Vitamin B6 / Pyridoxine+Isoniazid
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Molecule Summary
| Uses | Tuberculosis (TB) |
| Therapy | Anti-Tubercular |
| Side Effects | Rash, peripheral neuropathy, fever, increased liver enzymes, jaundice, hepatitis |
Medicines
available
19k pincodes
Molecule Description
Vitamin B6 / Pyridoxine+Isoniazid is used in tuberculosis (TB) therapy. It is a combination of two medicines, Isoniazid and Pyridoxine. It stops the TB causing bacteria from multiplying.
Uses
- Treatment of Tuberculosis (TB)
Contraindications
When should one not use Vitamin B6 / Pyridoxine+Isoniazid
- Peripheral Neuropathy (weakness, numbness or pain in the hands and feet due to damage to nerves)
- Acute liver disease
- Jaundice
- Allergy to Vitamin B6 / Pyridoxine+Isoniazid or any of its components
Side effects
Common side effects of this drug are:
- Rash
- Peripheral neuropathy (tingling and numbness of hands and feet)
- Fever
- Jaundice
- Hepatitis
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You should take Vitamin B6 / Pyridoxine+Isoniazid as your doctor prescribes.
- You should not miss any doses and complete the whole course of the medication.
- Your doctor may check your liver function, eyesight, and thyroid function during therapy with this medicine.
- You have diabetes or kidney disease; tell your doctor before taking this medicine.
Mode of Action
How Does It Work?
Vitamin B6 / Pyridoxine+Isoniazid is a combination of two medicines: Isoniazid and Pyridoxine. Isoniazid is an antibiotic that prevents tuberculosis bacilli from making their protective layer. It eliminates the disease by killing the bacilli. Isoniazid may lead to nerve damage. Hence, Vitamin B6 or Pyridoxine helps to prevent it.
Interactions
Interactions with other medicines
- Sedative medicines (used for sedation)
- Anti-anxiety medicines
- Levodopa (anti-Parkinson's medicine)
- Caffeine
- Phenobarbital (Anti-epileptic)
- Conjugated Estrogens (Used in menopausal syndrome)
- Phenytoin (Anti-epileptic)
Interactions with food items
- It may be advised to not take Vitamin B6 / Pyridoxine+Isoniazid with foods containing tyramine (like tofu, kimchi, pickled cucumbers, dried sausages or smoked fish), cheese, smoked salmon, poultry, and alcohol. Also, avoid grapefruit juice since there may be adverse reactions.
Dosage
Overdose
If you believe you have taken an extra dose, contact the emergency room immediately. Seek emergency medical help.
Missed a Dose
Take Vitamin B6 / Pyridoxine+Isoniazid as soon as you remember if you miss a dose. However, omit the missing amount and return to your usual schedule when your next dosage is approaching. Do not take an extra dose.
Frequently Asked Questions (FAQs)
Articles
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References:
- Isoniazid: Medlineplus drug information [Internet]. MedlinePlus. U.S. National Library of Medicine; [cited 2026 Jun 3]. Available from:
- Denholm JT, McBryde ES, Eisen DP, Penington JS, Chen C, Street AC. Adverse effects of isoniazid preventative therapy for latent tuberculosis infection: a prospective cohort study. Drug Healthc Patient Saf [Internet]. 2014 [cited 2026 Jun 3];6:145–9. Available from:
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