Arbaz 60 Mg Injection 1.5 Ml

• If you have a known hypersensitivity or severe allergic reaction to cabazitaxel, other taxanes, or polysorbate 80.
• If your baseline white blood cell count (neutrophil count) is too low
• If you have severe liver impairment (total bilirubin more than 3 times the upper limit of normal).

• Low white blood cell count (neutropenia), significantly increasing the risk of severe infections.
• Low red blood cell count (anaemia), causing fatigue, weakness, and shortness of breath.
• Low platelet count (thrombocytopenia), leading to easy bruising or bleeding.
• Diarrhoea, nausea, vomiting, and loss of appetite.
• Fatigue, asthenia (weakness), and fever.
• Blood in the urine (haematuria).
• Musculoskeletal pain, including back pain.
• Taste changes (dysgeusia) and peripheral swelling (oedema).

• Hair loss (alopecia), which is a common side effect of cabazitaxel.
• Urinary tract infections.
• Constipation, abdominal pain, and mouth sores (stomatitis).
• Peripheral neuropathy (numbness, tingling, or pain in the hands and feet).
• Shortness of breath, cough, and joint pain.
• Dizziness and headache.
• Low lymphocyte count and weight loss.

• Severe, life-threatening neutropenic fever and serious infections, such as sepsis or pneumonia.
• Severe, persistent diarrhoea leading to dehydration and kidney failure.
• Serious gastrointestinal problems, including bleeding, perforation, bowel obstruction, and neutropenic enterocolitis (bowel inflammation). The risk is higher with neutropenia, older age, steroid use, concurrent NSAIDs or blood thinners, or prior pelvic radiotherapy.
• Severe hypersensitivity reactions, including rash, flushing, low blood pressure, or breathing difficulties.
• Interstitial lung disease or severe respiratory complications.
• Kidney failure or severe urinary tract disorders.
• Severe bladder inflammation (haemorrhagic cystitis) or radiation-recall cystitis, particularly in patients previously treated with pelvic radiation. This can occur even late in treatment and may require hospitalisation.

Other General Warnings

• You are 65 years of age or older, which may make you more likely to experience certain side effects and require closer monitoring.
• You have pre-existing liver impairment, as dosage adjustment is required. A lower dose is used for mild or moderate liver impairment, and the medicine is contraindicated in severe liver impairment.
• You have pre-existing kidney impairment. No dose adjustment is generally needed unless kidney function is very severely reduced, in which case your doctor will monitor you closely.
• You experience fever, chills, or any signs of infection during treatment, as prompt medical intervention is required.
• You notice severe, persistent diarrhoea, abdominal pain, signs of dehydration, or blood in your stool.
• You develop sudden allergic symptoms during or shortly after the infusion, such as rash, wheezing, or dizziness.
• You have previously received radiation to the pelvic area, as you may be at higher risk of bladder-related side effects.
• You have any underlying lung disease, as you may be at higher risk of lung-related side effects.

• Arbaz injection is always prepared and administered by a trained healthcare professional as an intravenous infusion in a hospital or clinic.
• Do not attempt to self-administer or prepare this medication at home.
• Before each infusion, you will be given premedication directly into a vein, such as an antihistamine, a corticosteroid, and an H2 antagonist, along with anti-sickness medicine as needed, to reduce the risk of allergic reactions and nausea.
• Keep all scheduled appointments for your treatment cycles and blood tests.

• Hospital pharmacies and clinical staff handle storage of Arbaz injection vials. Store the vials according to the manufacturer's specified storage conditions.
• Keep out of the reach of children and pets in a secure medical environment.
• Proper disposal of vials, dilution bags, and infusion equipment is handled by clinical staff in accordance with hospital biomedical waste protocols, as this is a hazardous anticancer medicine.

• Keep all scheduled blood test appointments so your doctor can check your white blood cell counts before every treatment cycle.
• Report any fever, chills, sore throat, or signs of infection to your medical team immediately, as neutropenic fever is a medical emergency.
• Stay well-hydrated and inform your doctor right away if you experience severe diarrhoea or vomiting.
• Watch for unusual bruising, tiny red spots on the skin, or bleeding from the gums or nose.
• Report any blood in your urine, burning during urination, or urinary urgency to your doctor promptly, especially if you have previously had pelvic radiation.
• Inform all your healthcare providers that you are taking this medication before undergoing any other medical procedures or dental work.
• If you are 65 years of age or older, you may be more likely to experience certain side effects and should be monitored particularly closely.

Missed a Dose

• If you miss a scheduled infusion appointment, contact your hospital or oncology clinic immediately to reschedule.
• Do not attempt to make up for a missed session on your own, as your doctor will adjust your treatment schedule safely based on your blood counts and recovery status.

Overdose

• There is no known antidote for Arbaz injection overdose. Overdose has been reported to result from improper preparation or dilution of the medicine.
• If an overdose is suspected, emergency medical intervention must be initiated immediately in a hospital setting. Symptoms can include profound bone marrow suppression, severe neutropenia, high fever, and severe gastrointestinal toxicity, and can be fatal.
• Management involves supportive hospital care, including appropriate infection management and, when indicated, granulocyte colony-stimulating factor (G-CSF), and intensive clinical monitoring.

Interactions with other medicines

• Avoid strong CYP3A inhibitors, such as ketoconazole, itraconazole, clarithromycin, atazanavir, ritonavir, or telithromycin, as they can increase cabazitaxel blood levels and the risk of severe side effects. If a strong CYP3A inhibitor cannot be avoided, your doctor may reduce the Arbaz injection dose by about 25%.
• Avoid strong CYP3A inducers, such as rifampicin, carbamazepine, or St. John's wort, as they can decrease cabazitaxel blood levels and effectiveness.
• Inform your doctor about all prescription medicines, over-the-counter medicines, and herbal supplements you are taking, especially blood thinners, NSAIDs, or other chemotherapy medicines.

Interactions with food items