamins, and herbal products you take before starting treatment

Interactions with food items

• Bixiva tablet must be taken before a meal; taking it with or after food significantly reduces the amount of medicine absorbed and may make it less effective
• There are no specific foods known to directly interact with this medicine, but taking it consistently before the same meal each day helps ensure reliable absorption
• Drink enough water and fluids throughout the day to support bowel motility and to prevent dehydration if diarrhoea occurs
• Avoid alcohol during treatment, as it can worsen diarrhoea and abdominal discomfort, which are already common side effects