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Trimethoprim

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Molecule Description

Trimethoprim is an antibiotic that is used in the treatment of bacterial infections. It belongs to the Sulfonamide group of medicines.

Uses

  • Infections caused by Trimethoprim sensitive bacteria
  • Urinary tract infections (recurrent urinary tract infections)
  • Respiratory tract infections

Contraindications

When should one not use Trimethoprim

  • Do not take if you are allergic to Trimethoprim or any ingredient of this medicine
  • Do not take this medicine in pregnancy
  • Do not take this medicine if you suffer from any blood disorders such as anaemia
  • Do not take this medicine for premature babies or infants under 4 months of age

Side effects

Common side effects of this drug are:

  • Hyperkalaemia (high levels of potassium in the blood)
  • Vomiting
  • Diarrhea
  • Nausea
  • Stomach discomfort
  • Skin rash
  • Oral ulcers
  • High potassium level – muscle weakness, slow heart rate, etc.
  • Headache

Precautions and Warnings

Pregnancy

Pregnancy

You should not take this medicine during pregnancy. It is harmful to the unborn baby.

Breast Feeding

Breast Feeding

It is probably unsafe to take this medicine if you are breastfeeding. This medicine passes into breast milk. However, it can be taken for a short duration if prescribed by the doctor.

Driving

Driving

No specific interaction has been reported yet.

Alcohol

Alcohol

It is unsafe to consume alcohol with this medicine. It may lead to unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea and vomiting.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have kidney problems, diabetes, folic acid deficiency (may cause anaemia), any disorder that causes skin sensitivity to light, pain attacks and muscle weakness
  • You are taking Repaglinide (medicine for treating diabetes), difficulty while urinating or a weak stream of urine, pain or swelling in your stomach area
  • You are taking any medicines including prescription medicines, non prescription medicines and herbal products

Mode of Action

How Does It Work?

It kills and controls the growth of the bacteria by interfering with its Folic Acid metabolism.

Interactions

Interactions with other medicines

  • Repaglinide
  • Rifampicin
  • Digoxin
  • Phenytoin
  • Spironolactone
  • Bone marrow depressants
  • Pyrimethamine and Dapsone
  • Potassium supplements
  • Medicines used for the treatment of high blood pressure
  • Methotrexate
  • Procainamide
  • Diuretics

Dosage

Overdose

Seek emergency medical care if you happen to take an overdose of this medicine. Overdose symptoms include difficulty in breathing and uneasiness.

Missed a Dose

Take the next dose as soon as you remember; if the time for your next dose is close then skip it. Do not take a double dose if you have missed the dose.

Frequently Asked Questions (FAQs)

Tell your doctor if you have:Heart problemsKidney problemsBreathing problem like asthmaDiabetes – regular monitoring of blood glucose levelHave abnormally low levels of potassium (hypokalaemia), calcium (hypocalcaemia) or magnesium (hypomagnesaemia) in your bloodHave difficulties in passing urine or a weak stream of urineLiver problemsIn case you started to have pain or swelling in your stomach area

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