Afatin 40Mg Bottle Of 28 Tablets
28 Tablet(s) in BottleMRP ₹6300.00
₹5220.00
17% OFF
Made by
BDR PHARMACEUTICALS INTERNATIONALS PVT LTD
Dosage
TABLET
Expiry
Product Summary
| Uses | Advanced/metastatic non-small cell lung cancer |
| Therapy | Anti-neoplastic |
| Side effects | Diarrhea, mouth sores, dry sin, nausea, decreased appetite |
| Salt Content | Afatinib(40.0 Mg) |
Assurance
available
Regulated
Medical Description
Afatin tablet contains afatinib as its active ingredient. It belongs to a class of drugs called kinase inhibitors, specifically a second-generation irreversible inhibitor of the ErbB family. Certain cancer cells rely on abnormal epidermal growth factor receptor (EGFR) proteins to send continuous growth and survival signals, allowing the tumour to grow and spread. Afatinib irreversibly binds to and blocks the entire ErbB receptor family, including EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4), shutting down these signaling pathways to slow or stop cancer cell growth. It comes as a film-coated tablet taken by mouth.
This medicine treats adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have specific genetic mutations in the EGFR gene (such as exon 19 deletions or exon 21 L858R substitution mutations), or patients with metastatic squamous NSCLC that has progressed after platinum-based chemotherapy. Before starting treatment for non-small cell lung cancer, a validated test must confirm an EGFR mutation.
Afatin tablet is an oral medicine taken once daily at home on an empty stomach. Treatment is started and supervised by a specialist doctor, and it continues as long as the cancer keeps responding and side effects remain manageable
Uses
Contraindications
- If you are allergic to afatinib or any other ingredient present in this medicine.
- Pregnancy and breastfeeding require special precautions and should be discussed with your doctor.
Side effects
- Diarrhoea ( sometimes severe)
- Skin rash, acne-like bumps, and itchy skin
- Mouth sores and ulcers
- Inflammation of the skin around the nails (paronychia)
- Decreased appetite and weight loss
- Nausea and vomiting
- Dry skin
- Fatigue and weakness
- Changes in taste (dysgeusia)
- Nosebleeds
- Dry eyes, watery eyes, or eye irritation (conjunctivitis)
- Indigestion or heartburn
- Lip inflammation or chapping (cheilitis)
- Elevated liver enzymes in blood tests
- Fever (pyrexia)
- Severe diarrhoea: causes excessive fluid loss (dehydration) and severe kidney complications.
- Serious lung inflammation (interstitial lung disease/pneumonitis): It can be severe, life-threatening, or fatal; symptoms include new or worsening shortness of breath, cough, fever, or chest pain.
- Severe skin reactions: Severe blistering, peeling skin, or painful spreading rash.
- Serious liver problems: Symptoms include yellowing of the skin or eyes (jaundice), dark urine, and upper right abdominal pain.
- Stomach or intestinal perforation: Symptoms include sudden, severe stomach pain or black/tarry stools.
- Serious eye problems: Report eye pain, severe redness, blurred vision, or other new vision problems promptly.
Directions for Use
- Take Afatin tablet exactly as your doctor prescribed.
- Take this medicine on an empty stomach, at least 1 hour before eating or 2 hours after a meal. Always consult your doctor before use.
- Swallow the tablet whole with a full glass of water. Do not chew, crush, or break it.
- Try to take your dose at the same time every day to maintain a steady level of medicine in your body.
Storage and disposal
- Store below 30°C in the original packaging to protect it from direct sunlight and moisture.
- Keep out of the reach of children and pets.
- Discard the medicine if expired.
Quick Tips
- Always take Afatin tablet on an empty stomach, either 1 hour before a meal or 2 hours after a meal.
- Swallow the tablet whole with water. Never crush, break, or chew it.
- Stay well hydrated and let your doctor know immediately if you develop diarrhoea, as early treatment with anti-diarrhoeal medication is often needed.
- Protect your skin from direct sunlight by using sunscreen and wearing protective clothing, as this medicine can make your skin more sensitive to sun exposure.
- Follow all your scheduled appointments so your doctor can check your response to treatment.
Dosage
Overdose
Missed a Dose
How does this medicine work?
Interactions
Interactions with other medicines
Interactions with food items
Frequently Asked Questions (FAQs)
References:
- Moosavi L, Preuss CV, Polineni R, Tadi P, Aeddula NR. Afatinib [Internet]. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024
- Central Drugs Standard Control Organisation (CDSCO), Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India. List of New Drugs Approved by CDSCO: Afatinib Tablets (20mg, 30mg, 40mg, 50mg) [Internet]. New Delhi: CDSCO; 2014 Dec 30
- U.S. Food and Drug Administration. FDA approves first generics of Gilotrif (afatinib) tablets [Internet]. Silver Spring (MD): U.S. Food and Drug Administration
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Manufacturer Details
Brand:AFATIN
Manufacturer Name:BDR PHARMACEUTICALS INTERNATIONALS PVT LTD
Address:BDR Pharmaceuticals intl pvt ltd - R.s.No 578, near effluent channel road, vill.luna, tal.padra, dist.vadodara 391440, gujarat
Country of Origin:India
Vendor Details
Fulfillment Information: Afatin 40 MG Tablet (28) will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.
In Case of Any Issues Contact Us
Email Id:care@pharmeasy.in
Phone Number:7666100300
Address:D-37/1, Opp. Sandoz, TTC Industrial Area, MIDC Industrial Area, Turbhe, Navi Mumbai, Maharashtra 400703
Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
